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Small Animals, Big Achievements
Small-animal imaging is integral to a variety of preclinical imaging applications – with researchers monitoring changes in organs and tissue, for example, in response to physiological or environmental changes. A host of imaging modalities have been introduced over the years to address the myriad questions that inevitably arise. When imaging animals, investigators often want to see how an organ is working inside the body. They want to know about the consumption of nutrients, for in...
BioPhotonics, March 2011
Biomedical Applications Revealed for Terahertz Spectroscopy
Beyond the infrared, but just before you arrive at the microwaves, awaits an emergent area of opportunity for biomedical research: the terahertz region. Spanning from 0.3 to 3 THz (equivalent to 100 to 1000 µm), this wavelength range allows...
BioPhotonics, February 2011
Femtosecond Lasers Enable Bladeless Eye Surgery
In the past few years, femtosecond lasers have become the “bladeless scalpel” of choice for ophthalmic surgeons. By nature, femtosecond lasers produce extremely brief, high-energy light pulses that can sear targeted tissue so quickly and...
BioPhotonics, February 2011
Not Your Father’s Microscope
Researchers have devoted increasing effort to developing microscopes that can be used in the field for global health applications. Some have started with the conventional microscope design, condensed it and replaced many of the existing components...
BioPhotonics, February 2011
Cooperation + Openness = Innovation
Producing a winning idea is not an instantaneous event but an ongoing process. Even if you are struck with an inspiration for a novel technology, for a better way to accomplish an everyday task, or for a new application or market for a biophotonics...
BioPhotonics, January 2011
Polymer Optics for Thermally Stable Imaging
There is currently a soaring demand for high-performance optics and optical systems applications in the fields of optometry, biomedicine, microscopy, and a number of related scientific and industrial fields. Due to advances in the microelectronics...
BioPhotonics, January 2011
Q & A: Trends in Life Sciences Spectroscopy
Optical spectroscopy can be used to monitor nearly everything with which we come into contact – food, water, air, chemicals – as well as the state of our health and the health of our world. It can be used in research labs and in...
BioPhotonics, January 2011
Superresolution: Reality or a “STORM” in a Teacup?
Imagine “zooming into the cell”1 and seeing not only the most delicate structures but critical processes in action. Well, superresolution (SR) imaging allows biologists and chemists to do just that. In 2008, Nature voted this new field...
BioPhotonics, January 2011
Ultrafast Lasers for Microscopy: Flexibility Plus State-of-the-Art Performance
Nonlinear microscopic imaging techniques are playing key roles across many areas of life sciences research because they can perform high-resolution, three-dimensional spatial imaging of specific chemical targets (labeled and unlabeled) in real time...
BioPhotonics, January 2011
Dutch Photonics Strives for Smaller, Faster and Cheaper
Located in North-West Europe and bordering the North Sea, Belgium and Germany, the Netherlands is well positioned as a key trading center. It has excellent transport links, including Schiphol Airport in Amsterdam, recognized as one of the major hubs...
Photonics.com, December 2010
A Cut Above: Robotics in Surgery
What began as a prototype system for performing battlefield surgery under contract to the US Army now offers thousands of patients shorter hospital stays, less scarring and a faster return to normal life after major surgery. The da Vinci...
BioPhotonics, November 2010
Active Illumination Microscopy for Live-Cell Imaging
Photobleaching and phototoxicity are unavoidable in fluorescence microscopy. The phenomenon of photobleaching occurs when, as a result of photo-induced modifications to the molecular structure, a fluorophore permanently loses the ability to...
BioPhotonics, November 2010
Cell Cultures in 3-D
Biologists have employed cell cultures since the middle of the past century, when they proved integral to the development of viral vaccines. For decades, cells were studied in essentially two-dimensional environments. The need for three-dimensional...
BioPhotonics, November 2010
For Medical Instruments, Going Small Pays Off Big
Size does indeed matter: For medical instruments, smaller often is better. The benefits can include greater capabilities, lower cost and better outcomes. In pulling off this trifecta, imaging plays an important role, as illustrated by three cases....
BioPhotonics, November 2010
Sound and Light, Signifying Improved Imaging
Pure light is good for many bioimaging studies, but it has insurmountable limitations when it comes to scanning beneath the surface of the skin. Light in the near-IR range of about 2 to 3 µm can penetrate tissue up to only 0.1 to 1 mm, far too...
BioPhotonics, November 2010
The French Connection: Optics in France and the US
It wasn’t so long ago, at the centuries-old Château Smith-Haut-Lafitte in the Pessac-Léognan appellation south of Bordeaux, that workers had to stand at long sorting tables manually removing pieces of leaves, raisins and other...
Photonics.com, October 2010
Body Vision: IR Applications and Lens Selection in Biomedical Settings
Although IR optics have long been used for military, surveillance and industrial applications, it is only recently that their full potential is being explored in biomedical settings. Common applications are to study veins in vivo, to image certain...
BioPhotonics, October 2010
Characterization of Intraocular Lenses: Different Measurement Methods
Intraocular lenses (IOLs) are artificial implants used to replace the human eye crystalline lenses in patients with cataracts. The standard IOL is designed to match the patient’s eye to provide good images of objects at infinity. The tendency...
BioPhotonics, October 2010
Combining Second-Harmonic Generation with Multiphoton Imaging
Second-harmonic generation (SHG) is a method of imaging structures in tissue using a pulsed near-infrared laser. The technique can be combined with various methods of fluorescence imaging to deduce molecular organization and other key aspects of...
BioPhotonics, October 2010
Next-Generation IR Microscopy: The Devil Is in the Detail
One of the most important attributes of infrared spectroscopy is its ability to handle physically small samples or small features on samples. Important applications include forensic analysis of a crime scene, where infinitesimal evidentiary samples...
BioPhotonics, October 2010
Optogenetics: A Conversation with Ed Boyden
In a few short years, optogenetics has gone from a glimmer in the eye in a handful of researchers to a viable technique used worldwide to study information processing in the brain. We recently caught up with one of the originators of the technique...
BioPhotonics, October 2010
Telehealth: Seeing, and Treating, Patients at a Distance
Rhonda Johnston, a nurse practitioner, has a simple requirement when it comes to the technology that allows her to serve patients scattered across southern Colorado: “Our goal is to make sure the telehealth patient encounter is no different...
BioPhotonics, October 2010
Cost-Effective, High-Performance Confocal Microscopy
Since the first commercial confocal laser scanning microscope (CLSM) was introduced more than 20 years ago, it has become an essential tool for life sciences research, contributing to many discoveries about cell and tissue structure and function....
BioPhotonics, September 2010
Personalized Medicine: No Longer Ahead of Its Time?
Personalized medicine – which takes advantage of molecular imaging, among other technologies, to determine the best course of treatment for individual patients – is an idea whose time has come. Here, we look at some of the obstacles...
BioPhotonics, September 2010
Pushing the boundaries in live-cell light microscopy
Ever since Dutch scientist Antonie van Leeuwenhoek first described the cellular world in the 1660s, the disciplines of biology and physics have been pushing each other to design better tools and methods for exploring the microscopic living world....
BioPhotonics, September 2010
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