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Features
Ultrafast Lasers for Microscopy: Flexibility Plus State-of-the-Art Performance
Nonlinear microscopic imaging techniques are playing key roles across many areas of life sciences research because they can perform high-resolution, three-dimensional spatial imaging of specific chemical targets (labeled and unlabeled) in real time and in living tissue. In turn, laser manufacturers have simplified these techniques and broadened access to them by developing “one box” ultrafast lasers that provide turnkey operation for microscopy. At first, the emphasis of thes...
BioPhotonics, January 2011
Dutch Photonics Strives for Smaller, Faster and Cheaper
Located in North-West Europe and bordering the North Sea, Belgium and Germany, the Netherlands is well positioned as a key trading center. It has excellent transport links, including Schiphol Airport in Amsterdam, recognized as one of the major hubs...
Photonics.com, December 2010
A Cut Above: Robotics in Surgery
What began as a prototype system for performing battlefield surgery under contract to the US Army now offers thousands of patients shorter hospital stays, less scarring and a faster return to normal life after major surgery. The da Vinci...
BioPhotonics, November 2010
Active Illumination Microscopy for Live-Cell Imaging
Photobleaching and phototoxicity are unavoidable in fluorescence microscopy. The phenomenon of photobleaching occurs when, as a result of photo-induced modifications to the molecular structure, a fluorophore permanently loses the ability to...
BioPhotonics, November 2010
Cell Cultures in 3-D
Biologists have employed cell cultures since the middle of the past century, when they proved integral to the development of viral vaccines. For decades, cells were studied in essentially two-dimensional environments. The need for three-dimensional...
BioPhotonics, November 2010
For Medical Instruments, Going Small Pays Off Big
Size does indeed matter: For medical instruments, smaller often is better. The benefits can include greater capabilities, lower cost and better outcomes. In pulling off this trifecta, imaging plays an important role, as illustrated by three cases....
BioPhotonics, November 2010
Sound and Light, Signifying Improved Imaging
Pure light is good for many bioimaging studies, but it has insurmountable limitations when it comes to scanning beneath the surface of the skin. Light in the near-IR range of about 2 to 3 µm can penetrate tissue up to only 0.1 to 1 mm, far too...
BioPhotonics, November 2010
The French Connection: Optics in France and the US
It wasn’t so long ago, at the centuries-old Château Smith-Haut-Lafitte in the Pessac-Léognan appellation south of Bordeaux, that workers had to stand at long sorting tables manually removing pieces of leaves, raisins and other...
Photonics.com, October 2010
Body Vision: IR Applications and Lens Selection in Biomedical Settings
Although IR optics have long been used for military, surveillance and industrial applications, it is only recently that their full potential is being explored in biomedical settings. Common applications are to study veins in vivo, to image certain...
BioPhotonics, October 2010
Characterization of Intraocular Lenses: Different Measurement Methods
Intraocular lenses (IOLs) are artificial implants used to replace the human eye crystalline lenses in patients with cataracts. The standard IOL is designed to match the patient’s eye to provide good images of objects at infinity. The tendency...
BioPhotonics, October 2010
Combining Second-Harmonic Generation with Multiphoton Imaging
Second-harmonic generation (SHG) is a method of imaging structures in tissue using a pulsed near-infrared laser. The technique can be combined with various methods of fluorescence imaging to deduce molecular organization and other key aspects of...
BioPhotonics, October 2010
Next-Generation IR Microscopy: The Devil Is in the Detail
One of the most important attributes of infrared spectroscopy is its ability to handle physically small samples or small features on samples. Important applications include forensic analysis of a crime scene, where infinitesimal evidentiary samples...
BioPhotonics, October 2010
Optogenetics: A Conversation with Ed Boyden
In a few short years, optogenetics has gone from a glimmer in the eye in a handful of researchers to a viable technique used worldwide to study information processing in the brain. We recently caught up with one of the originators of the technique...
BioPhotonics, October 2010
Telehealth: Seeing, and Treating, Patients at a Distance
Rhonda Johnston, a nurse practitioner, has a simple requirement when it comes to the technology that allows her to serve patients scattered across southern Colorado: “Our goal is to make sure the telehealth patient encounter is no different...
BioPhotonics, October 2010
Cost-Effective, High-Performance Confocal Microscopy
Since the first commercial confocal laser scanning microscope (CLSM) was introduced more than 20 years ago, it has become an essential tool for life sciences research, contributing to many discoveries about cell and tissue structure and function....
BioPhotonics, September 2010
Personalized Medicine: No Longer Ahead of Its Time?
Personalized medicine – which takes advantage of molecular imaging, among other technologies, to determine the best course of treatment for individual patients – is an idea whose time has come. Here, we look at some of the obstacles...
BioPhotonics, September 2010
Pushing the boundaries in live-cell light microscopy
Ever since Dutch scientist Antonie van Leeuwenhoek first described the cellular world in the 1660s, the disciplines of biology and physics have been pushing each other to design better tools and methods for exploring the microscopic living world....
BioPhotonics, September 2010
Standardized Units for Reproducible Imaging Experiments
Discerning why experimental results sometimes differ is problematic for researchers because current scientific cameras report data in nonstandardized ways, prohibiting direct and quantitative comparisons between experiments. “People in my lab...
BioPhotonics, September 2010
Tracking disease for science and the law
It was a case of what, and then possibly who, dunit. In early 2009, the Atlanta-based Centers for Disease Control and Prevention (CDC) announced that it was tracking a salmonella outbreak that had sickened hundreds and killed a handful. Ultimately...
BioPhotonics, September 2010
Consumers Dominate MEMS Market
The microelectromechanical systems (MEMS) market is expected to surpass a staggering $11 billion by 2012, according to Yole Développement, a French market research and strategy consulting company specializing in the MEMS, compound...
Photonics.com, August 2010
Bioapplications of Combined Optical and AFM Imaging Techniques
The atomic force microscope (AFM) has seen exciting and promising growth in its combination with optical microscopy. Although new optical techniques developed in the past few years have begun to push traditional limits, the lateral and axial...
BioPhotonics, July 2010
CMOS X-ray Imaging Enables More Efficient Stereotactic Biopsies
Technological advances in screening and diagnostic breast imaging have enabled practitioners to deliver high-quality, accurate health care services. Patients benefit from digital mammography because it is faster and uses less radiation than the...
BioPhotonics, July 2010
Is Vibration Control Really Necessary for Microscopy?
As a supplier of vibration control equipment, we at Newport are frequently asked if vibration control is really necessary for microscopy applications, and you might expect the answer to be “of course.” However, the correct response is...
BioPhotonics, July 2010
Nanosurgery operates at the cutting edge of medicine
Nanosurgery is forever hitting the headlines as research groups around the world explore the myriad applications for this precise technique. Couple this to the development of lasers with ever shorter pulse durations, and it’s little wonder...
BioPhotonics, July 2010
Bringing Superresolution to Fluorescence Microscopy
The latest incarnation of the modern fluorescence microscope has led to a paradigm shift. This wave is about breaking the diffraction limit first proposed in 1873 by Ernst Abbe. The implications of this development are profound. So-called...
BioPhotonics, May 2010
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