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FTIR Spectroscopy: A Comprehensive Biological Investigator
Almost every molecule in the universe interacts with IR radiation, which excites vibrations in the molecule, rendering Fourier transform IR (FTIR) spectroscopy a universal method to investigate biological systems. In contrast to many popular biophysical techniques — such as fluorescence spectroscopy, x-ray crystallography, or cryoelectron microscopy — samples in FTIR spectroscopy can be investigated label-free at room temperature in solution. Most structural methods yield only
BioPhotonics, Nov/Dec 2018
Quantitative Phase Imaging Advances Disease Detection
Following unprecedented success in controlling malaria worldwide, progress is now slowing. In fact, a 2017 report by the World Health Organization (WHO)1 clearly indicates that the world is no longer on track to reach the critical milestones for...
BioPhotonics, Nov/Dec 2018
Optimizing Probe Positioning for Life Science Research
Photonics technologies enable life scientists to probe samples in the increasingly sophisticated study of processes ranging from neuron signaling to heart muscle contraction, as well as cells and cellular development. As research continues at...
BioPhotonics, Nov/Dec 2018
Hand-Held AO Ophthalmoscopy Enables Cellular-Level Imaging
Advancements in adaptive optics (AO) are bringing researchers deeper into the human retina than ever before. Enabling the visualization of the living retina with cellular resolution, AO scanning laser ophthalmoscopy (AOSLO) has advanced the...
BioPhotonics, Nov/Dec 2018
Smartphone Spectroscopy Takes the Lab to the People
By 2020, the number of smartphone users in the world is expected to reach almost 2.9 billion — nearly doubling in six years from about 1.6 billion in 2014. Technology companies and researchers have been directly and indirectly imbuing...
BioPhotonics, October 2018
Neuroscience 2018 Encourages Collaboration
Developments in cell biology are uncovering new methods with which to study synaptic communication, social behavior circuits, and healthy and diseased brains. Advanced study and understanding of these and other aspects of the brain can aid better...
BioPhotonics, October 2018
Miniaturization, Increased Resolution Drive Microscopy’s Future
Miniature fluorescence microscopes and other system components, such as liquid lenses, are among emerging microscopy advancements that are bettering optical inspection in areas including the life sciences and machine vision. Now, such technology is...
BioPhotonics, October 2018
SHG Microscopy Brings Live Cells into 3D Focus
Second-harmonic generation (SHG) microscopy brings the imaging of select biomolecular assemblies into 3D focus. It highlights biomolecules that follow specific structural organization within biological tissues, and complements two-photon excited...
BioPhotonics, October 2018
Nanophotonic Biosensors Expand Live Cell Analysis
In an era of fast-emerging personalized therapies, accuracy and efficacy rely mainly on precise cell analysis and engineering. With advanced gene sequencing technologies, researchers have revealed the complex heterogeneity in the genomics,...
BioPhotonics, October 2018
Photothermal IR Spectroscopy Boosts Chemical Microscopy, Expands Applications
Current bioanalysis largely relies on tissue homogenization and separation, followed by various assays. Without spatial and temporal dynamics information, the way in which molecules execute their functions in a living system remains unknown....
BioPhotonics, September 2018
High-Precision Laser Therapy Transforms Dentistry
Since the late 19th century, the mechanical drill has served as the cornerstone of dentistry. However, as dentists’ responsibilities continue to expand — and after decades of academic research resulting in the advancement of...
BioPhotonics, September 2018
OCT Promising as Clear Point-of-Care Solution
Medical devices at the point of care allow clinicians to do what they do best: determine a patient’s exact condition and a course of treatment. These technologies work best when they fit seamlessly into the provider-patient workflow without a...
BioPhotonics, September 2018
Advanced Imaging Techniques Enhance Fluorescence Sensing
Detecting fluorescence light via imaging and fluorescence sensing can take researchers and clinicians into the body, allowing them to visualize samples and biological progression of areas such as cancer detection or cardiovascular function. The...
BioPhotonics, September 2018
Lensless Cameras May Offer Detailed Imaging of Neural Circuitry
Understanding brain function at the scale of individual neurons could open the door for advanced understanding of animal and human behavior and the mechanisms of neurological disorders such as Alzheimer’s. But the size scale of neurons and...
BioPhotonics, Jul/Aug 2018
Fluorescence Microscopy Unravels Morphogenesis, Function of Lymph System
The lymphatic system is an underinvestigated part of the vascular system. A team led by Friedemann Kiefer at the European Institute for Molecular Imaging (EIMI) at the University of Münster in Germany is aiming to change that in ongoing studies...
BioPhotonics, Jul/Aug 2018
Double-Helix Point Spread Function Delivers Precise Extended-Depth Microscopy
Light microscopy is a powerful method used in many scientific disciplines, including the life sciences, to visualize finer details in samples. The use of fluorescence enables specific targeting and labeling of biomolecules and other chemicals....
BioPhotonics, Jul/Aug 2018
Member Exclusive
Point-of-Care Optics Helps Halt the Spread of Infectious Diseases
Early diagnosis is the critical starting point to a better outcome for a patient. It allows effective treatment to start earlier, giving the patient the best possible prognosis. Prompt diagnosis also reduces the potential spread of infection,...
BioPhotonics, Jul/Aug 2018
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3D Printing Creates Patient-Specific Implants
Every patient is unique. Hence, nothing is more natural than providing each patient with a unique implant. Thanks to laser-based additive manufacturing, this is already possible. Patient-specific titanium implants manufactured by laser sintering,...
BioPhotonics, May/Jun 2018
The McCree Curve Demystified
Urban and periurban agriculture is rapidly becoming part of local economies. It is supported by increased consumer demand and preference for high-quality, locally produced foods. Socially, it is reacquainting people with food and the farm, and it is...
BioPhotonics, May/Jun 2018
Raman Hyperspectroscopy Shows Promise for Diagnosis of Alzheimer’s
Raman hyperspectroscopy combined with advanced statistics is uniquely suitable for characterizing microheterogeneous systems. Understanding the structure and biochemical composition of samples at the microscopic level is important for many practical...
BioPhotonics, May/Jun 2018
Nonconfocal 3D Microscopy Combines Real-Time Images with Depth of Focus
Stereo 3D microscopes produce real-time 3D images, but they are usually limited to low-magnification applications, such as dissection. Most compound light microscopes produce flat, 2D images because high-magnification microscope lenses have...
BioPhotonics, May/Jun 2018
Multiphoton Microscopy Sets the Standard for Live-Cell Imaging
Multiphoton imaging is widely used for live-cell imaging. Many of the applications are in neuroscience, where the overarching trends involve deeper imaging using longer wavelengths. These trends are the leading drivers behind the latest generation...
BioPhotonics, April 2018
Vying for Dominance: Swept-Source vs. Spectral-Domain OCT
Optical coherence tomography (OCT) is among the most widely used in vivo optical diagnostic techniques. This high-resolution 3D imaging modality, with market size approaching $1 billion, has established itself as an indispensable tool for...
BioPhotonics, April 2018
Remote Noninvasive Sensor Monitors Multiple Bioparameters
Photonic-based sensing is an evolving field that provides a large variety of possible biomedical applications for home care diagnosis. Various aspects of light and photons can grant us the ability to create smart sensors based on imaging tools for...
BioPhotonics, April 2018
Member Exclusive
SMS Reveals Hidden Behaviors
It was 28 years ago that the first optical experiments to detect a single molecule took place in the Moerner Laboratory at IBM Research, with relatively esoteric, low-temperature, high-resolution spectral measurements. Since then, room-temperature...
BioPhotonics, April 2018
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