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Innovations in the STORM Method Reveal Vital Clues to Disease Formation
Scientists and clinicians have long believed that visualizing structural changes in the nucleus of cancer cells would unlock vital clues about how the disease first forms. This information could provide the ability to track where and how cancer is progressing to plan its successful treatment. Traditional microscopy methods have fallen short in revealing these details because the microscope’s inherent resolution limit only allows the imaging of general structural changes, as opposed to resolving...
BioPhotonics, Nov/Dec 2022
The Evolution of Scientific Cameras Leads to the Advancement of Microscopy
Most people are familiar with standard qualitative cameras and bright high-contrast images, thanks to the prevalence of increasingly powerful smartphone and digital cameras in the marketplace. Scientific-grade cameras, however, are designed to be...
BioPhotonics, Nov/Dec 2022
A Multiphoton Microscope Enables Portable 3D Biological Imaging
For decades, optical microscopy has provided the mechanism with which to image cells and tissue for the purposes of cancer research, digital pathology, and the study of the brain. Samples are typically studied in frozen sections. Most of these...
BioPhotonics, Sep/Oct 2022
Optical Fiber Provides Real-Time Diagnostic Guidance
The biomedical community recognized the advantages of optical fibers long ago, accepting them even before their adoption for long-haul telecommunications. Early research on the light-guiding properties of fibers in the late 1920s was aimed at...
BioPhotonics, Sep/Oct 2022
Portable Reflectance Confocal Microscopy for Low-Resource Settings
Reflectance confocal microscopy (RCM) is an optical imaging technology that captures reflected light from tissue to visualize the tissue’s cellular morphologic details. The method does not require excision of the tissue or the use of fluorescent dye...
BioPhotonics, Nov/Dec 2022
Advanced Laser Scanning Enables High-Precision Vision Corrections
Scan heads with innovative controls are already used in many industrial laser-based applications that require the highest precision and throughput. Now the benefits of scanning with zero tracking error are being positioned for ophthalmic...
BioPhotonics, Sep/Oct 2022
Versatility in OCT System Design Opens the Door to New Clinical Applications
Optical coherence tomography (OCT), a noninvasive imaging technology, is a standard diagnostic tool used in the field of ophthalmology. With the advent of new compact form factors for the modality, as well as the assistance of artificial...
BioPhotonics, Sep/Oct 2022
Expanding the Range: Wearables Enable the Next Level of Mobile Health Data Monitoring
The next generation of wearable devices will no longer be created only for the fitness-conscious to monitor their daily steps or heart rate on a smartwatch. Increasingly sophisticated photonic components such as LED arrays and specialized lasers, as...
BioPhotonics, Jul/Aug 2022
Photoacoustic Imaging Uses LED Light to Guide Cancer Diagnosis and Therapy
Efficient medical imaging techniques such as photoacoustic imaging help to accurately detect diseases as early as possible, resulting in timely intervention and reducing the need for medication and surgery. Conventionally used medical imaging...
BioPhotonics, Jul/Aug 2022
Raman Spectroscopic Method Diagnoses Infection at the Point of Care
Millions of people worldwide die from infectious diseases each year, and the spread of these diseases poses a real threat to the survival of public health systems. How quickly health care institutions can be overburdened when an infection rapidly...
BioPhotonics, Jul/Aug 2022
Spectral Monitoring Reveals the Health of River and Lake Ecosystems
Rivers represent just a small fraction of the water on Earth’s surface, but they serve as vital natural resources for numerous cities and communities worldwide. River systems supply food and water, they can be a means of transport and...
BioPhotonics, Jul/Aug 2022
Fluorescence Imaging Deepens the View: From Single Cells to the Subcellular
The human body is made up of trillions of cells, and each one is as unique as the person it is part of. Each individual cell is arranged alongside its neighbors in a specific pattern that is essential to its systemic role within the tissue. In...
BioPhotonics, May/Jun 2022
Photonics Spectra Spectroscopy Conference to Showcase Advancements in Biomedicine
Join Photonics Media online April 12-13 for the Photonics Spectra Spectroscopy (PSS) Conference, a virtual event exploring new and evolving trends in spectroscopy. Biospectroscopy is one of four featured tracks in the program, which was curated in...
BioPhotonics, Mar/Apr 2022
Hyperspectral Imaging Characterizes Healthy and Diseased Tissues During Surgery
Upgrades in medical imaging technology have made possible the accurate diagnosis and successful treatment of ailments ranging from broken bones to cancer. Techniques such as endoscopy keep evolving to image at greater depth and with stronger...
BioPhotonics, May/Jun 2022
QCL-IR Microscopy: Delivering Molecular Information at Unprecedented Speed
As microspectroscopic imaging applications have expanded, analytical scientists have demanded advancements from existing imaging technology. Such advancements are particularly critical for biomedical applications, such as tissue analysis in cancer...
BioPhotonics, May/Jun 2022
AI Bridges the Gap Between Medical Imaging and Analysis
Improvements in the automation of functional mechanical, electrical, and optical components — along with increasing computing power for image analysis — have enabled the development of high-throughput microscopes, such as the whole slide scanners...
BioPhotonics, May/Jun 2022
LEDs and Optical Filters Expand Live-Cell Imaging Capability
The light source of a wide-field fluorescence microscope is often overlooked by scientists who perform live-cell imaging experiments. However, innovations such as transistor-transistor logic (TTL) triggering, which enhances on/off speed, and inline...
BioPhotonics, Mar/Apr 2022
The Biophotonics Congress Will Explore Image Analysis and Wearable Monitoring
The upcoming Biophotonics Congress: Biomedical Optics will feature optical technologies ranging from spectroscopy and endoscopy for the diagnosis of disease to computational pathology and wearable sensors that monitor vital health statistics. The...
BioPhotonics, Mar/Apr 2022
Hyperspectral Imaging Tracks Blood Oxygen Levels, Aiding in Disease Treatment
The measurement of blood oxygen levels, or oxygen saturation (SpO2), is a critical medical diagnostic parameter. Levels below 95% are considered abnormal and called hypoxemia, or blood oxygen deficiency. This condition is associated with patients...
BioPhotonics, Mar/Apr 2022
The Pandemic Is Driving Innovative Microfluidic Disease Detection
As medicine and the monitoring of health have advanced into the modern era, researchers and clinicians have sought to capture an ever-increasing number of the biomarkers that are carried in biofluids, especially in biofluids such as blood and saliva...
BioPhotonics, Mar/Apr 2022
Photoacoustic Remote Sensing Reveals Clues About Cancer, Blindness
As microscopic optical inspection techniques have progressed over the years, they have provided valuable insights into the composition, structure, and function of cells and subcellular structures, transforming the way researchers and clinicians look...
BioPhotonics, Mar/Apr 2022
Optical Filters Help PCR Tests Quickly Diagnose COVID-19
The need to implement technology that can rapidly diagnose diseases and pathogens accurately has never been greater than it is now, as the COVID-19 virus continues to spread around the world. Prior to 2020, most people working outside the field of...
BioPhotonics, Jan/Feb 2022
Multiphoton Exoscope Broadens Noninvasive Imaging of Skin
Skin imaging at the cellular level is critical for understanding how diseases and aging affect the skin, and for developing strategies and therapies to prevent and combat these effects in a clinical setting. Visualizing dynamic cellular and...
BioPhotonics, Jan/Feb 2022
Miniaturization in NIR Spectroscopy Reshapes Chemical Analysis
Near-infrared (NIR) spectroscopy has been used in groundbreaking research in many of the life sciences due to its capacity to rapidly determine and analyze the composition of materials. Bulky instruments with limited portability, however, have kept...
BioPhotonics, Jan/Feb 2022
The Hyperspectral Camera Looks Alzheimer’s in the Eyes
Alzheimer’s disease is one of three so-called trillion-dollar diseases, along with cancer and diabetes — meaning that financial and societal costs are approaching $1 trillion worldwide. Diagnosis has historically been a complex task, requiring...
BioPhotonics, Jan/Feb 2022
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