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FEATURES
Label-Free Live-Cell Imaging for High-Content Screening
High-content screening is the collection of multiple data parameters in parallel from the same cellular samples. It has evolved into a mature technique typically using automated fluorescence microscopy and high-resolution imaging of cells stained with multiple labels. Very little effort has been expended on analyzing bright-field images because obtaining accurate statistical data from bright-field images alone has been considered too difficult. But bright-field image analysis enables the...
BioPhotonics, November 2009
Medical Device Companies Try Peering into the Future
The past year has not been as gloomy for the medical device industry as it has, say, for home builders, automakers and just about everyone else. In the US, demand for the latest and greatest technologies to keep people healthy and happy is higher...
BioPhotonics, November 2009
Better Medicine Through Lighting
Medical doctors and dentists make visual diagnoses almost every day. They may identify a mole that needs watching, or catch signs of gum disease. The unique spectral characteristics of biological tissue cause it to vary in appearance according to...
BioPhotonics, October 2009
CARS Microscopy Made Simple
Advanced optical imaging techniques can provide unprecedented details about the dynamics of life on a microscopic level. Such techniques typically rely on fluorescent molecules introduced into cells and tissue for labeling purposes; these probes may...
BioPhotonics, October 2009
For medical imaging, a possible convergence
In the US and elsewhere, health care reform is in the news, and the economy apparently is on the mend. These developments could bode well for the medical imaging market – or, if some worst case scenarios play out, they could portend problems. The...
BioPhotonics, October 2009
Seeking Green in Bio & Medical Products
Biotech and medical industries are huge energy consumers, so when it comes to upgrading equipment, energy efficiency is a key issue. Technological advances in the latest generation of products have led to energy conservation and reduced use of...
BioPhotonics, October 2009
Crisis Rocks Medical Imaging World
“Crisis” is a word that medical professionals and scientists rarely use because it smacks of sensationalism, yet that is precisely the word used by the Society of Nuclear Medicine of Reston, Va., to describe a recent shortage of...
BioPhotonics, September 2009
Getting the Whole Picture
Sometimes you need the whole picture. In biomedical research, that means whole-animal imaging. While these techniques can’t be applied directly to clinical problems, optical whole-animal imaging can aid in research. It also can point the way to...
BioPhotonics, September 2009
Making Medical Devices and, Hopefully, Money
To apply an old saying to the commercialization of research, there’s many a slip before a product ships. Turning something developed in an academic setting into a viable medical device that can be mass-produced while hitting cost, reliability and...
BioPhotonics, September 2009
MTF Metrology for High-NA Microscope Objectives
Microscope objectives represent an interesting case in the field of imaging performance metrology. In a parallel to mainstream photographic lenses, users of microscope objectives typically are more concerned with subjective performance – i.e.,...
BioPhotonics, September 2009
Full steam ahead with the fastest camera in the world
Some biological events happen so quickly that ordinary cameras simply miss those crucial shots – of neurons firing, proteins moving and lasers performing surgery, just to name a few.Shimadzu Corp.’s HPV-1 is perhaps the fastest commercially...
BioPhotonics, July 2009
Nanophotonic Sensors
Around the world, researchers are developing nanoscale devices that receive and emit light. These devices could work better than existing methods of detecting biological molecules for research and direct medical diagnostic...
BioPhotonics, July 2009
Nanopositioning Systems: Speed is Key
The development of focus-correction devices, using a variety of techniques, is another exciting area contributing to higher-precision instrumentation devices, Con Foo said. The explosion of interest in nanoscale biotechniques has been a stimulus for...
BioPhotonics, July 2009
Picture-Perfect Analysis
Christian Kier is marketing manager for MetaMorph, an image capture and analysis package from MDS Analytical Technologies of Sunnyvale, Calif. He explained that ease-of-use improvements are a focus for the company, rather than such innovations as a...
BioPhotonics, July 2009
WHO Reviews The Review?
It was a hazy early April morning, my coffee was still brewing, and I was talking on the phone with Eugene G. Arthurs, CEO of SPIE, about the boosts provided by the Challenge Grants and other National Institutes of Health (NIH) mechanisms supported...
BioPhotonics, July 2009
Making cells stick to a nonstick surface
Teflon’s nonstick properties make it ideal for more than pots and pans. The material, also known as poly-tetrafluoroethylene, is a good choice for use in direct contact with blood because its high bond energies render it biologically inert, which...
BioPhotonics, May 2009
Optical Tweezers: Empowering Biology with the Force of Light
Over the past few years, optical tweezers increasingly have been used to answer questions of biological significance. Doing a search with key words such as “optical tweezers” and “optical trap” on the Web of Science database shows that, over the...
BioPhotonics, May 2009
The Long and Short of Biomedical Imaging
What you can’t see can hurt you. Cancer and other diseases can remain undetected until it’s too late. On the other hand, sometimes what you can’t see can help you: Increasingly, photons in nonvisible wavelengths are being used to spot disease,...
BioPhotonics, May 2009
The Stimulus Package and You
On Tuesday, Feb. 17, President Obama signed into law the American Recovery and Reinvestment Act (ARRA), the much-debated stimulus package designed to breathe life into the US economy. The act included a remarkable $10.4 billion for the National...
BioPhotonics, May 2009
These optical fibers could save lives
A start-up company is developing fibers that could provide real-time information as cardiologists open clogged arteries. Another start-up is using fibers to enable gastroenterologists to search the esophagus and colon for tissue that could become...
BioPhotonics, May 2009
Microfluidic Systems make the Impossible Possible
According to the Jan. 15, 2009, Genetic Engineering and Biotechnology News, the market for microfluidic technology will climb toward $1.9 billion over the next three years. Shown are LabChips made by Caliper for the Agilent 2100...
BioPhotonics, April 2009
Open Wide
It’s no surprise that William Brown is certain the future of lasers in dentistry is bright. After all, he is a vice president at dental laser maker Biolase Technology Inc. in Irvine, Calif. But that feeling is based on more than his job. It rests,...
BioPhotonics, April 2009
Shedding a New Light on Cancer
The recent high-profile pancreatic cancer cases of actor Patrick Swayze and Apple CEO Steve Jobs have called attention to the more than 37,000 Americans who are diagnosed with the disease each year, according to the National Cancer Institute....
BioPhotonics, April 2009
Unlocking Epilepsy’s Secrets
Their goal is to understand the epileptic brain. And the key just might be fluorescence lifetime imaging microscopy – also known as FLIM. Michael J. Levene, assistant professor of biomedical engineering at Yale University in New Haven, Conn., and...
BioPhotonics, April 2009
Laser Destroys Brain Tumors
Drs. Bernard Bendok and Andrew Fishman at Northwestern Memorial Hospital in Chicago reported in January that they had become among the first surgeons in the world to use the Beampath Neuro laser system from OmniGuide Inc. of Cambridge, Mass....
BioPhotonics, March 2009
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