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Histology Breaks a Speed Barrier
High-bandwidth sensing has brought data volumes previously unconsidered into everyday tools. Tightly coupled with this are modern, powerful computational approaches, including machine learning and scalable computation, that enable intelligent data interpretation with virtually no human in the loop. Today’s optical instruments, which have integrated software and compute layers, are outpacing human bandwidth and forcing their human designers and end users to operate more like orchestrators
BioPhotonics, Feb/Mar 2018
LED Technology Advances Endoscopy
Endoscopy is a minimally invasive medical procedure used to view or image inside the human body for surgical and diagnostic applications (Figure 1). This method was first used in the 19th century and has expanded to a wider use today, with...
BioPhotonics, Feb/Mar 2018
SPIE BiOS Highlights Biomedical Optics
SPIE BiOS has been hailed “the most important biomedical optics conference you can attend in 2018.” The world’s largest biophotonics, biomedical optics and imaging conference, it offers the latest research on topics such as...
BioPhotonics, January 2018
Endospectroscopic Imaging Takes Optical Biopsies to the Next Level
Spectroscopy has the potential to provide pathologists with fast in vivo tissue characterization to determine tumor type and grade and to delineate tumor margins. However, extending the applicability of microspectroscopy to in vivo imaging requires...
BioPhotonics, January 2018
MUSE: Simple Slide-Free Microscopy
Even in this era of molecular medicine, conventional light microscopy remains the principal contributor to cancer diagnostics and also serves to guide surgical procedures, monitor disease activity and follow therapy responses over time. Although...
BioPhotonics, January 2018
Silicone Immersion Objectives Boost 3D Live-Cell Imaging
Refractive index mismatch and resulting spherical aberration has historically plagued researchers interested in long-term, live-cell imaging at high resolution. The use of silicone oil objectives helps mitigate this mismatch, as the refractive index...
BioPhotonics, January 2018
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Terahertz Imaging Takes Aim at Dermatology and Dentistry
The first terahertz image was taken at the AT&T Bell Laboratories more than 20 years ago in 1995. The astonishingly clear image of the inside of a packaged semiconductor integrated circuit brought immense attention to terahertz imaging for...
BioPhotonics, January 2018
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3D Imaging Aids Life Sciences
While human bodies and single cells are three-dimensional, imaging of them often was not. Data might be captured in two-dimensional slices during a computed tomography, magnetic resonance, ultrasound or even microscope study. But the interpretation...
BioPhotonics, Nov/Dec 2017
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DGC Helps Illuminate Mechanisms of Alcohol Dependency
Imaging transparent, colorless specimens has always presented a challenge in optical microscopy. In many applications, it is not desirable or even possible to use fluorescent dyes, stains or transgenic probes to render target objects more visible....
BioPhotonics, Nov/Dec 2017
Full-Spectrum Technology Deepens the Reach of Flow Cytometry
Flow cytometry is gaining traction as a clinical and research tool in areas such as immuno-oncology and systems biology because it enables the ability to profile a large panel of heterogeneous cells from a single sample. These rapidly growing areas...
BioPhotonics, Nov/Dec 2017
Photomediated Ultrasound Therapy Offers Precision Targeting of Microvessels
Neovascularization and vascularization play a critical role in the pathogenesis of numerous pathological conditions, including cancer, inflammation and retinal vascular diseases. Retinal diseases such as macular degeneration and diabetic retinopathy...
BioPhotonics, Nov/Dec 2017
Laser Sintering Moves Into the Medical Market
Every patient is unique. Hence, nothing is more natural than providing each patient with a unique implant. Thanks to laser-based additive manufacturing, this is already possible. Patient-specific titanium implants manufactured by laser sintering,...
Photonics.com, September 2017
UVC LEDs Can Combat Hospital-Acquired Infections
The Centers for Disease Control and Prevention (CDC) reports that one in every 25 hospital patients in the U.S. will contract a hospital-acquired infection (HAI) during their visit. Recent CDC reports show that progress is being made in HAI...
BioPhotonics, October 2017
3D Mapping of Neural Circuits In Vivo Opens the Window on Neurological Disease
Despite extensive research, brain function and neurological diseases are poorly understood. Complexities arise from the quantity of neurons in the brain and from the densely interconnected networks of intermixed cell types. Tools neuroscientists...
BioPhotonics, October 2017
Single-Molecule Localization Blazes New Paths for Microscopy
Fluorescence microscopy has proven itself to be an indispensable method in the modern biological toolkit. The use of visible-wavelength fluorophores allows for relatively noninvasive imaging. While the resolution of conventional optical microscopy...
BioPhotonics, October 2017
Forensic Microscopy Expands Its Reach
The field of forensic microscopy is more than a century old. Though practitioners say their profession is far less glamorous than its portrayal in popular TV crime and courtroom shows, forensic investigation remains a powerful tool for learning the...
BioPhotonics, October 2017
Embedded Vision Moves Into the Clinical Realm
Embedded vision, the combination of miniaturized processing units and board-level cameras, has the potential to create a new tool for medical monitoring and diagnostics. The hardware design can make medical devices faster, more compact and more...
BioPhotonics, September 2017
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Cardiac Optogenetics Seeks to Fulfill Its Promise
The next decade is going to be a telling one for those working in pursuit of cardiac optogenetics. Initial proofs have been demonstrated, the optical tools have been developed and scientific evidence has grown to a point where the tremendous...
BioPhotonics, September 2017
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Pulsed Laser Diodes Can Hasten Clinical Use of Photoacoustic Imaging
Through hundreds of publications and conference papers each year, photoacoustic imaging (PAI) has been shown to have potential for early detection of afflictions such as skin and thyroid cancer, cardiovascular disease, and arthritis. The noninvasive...
BioPhotonics, September 2017
Making the Connection: Optics, Neural Activity and Behavior
An international army of neuroscientists is trying to better understand the inner workings of the brain by exploring the correlations between neural activity and behavior of freely moving or partially restrained lab animals. The best method for...
BioPhotonics, September 2017
In Dermatology, Lasers Offer Options For Medical, Cosmetic Procedures
From skin cancer diagnosis and treatment to wrinkle removal and skin rejuvenation, laser-based treatments increasingly offer noninvasive alternatives to traditional procedures. These noninvasive alternatives can lessen tissue damage, decrease...
BioPhotonics, Jul/Aug 2017
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Spectroscopy and the Holy Grail
For more than 30 years, scientists have sought a reliable noninvasive method to monitor blood sugar — for good reason. Invasive testing requires taking blood samples, either through blood draws at the lab or, for known diabetics, testing at home...
BioPhotonics, Jul/Aug 2017
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Smartphone Fluorescence Microscopy Allows Cost-Effective Molecular Diagnostics
Lack of diagnostic tools in resource-limited settings remains one of the major obstacles to disease diagnosis and treatment in the developing world. Although significant progress has been made in the availability of highly sensitive and specific...
BioPhotonics, Jul/Aug 2017
Intelligent Hyperspectral Imaging Holds Promise for Pathology
Hyperspectral imaging (HSI) provides images with numerous spectral bands over a continuous spectral range, enabling analysis of complex scenes that contain both spectral and spatial information. These imagers tend to be expensive and often require...
BioPhotonics, Jul/Aug 2017
Interweaving Photonics Research, Industry
Laser World of Photonics provides a spotlight for promising newcomers, industry veterans and innovative companies. And with tens of thousands of people from countries around the globe attending the show, that spotlight is huge. In 2015, the biennial...
Photonics.com, June 2017
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