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Nanotechnology and Photonics Join Forces in Biomedicine
In the recent past, biology has shifted from the microscale to the nanoscale, from the level of the cell to that of viruses and of cellular constituents such as proteins, nucleic acids and most organelles. By extension, tools for the investigation of these constituents and viruses must operate on the same scale. Therefore, scientists have turned to nanotechnology for imaging biological processes, for analyzing biological materials and for fighting disease. In many cases, scientists use...
BioPhotonics, April 2008
Raman Spectroscopy Analysis of Polymorphs
Some molecules with the same chemical formula can have different crystal structure forms — called polymorphs. There are two ways in which crystal structures can arise: arrangement (or packing) polymorphism and conformational polymorphism....
BioPhotonics, April 2008
Raman Spectroscopy Meets Flow Cytometry
In flow cytometry, which performs high-speed optical analysis of single cells, suspensions of cells are hydrodynamically focused single file through a laser beam (Figure 1). The light scatter provides information about gross morphological features...
BioPhotonics, April 2008
Tip-Enhanced Raman Spectroscopy for Bioanalysis
A fundamental goal in the life sciences is to understand how the elemental building blocks (nucleobases, amino acids, etc.) are composed in living organisms. Chemical processes in cells are carried out by macromolecules such as nucleic acid chains,...
BioPhotonics, April 2008
Detecting Colon Cancer, Virtually
For scientists researching ways to prevent death, colon cancer offers a tempting target because screening techniques can spot precancerous tissue, and it is known which part of the population should be checked. And even though benign lesions (known...
BioPhotonics, March 2008
Hyperspectral Imaging for the Life Sciences
Multispectral and hyperspectral imaging techniques were developed for applications in remote sensing and astronomy but have slowly transitioned into use in many areas of the life sciences, including fluorescence microscopy and in vivo imaging....
BioPhotonics, March 2008
The Quest for a Better Biological Imaging System
Imaging biological systems on the cellular and even molecular level requires a material that is as versatile as it is durable. Quantum dots possess many of the attributes necessary for this purpose. The strengths of these nanosize semiconductors...
BioPhotonics, March 2008
LEDs for Fluorescence Microscopy
Until recently, fluorophore excitation has been achieved using broad-spectrum mercury gas discharge lamps with a combination of optical filters to remove many of the unwanted wavelengths. These lamps are widely used and accepted in microscopy...
BioPhotonics, February 2008
New Developments in SPR Biosensing
Surface plasmon resonance (SPR) biosensors have been developed for a variety of applications, from early diagnosis of disease to drug discovery and from water purity analysis to identification of pathogens possibly used for bioterrorism. Offering...
BioPhotonics, February 2008
Raman Analysis Speeds into Biomedicine
Raman is one of a number of spectrographic techniques that may be used to study biological materials. Of these, dispersive Raman imaging offers a compelling range of capabilities, providing superior chemical specificity with excellent spatial...
BioPhotonics, February 2008
CMOS Cameras Enter the Life Sciences Market
When a rat decides on a course of action, you can’t ask it what factors played a role in that decision. But Jason Ritt, a postdoctoral fellow at the McGovern Institute for Brain Research at MIT in Cambridge, Mass., had to get as close as possible to...
BioPhotonics, January 2008
Fiber Optics and MEMS
During the past 16 years, nonlinear optical microscopy has evolved from a photonic novelty to a well-established laboratory tool. Rapid development of fiber optic components with growing functionalities and decreasing size provides enormous...
BioPhotonics, January 2008
Fiber Optics in Surgery
One of the vital steps of most surgical procedures is bonding the edges of human tissue. Surgeons use sutures, staples or adhesives to close incisions in tissue, which encourages natural wound healing processes. An alternative method, which has been...
BioPhotonics, January 2008
Highly Stable UV Fiber
Raman spectroscopy with in situ UV optical fiber probes, UV confocal laser scanning microscopy using optical fiber-laser coupling, and UV fiber optic spectroscopy for gas chromatography are just a few of the applications using optical fiber as a...
BioPhotonics, January 2008
Rare-Earth Doped Nanocrystals for Biosensing and Imaging
There has been a great deal of interest in the fabrication and characterization of highly luminescent nanoparticles because of their potential applications as nanosensors and as biosensors for applications such as molecular diagnostics. The organic...
BioPhotonics, January 2008
The New x in FTTx
The term FTTx is shorthand for fiber to the x, with the x being a particular destination, such as the desk or the home. This term is taking on new meaning as optical fiber has extended into many new and challenging medical and surgical applications....
BioPhotonics, January 2008
Thulium Fiber Lasers
The use of lasers as medical instruments has increased dramatically in recent years because of the growing acceptance and efficacy of laser procedures as an alternative to traditional surgeries. A recent market report by Frost & Sullivan, a...
BioPhotonics, January 2008
AFM Reveals Biological Mechanisms
Some of the latest atomic force microscopy (AFM) research demonstrates that the technique can provide information about the molecular composition of protein complexes and can show how something as tiny as a retrovirus, such as HIV, replicates in...
BioPhotonics, December 2007
Clipped to a Shark’s Fin, Collared to a Bear or Attached to a Crow’s Tail, Wildlife Cameras Come of Age
When the finishing touches were put on the first Crittercam 20 years ago, the device more or less resembled a camera. It did take pictures, and it was attached successfully to a loggerhead sea turtle. But those early models — 2 ft long, weighing...
BioPhotonics, December 2007
LEDs for Bioanalytical and Medical Instruments
The much-anticipated availability of LEDs for applications in biophotonics finally is manifesting itself in a new selection of more efficient, longer-lived illumination products. LEDs have long held promise as a simple, low-cost alternative to...
BioPhotonics, December 2007
New Directions in FRET
Förster resonance energy transfer (FRET) continues to provide researchers with a means to quantify protein-protein interactions and other molecular dynamics by labeling molecules with a donor and an acceptor, which give off a characteristic emission...
BioPhotonics, December 2007
A Brighter Red, a Simpler Green and Structural Understanding
Fluorescent proteins are essential tools for probing and understanding biochemical processes as they happen. And as any mechanic or handyman knows, you have to have the right tool for the job. That is why research into the development of new...
BioPhotonics, November 2007
Engineer-Physician Collaboration Model Aids Biophotonics in Medicine
The direct application of engineering to medicine is a notable trend of the past decade. Noninvasive diagnostic technologies, high-resolution imaging, advanced materials implants and controlled-release drug delivery systems are just a few examples...
BioPhotonics, November 2007
OCT Could Enable Noninvasive Diabetes Monitoring
The majority of diabetes patients must prick themselves several times a day to monitor their glucose level. They then self-administer insulin or medication to ensure that their level remains within the appropriate range. Several light-based...
BioPhotonics, November 2007
OCT Imaging for Cochlear Surgery
Cochlear implants are used to stimulate directly the nerve structures in patients with nonfunctional receptor cells. Such electrodes traditionally have been used only in deaf patients, but recently these devices have been implanted in patients with...
BioPhotonics, November 2007
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