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BioPhotonics - Nov/Dec 2022


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Features
Innovations in the STORM Method Reveal Vital Clues to Disease Formation Scientists and clinicians have long believed that visualizing structural changes in the nucleus of cancer cells would unlock vital clues about how the disease first forms. This information could provide the ability to track where and how cancer is progressing to plan its successful treatment. Traditional microscopy methods have fallen short in revealing these details because the microscope’s...
The Evolution of Scientific Cameras Leads to the Advancement of Microscopy Most people are familiar with standard qualitative cameras and bright high-contrast images, thanks to the prevalence of increasingly powerful smartphone and digital cameras in the marketplace....
Portable Reflectance Confocal Microscopy for Low-Resource Settings Reflectance confocal microscopy (RCM) is an optical imaging technology that captures reflected light from tissue to visualize the tissue’s cellular morphologic details. The method does not require...
Editorial
Early warning signs This year’s Heinrich Wieland Prize recognized Harvard University professor Xiaowei Zhuang for her lab’s development of stochastic optical reconstruction microscopy (STORM), a technology that continues to bear fruit in the life sciences. Researchers have been using the superresolution method for more than 15 years, along with other techniques that break the Abbe limit, to improve their...
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SPIE BiOS to Highlight System Design and Early Diagnostics As part of SPIE Photonics West 2023, which will take place at the Moscone Center in San Francisco, the BiOS Expo will run the weekend of Jan. 28-29. The exhibition will include dozens of companies showcasing new photonic system components and the latest adaptations for optical technologies in medicine and the life sciences. BiOS Hot Topics sessions will cover image-guided autonomous robotic...
BioScan
Technique Enables In Vivo Vascular Imaging at Single-Cell Resolution A two-photon fluorescence imaging method developed by researchers at the University of Hong Kong and the University of California, Berkeley was able to image the flow of individual blood cells at 1000 2D frames and 1,000,000 line-scans per second in the brains of awake mice. Such rapid measurements go beyond the reach of conventional two-photon microscopy methods to enable the study of blood flow...
Nanotech, Deep Learning Combine to Detect Pediatric Tuberculosis A technique for diagnosing tuberculosis (TB) in children takes advantage of the optical properties of gold nanoparticles to detect the disease. The technique uses an artificial intelligence (AI)...
IDEX Adds Muon Group to Health & Science Technologies Segment IDEX Corp. has entered into a definitive agreement to acquire micro-precision technology manufacturing company Muon BV (Muon Group) and its subsidiaries. The deal is worth €700 million (~$699.13...
Flow Cytometry Technique Shows Promise for Early Cancer Diagnosis A digital droplet microfluidic flow cytometry technique could enable earlier recognition of tumor development and progress, by aiding in the detection of multiple microRNAs (miRNAs) in single...
Expansion Microscopy Technique Reveals Hidden Nanostructures Proteins and other molecules are often tightly packed together inside a living cell. These dense clusters can be difficult to image because the fluorescent labels used to make them visible...
Olympus Sells Scientific Solutions Business to Bain Capital Olympus is selling its wholly owned subsidiary EVIDENT Co. Ltd. to Bain Capital. The divestment, which is reportedly worth over $3 billion, will see all shares of EVIDENT transferred to Bain Capital...
Imaging Method Noninvasively Measures Placental Health An optical technique for measuring placental blood flow and oxygenation in real time provides information about placental hemodynamics that could aid in the early detection of adverse pregnancy...
SPIE Elects de Groot into its Presidential Chain Peter de Groot, chief scientist at Zygo Corp., was elected to serve as the 2023 vice president of SPIE. The election brings de Groot into the SPIE presidential chain. He will serve as president-elect...
Optogenetic Tools Use Blue Light to Restore Cell Function Researchers from the University of Cincinnati (UC), the University of Illinois Urbana-Champaign (UI), and the University at Buffalo (UB) used an optogenetic technique to bring together mitochondria...
Arizona Commerce Authority Awards $1.6M for Wearables Research The Arizona Commerce Authority awarded $1.6 million to support eight applied research projects through the Partnership for Economic Innovation’s (PEI) WearTech Applied Research Center. The...
BD, Labcorp Collaborate on Flow Cytometry-Based Diagnostics Medical technology company BD (Becton, Dickinson and Company) announced a collaboratation agreement with life sciences company Labcorp to develop flow cytometry-based companion diagnostics intended...
Portable Laser-Based Scanning Device Detects Critical Biomarkers Researchers at the University of Arkansas for Medical Sciences (UAMS) reported advances to the previously developed Cytophone device. In the current work, the researchers integrated a miniature...
European Initiative to Establish Standards for Diffuse Optics A collaboration between 12 European institutions aims to deliver performance assessment and standardization (PAS) in the field of diffuse optics (DO). DO analyzes how light is absorbed and scattered...
3 Questions
3 Questions with Kevin Zhou BioPhotonics spoke with Kevin Zhou, a postdoctoral fellow in the Biomedical Engineering Department at Duke University, who received the Barry Goldwater Scholarship, the National Science Foundation Graduate Research Fellowship, and the Schmidt Science Fellowship. Zhou and his colleagues recently published a paper about a new computational 3D microscopy method — called 3D optical coherence...
BioOpinion
Cosmetic clinical trials must be planned with diversity as a priority Medical research has a long, unfortunate track record of excluding ethnic and racial minority groups from clinical trials, a phenomenon that introduces remarkable uncertainty to the outcomes of taking medications or receiving laser-based medical treatments in these populations. Similarly, chronic medical conditions and adverse reactions to treatment that disproportionately affect minority groups,...
Postscripts
Float like a jellyfish, sting like a jellyfish How animals survive in the wild and defend themselves from natural predators is one of the most fascinating and essential mechanisms that researchers can study. Because animals cannot rely on the same mental strategies that humans can to extract themselves from dangerous situations, the animals often need to take advantage of innate physical capabilities. Photonics, in conjunction with other...
Products
Surgical Visualization Platform The VISERA ELITE III surgical visualization platform from Olympus Corp. is designed for endoscopic procedures across multiple medical disciplines. Minimally invasive therapies are enabled,...
Olympus Corp.
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Blue Laser Diode The FNV-402-3000M laser diode from Frankfurt Laser Co. is a high-power, 402-nm blue laser diode that delivers output power of >3W. Built in a compact 9-mm TO can SOT-148, the device offers...
Frankfurt Laser Company
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Beam Profiling Camera The Ophir SP504S Beam Profiling Camera from MKS Instruments Inc. measures large and divergent beams by accurately capturing and analyzing wavelengths from 340 to 1100 nm for beam sizes from 45...
MKS Ophir, Light & Measurement
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Particle Image Velocimetry System A Particle Image Velocimetry (PIV) system has been announced by Microvec Pte. Ltd., designed for measurements in air and water with velocities of up to 200 m/s. The fully functional system...
Microvec Pte. Ltd.
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Radiation-Resistant Optical Fiber The Optran® UV NSS Fiber from Armadillo SIA provides deep-UV solarization and radiation resistance. The optical fiber features a hermetic carbon layer, low numerical aperture expansion, and...
Armadillo SIA
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Optical Spectrum Analyzers The AQ6375E and AQ6376E optical spectrum analyzers from Yokogawa Europe BV, Test & Measurement combine short- and mid-wavelength IR with extreme optical precision to aid in the development of...
Yokogawa Europe BV
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Scientific Camera The Phantom T2410 scientific camera from Vision Research Inc. offers ultrahigh frame rates of 24 GP/s. The device delivers backside illumination technology and identical imaging performance as...
Vision Research Inc., Phantom Digital High-Speed Cameras
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Raman Interface The inLux™ scanning electron microscope (SEM) Raman interface from Renishaw PLC enables in situ Raman spectroscopy for highly specific chemical and structural characterization. The...
Renishaw PLC, Spectroscopy Products Div.
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Image Analysis Tool The Aivia 11 artificial intelligence-powered image analysis tool from Leica Microsystems GmbH features a deep learning-based cell segmentation algorithm that offers advanced insight creation...
Leica Microsystems GmbH
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Holotomography Microscope The HT-X1 high-resolution holotomography microscope from Tomocube Inc. features an incoherent light source and is suited for higher-throughput and automated screening applications. The device...
Tomocube Inc.
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