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BioPhotonics - Jan/Feb 2024


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Features
Stimulated Raman Photothermal Microscopy Provides Ultrahigh Sensitivity Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing molecular structures, dynamics, and couplings in complex systems. Yet, the sensitivity of SRS is fundamentally...
Optical Filters Narrow the Focus of Raman Biomedical Analysis While Raman spectroscopy has long been useful in pharmaceutical analysis and the identification of hazardous materials, the technology’s usefulness in biomedicine has also been expanding due to...
Virtual Histology: Democratizing Diagnostic Anatomic Pathology Histology is the microscopic examination of stained and sectioned cells and tissue. Traditional histological examination requires a sequence of essential sample processing steps, including fixation,...
Time-Domain Functional NIRS Traces Map of Brain Activity Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical investigative technique in neurology to map localized brain activity, during which the brain signal is derived from measured...
Editorial
With a new year, a new look to our magazine Welcome to the new look of BioPhotonics! We’re thrilled to have you as readers and hope our improved appearance enhances your visual experience, and your enjoyment, while learning about the latest in biomedical optics and life sciences research. Our January/February edition features a more modern appearance. And the redesign of our publication is coinciding with the launch of our dedicated...
BioScan
PerkinElmer Acquires Covaris PerkinElmer has acquired biotechnology company Covaris, in a move that PerkinElmer said will expand its existing life sciences portfolio into the high-growth diagnostics end market. Covaris is a developer of high-throughput genomic and proteomic analysis instruments, consumables, and reagents. Its solutions aim to enable research and drug discovery for clinical diagnostics, biopharma, and...
Evident, Partners Advance Live-Cell Imaging Instrumentation Life science imaging systems producer Evident has collaborated with illumination and imaging technology company 89 North and advanced microscopy systems producer CrestOptics to promote confocal...
Algorithm Boosts Live-Cell Imaging's Capabilities Superresolution radial fluctuations (SRRF), a superresolution algorithm, works by observing fluctuations in radial symmetry throughout the frames of an image. SRRF supports live-cell, superresolution...
Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of...
Algorithm Targets Microscope Resolution Scientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the...
Center for Photonics in Infection Research to Open in Jena Germany’s Federal Ministry of Education and Research is funding the establishment of the Leibniz Centre for Photonics in Infection Research (LPI) at the Jena University Hospital. The center...
Low-Power Optical Tweezers Protect Bioparticles from Damage Optical tweezers trap and manipulate minute particles with light. The technology is used across fields, ranging from manufacturing to biotech, though it requires the use of high-powered lasers to...
Lasers Improve Phototherapy-Drug Delivery Platform Photoimmunotherapy targets cancer cells with microscopic, nano-engineered cancer drugs that are light-activated at the lesion site. Although the technology is increasingly used to treat metastatic...
Flexible Optogenetic Tool Blocks Pain, Not Movement Engineers at MIT have developed soft and implantable fibers that can deliver light to major nerves through the body. When these nerves are genetically manipulated to respond to light, the fibers can...
Beamforming Reduces Photoacoustic Image Bias Photoacoustic (PA) imaging offers a noninvasive means to obtain molecular and functional information about a variety of medical conditions. However, the quality of PA images, which are acquired when...
Deep Learning Delivers Optoacoustic Images in Real Time High-quality medical imaging from multispectral optoacoustic tomography (MSOT) could be used to diagnose and evaluate a range of diseases, including breast cancer, Duchenne muscular dystrophy, IBD,...
Microscopy Method Detects Treatment-Resistant Cancer Therapy-induced senescent (TIS) cells are cancer cells that become resistant to therapies and enter a dormant stage. These cells can emerge from dormancy and induce tumor resistance and relapse. To...
Wearable Sensor Could Detect Postpartum Blood Loss Postpartum hemorrhage, the leading and most preventable cause of maternal mortality, can be hard to detect, because physiological compensation mechanisms can mask excessive bleeding. In the early...
3 Questions
Three Questions with Courtney Schkurko BioPhotonics spoke with Courtney Schkurko, engineering project manager at NASA Glenn Research Center in Cleveland, Ohio, who specializes in spaceflight exploration medical technology development and demonstrations. She has a bachelor’s degree in electrical engineering from Ohio Northern University. NASA recently tested the Reusable Handheld Electrolyte and Laboratory Technology for Humans...
BioOpinion
Online or In-Person: How Do We Connect and Engage? Most of what we know about how the human brain functions is based on studies of brain activity in single individuals under very controlled parameters. Conventional neuroimaging is performed in a scanner environment using functional magnetic resonance imaging (fMRI) in which participants are constrained in an MRI bore that includes loud high-pitched noises, a head-mounted contraption conducive to...
Postscripts
Shining a light on sleep disturbance A good night’s sleep can depend on many factors. Physical stressors, such as loud noises or extreme light, might interrupt sleep patterns temporarily, but underlying medical conditions, specifically stress-related diseases, can have long-term health implications. While it sounds counterintuitive, clinical evidence suggests that to alter sleep patterns for the better, it is a good idea to turn the...
Products
Laser Active Elements Er:YAG Laser Active Elements operate at 2940 nm, and the lasers are well known for their ability to deliver precise ablation while minimizing thermal damage to surrounding tissues. These laser active...
Meller Optics Inc.
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4K Digital Microscope The TAGARNO T50 from TAGARNO is a 4K digital microscope that uses Sony ISS’s FCB-ER9500 camera. The collaboration allows for a digital microscope that can capture live images at 60 fps. The...
TAGARNO
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Laser Scanning Microscopes Evident’s FLUOVIEW™ FV4000 confocal laser scanning microscope and FV4000MPE multiphoton laser scanning microscope, feature advancements in imaging technology that empower researchers to...
Evident
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UV-C Germicidal Radiometer Kit The UV-C germicidal radiometer kit from Gigahertz-Optik features the X1-UV-3725 radiometer, UV-3725-4 254 nm UV-C detector, UV-37xx-Z01 80° field of view adapter, and K-UV3725-S irradiance...
Gigahertz-Optik Inc.
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Portable Wideband Laser The SLP-1000 from SuperLight Photonics is a portable wideband laser. Based on Patterned Alternating Dispersion™, it has a coherent and stable spectral output of 400 nm at -3 dB and 1500 nm at...
SuperLight Photonics BV
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Fiber Coupled Antennas The TERA15-HP-TX from Menlo Systems are high-power fiber-coupled broadband terahertz (THz) antennas that generate more than 300 µW on average The antennas produce more than 6 THz bandwidth and...
Menlo Systems GmbH
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Liquid Flow Meter The Micro Flow Meter from Biotech Fluidics is designed to continuously monitor ultralow fluidic flows in real time. Made to operate over the 100 nl to 80 µL/minute flow range with a resolution...
Biotech Fluidics AB
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Microspectrophotometer The FLEX PRO™ from CRAIC Technologies is a microspectrophotometer that combines UV-Visible-NIR microspectroscopy and imaging. It offers features that allow for flexible and precise measurements...
CRAIC Technologies
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Microfluidic System The MassFluidix® High Concentration microfluidic system from Refeyn extends mass photometry to high-concentration samples. The system enables accurate measurement of low-affinity biomolecular...
Refeyn Ltd.
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Carbon Dots The line of carbon dots from Alfa Chemistry are carbon-based zero-dimensional material in water-soluble and oil-soluble form. They have a wavelength range of 415 - 570 nm and have quantum yields of...
Alfa Chemistry
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Motorized XYZ Deck The HZ106 from Prior Scientific is a motorized XYZ deck created for researchers studying a range of samples from whole animal invivo studies to slides and petri dishes. Combining a dual 50 mm travel...
Prior Scientific Inc.
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Spectral FastFLIM Module The Parallel 16-PMT Spectral FastFLIM from ISS is a time-resolved spectral detector with parallel 16-channel digital frequency domain FLIM (FastFLIM) readouts for fast spectral FLIM data acquisition....
ISS Inc.
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Mid-Infrared QCLs The sQCL and LaserTune-S from Block Engineering are compact mid-infrared quantum cascade lasers (QCLs) that offer a six-fold increase in laser power, orders of magnitude better thermal and temporal...
Block Engineering
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Direct-Drive Rotation Stages The V-622, V-623, and V-625 from PI are high-performance rotary stages equipped with frictionless electromagnetic torque motors and precision ball bearings. The V-62x family comes with table...
PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
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