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Optical Measurements Combine for Early Metastasis Detection

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Diffuse in vivo flow cytometry (DiFC), an optical technique developed at Northeastern University, enables fluorescence detection of tumor cells circulating in the bloodstream. It is a promising technique for detecting cancer that has metastasized. However, due to signal-to-noise ratio (SNR) constraints, which are attributed mainly to background autofluorescence in the tissues, DiFC’s measurement depth is limited. A team from Tufts University and Northeastern University is working to address this issue and take the DiFC method developed by the Northeastern group to a new level. The...Read full article

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    Published: August 2023
    Glossary
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    flow cytometry
    Flow cytometry is a powerful technique used in biology and medicine for the quantitative analysis of the physical and chemical characteristics of cells and particles suspended in a fluid. The method allows for the rapid measurement of multiple parameters simultaneously on a cell-by-cell basis. It is widely used in various fields, including immunology, microbiology, hematology, and cancer research. Here are the key components and features of flow cytometry: Sample preparation: Cells or...
    Research & TechnologyeducationAmericasTufts UniversityNortheastern Universitysignal to noise ratiospectroscopyfluorescencenear infraredImagingin vivo imagingflow cytometryLight SourcesOpticsTest & MeasurementBiophotonicscancermedicalLasersSensors & Detectorsdiffuse in vivo flow cytometryBioScan

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