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Glowing Molecules Turn On, Off to Visualize Cell Activity

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CORAL GABLES, Fla., Aug. 17, 2012 — Using UV light to switch fluorescent molecules on and off in aqueous environments could help scientists develop better fluorescent probes for biomedical research. The molecules first must be strategically trapped inside water-soluble particles, which isn't new; water-soluble particles have been used in previous studies to bring organic molecules into water. What is new in this system, developed by University of Miami scientists, is the addition of the photoswitching mechanism. "Finding a way to switch fluorescence inside cells is one of the main challenges in the development of...Read full article

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    Published: August 2012
    Glossary
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    ultraviolet
    That invisible region of the spectrum just beyond the violet end of the visible region. Wavelengths range from 1 to 400 nm.
    Americasaqueous environmentsBasic Sciencebioimagingbiomedical researchBiophotonicsFloridafluorescencefluorescent molecule switchingfluorescent probesFrancisco RaymoImagingmolecule trappingnanonanoparticlesOpticsphotonicsphotoswitchingResearch & Technologyultravioletultraviolet lightUniversity of MiamiUV lightvisible lightwater-soluble particles

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