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Features
Lensless Cameras May Offer Detailed Imaging of Neural Circuitry
Understanding brain function at the scale of individual neurons could open the door for advanced understanding of animal and human behavior and the mechanisms of neurological disorders such as Alzheimer’s. But the size scale of neurons and their extremely large numbers create an extreme imaging challenge. Calcium imaging enables optical monitoring of the action potential of individual neurons, resulting in maps of neural circuitry in living brains. To achieve this, calcium-sensitive
BioPhotonics, Jul/Aug 2018
Fluorescence Microscopy Unravels Morphogenesis, Function of Lymph System
The lymphatic system is an underinvestigated part of the vascular system. A team led by Friedemann Kiefer at the European Institute for Molecular Imaging (EIMI) at the University of Münster in Germany is aiming to change that in ongoing studies...
BioPhotonics, Jul/Aug 2018
Double-Helix Point Spread Function Delivers Precise Extended-Depth Microscopy
Light microscopy is a powerful method used in many scientific disciplines, including the life sciences, to visualize finer details in samples. The use of fluorescence enables specific targeting and labeling of biomolecules and other chemicals....
BioPhotonics, Jul/Aug 2018
Member Exclusive
Point-of-Care Optics Helps Halt the Spread of Infectious Diseases
Early diagnosis is the critical starting point to a better outcome for a patient. It allows effective treatment to start earlier, giving the patient the best possible prognosis. Prompt diagnosis also reduces the potential spread of infection,...
BioPhotonics, Jul/Aug 2018
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3D Printing Creates Patient-Specific Implants
Every patient is unique. Hence, nothing is more natural than providing each patient with a unique implant. Thanks to laser-based additive manufacturing, this is already possible. Patient-specific titanium implants manufactured by laser sintering,...
BioPhotonics, May/Jun 2018
The McCree Curve Demystified
Urban and periurban agriculture is rapidly becoming part of local economies. It is supported by increased consumer demand and preference for high-quality, locally produced foods. Socially, it is reacquainting people with food and the farm, and it is...
BioPhotonics, May/Jun 2018
Raman Hyperspectroscopy Shows Promise for Diagnosis of Alzheimer’s
Raman hyperspectroscopy combined with advanced statistics is uniquely suitable for characterizing microheterogeneous systems. Understanding the structure and biochemical composition of samples at the microscopic level is important for many practical...
BioPhotonics, May/Jun 2018
Nonconfocal 3D Microscopy Combines Real-Time Images with Depth of Focus
Stereo 3D microscopes produce real-time 3D images, but they are usually limited to low-magnification applications, such as dissection. Most compound light microscopes produce flat, 2D images because high-magnification microscope lenses have...
BioPhotonics, May/Jun 2018
Multiphoton Microscopy Sets the Standard for Live-Cell Imaging
Multiphoton imaging is widely used for live-cell imaging. Many of the applications are in neuroscience, where the overarching trends involve deeper imaging using longer wavelengths. These trends are the leading drivers behind the latest generation...
BioPhotonics, April 2018
Vying for Dominance: Swept-Source vs. Spectral-Domain OCT
Optical coherence tomography (OCT) is among the most widely used in vivo optical diagnostic techniques. This high-resolution 3D imaging modality, with market size approaching $1 billion, has established itself as an indispensable tool for...
BioPhotonics, April 2018
Remote Noninvasive Sensor Monitors Multiple Bioparameters
Photonic-based sensing is an evolving field that provides a large variety of possible biomedical applications for home care diagnosis. Various aspects of light and photons can grant us the ability to create smart sensors based on imaging tools for...
BioPhotonics, April 2018
Member Exclusive
SMS Reveals Hidden Behaviors
It was 28 years ago that the first optical experiments to detect a single molecule took place in the Moerner Laboratory at IBM Research, with relatively esoteric, low-temperature, high-resolution spectral measurements. Since then, room-temperature...
BioPhotonics, April 2018
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Biomedical OEM Lasers Meet Trends in Therapeutics
Lasers service a diverse range of biomedical applications, ranging from cosmetic fat removal and eyesight-saving photocoagulation to clinical blood cell counting. The major market driver for medical therapeutics has long been the aging “baby...
BioPhotonics, Feb/Mar 2018
Prism Awards Honor Industry’s Top Innovators
What do the world’s smallest FTIR spectrometer and a smartphone add-on sensor for noncontact bioimaging have in common? The 2018 Prism Awards for Photonics Innovation. These products are among 30 finalists for the awards that recognize the...
BioPhotonics, January 2018
Member Exclusive
Bio-Inspired Photonics Comes Full Circle
Nothing compares with nature’s ability to design complex biological organisms and structures, refined by eons of evolution. Natural design has inspired scientists for centuries to try to imitate natural phenomena such as the sticky grip of a...
BioPhotonics, Feb/Mar 2018
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Polarization-Resolved CRS Reveals Lipid Disorder at the Molecular Scale
The neurosciences are still searching for imaging methods capable of better assisting researchers and clinicians with accurate diagnoses, appropriate treatments and a greater understanding of the origin of neurological diseases. Recent imaging...
BioPhotonics, Feb/Mar 2018
Histology Breaks a Speed Barrier
High-bandwidth sensing has brought data volumes previously unconsidered into everyday tools. Tightly coupled with this are modern, powerful computational approaches, including machine learning and scalable computation, that enable intelligent data...
BioPhotonics, Feb/Mar 2018
LED Technology Advances Endoscopy
Endoscopy is a minimally invasive medical procedure used to view or image inside the human body for surgical and diagnostic applications (Figure 1). This method was first used in the 19th century and has expanded to a wider use today, with...
BioPhotonics, Feb/Mar 2018
SPIE BiOS Highlights Biomedical Optics
SPIE BiOS has been hailed “the most important biomedical optics conference you can attend in 2018.” The world’s largest biophotonics, biomedical optics and imaging conference, it offers the latest research on topics such as...
BioPhotonics, January 2018
Endospectroscopic Imaging Takes Optical Biopsies to the Next Level
Spectroscopy has the potential to provide pathologists with fast in vivo tissue characterization to determine tumor type and grade and to delineate tumor margins. However, extending the applicability of microspectroscopy to in vivo imaging requires...
BioPhotonics, January 2018
MUSE: Simple Slide-Free Microscopy
Even in this era of molecular medicine, conventional light microscopy remains the principal contributor to cancer diagnostics and also serves to guide surgical procedures, monitor disease activity and follow therapy responses over time. Although...
BioPhotonics, January 2018
Silicone Immersion Objectives Boost 3D Live-Cell Imaging
Refractive index mismatch and resulting spherical aberration has historically plagued researchers interested in long-term, live-cell imaging at high resolution. The use of silicone oil objectives helps mitigate this mismatch, as the refractive index...
BioPhotonics, January 2018
Member Exclusive
Terahertz Imaging Takes Aim at Dermatology and Dentistry
The first terahertz image was taken at the AT&T Bell Laboratories more than 20 years ago in 1995. The astonishingly clear image of the inside of a packaged semiconductor integrated circuit brought immense attention to terahertz imaging for...
BioPhotonics, January 2018
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3D Imaging Aids Life Sciences
While human bodies and single cells are three-dimensional, imaging of them often was not. Data might be captured in two-dimensional slices during a computed tomography, magnetic resonance, ultrasound or even microscope study. But the interpretation...
BioPhotonics, Nov/Dec 2017
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DGC Helps Illuminate Mechanisms of Alcohol Dependency
Imaging transparent, colorless specimens has always presented a challenge in optical microscopy. In many applications, it is not desirable or even possible to use fluorescent dyes, stains or transgenic probes to render target objects more visible....
BioPhotonics, Nov/Dec 2017
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