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Chip-on-Tip Technology Expands Endoscopy’s Use in Localized Procedures
Many patients would prefer to undergo surgery in which tools enter their bodies through a natural opening or small incision, over an operation involving the opening of their chests or abdominal cavities. Improvements in medical imaging over the past few decades have allowed for many procedures that use the former method. Endoscopy is the technique that has enabled doctors and their patients to make this choice. Many types of medical imaging — including x-rays, ultrasound, computed tomography...
BioPhotonics, Jan/Feb 2021
Photoacoustic Imaging Identifies Transplantable Kidneys
Chronic kidney disease is a condition that causes the gradual loss of kidney function over a period of months to years. The prevalence of the disease is worsened by the alarming rise of diabetes and hypertension, two of the most common causes of...
BioPhotonics, Jan/Feb 2021
Mobile Spectroscopy Enables Noninvasive Blood Hemoglobin Assessments
As one of the most routinely performed laboratory tests, a blood hemoglobin test is used to measure levels of the oxygen-carrying protein in the blood. Potentially reduced levels are commonly associated with certain conditions. Clinics order the...
BioPhotonics, Jan/Feb 2021
Spectroscopy Guides Precision Medicine
Raman spectroscopy captures the effect when light partially scatters inelastically as it interacts with matter. The amounts of energy transferred between photons and molecules during this process correspond to specific molecular vibrations....
BioPhotonics, Nov/Dec 2020
Veterinarians Use OCT to Evaluate Eye Health, Cancer Margins, and Joint Strength
Medical doctors have long understood the value of optical coherence tomography (OCT) for monitoring human health. Veterinarians are learning that the technology can be just as vital in evaluating the well-being of patients in the animal kingdom....
BioPhotonics, Nov/Dec 2020
Inaugural Photonics Spectra Conference to Highlight Innovations in Lasers, Optics, More
The first Photonics Spectra Conference is set for Jan. 19-22, featuring presentations in four tracks: lasers, optics, biomedical imaging, and spectroscopy. Each day-long program will feature a keynote address and sessions that highlight the latest...
Photonics Spectra, December 2020
Angiographic OCT Images Forewarn of Disorders Caused by Maternal Drug Use
No amount of alcohol is considered safe during pregnancy, according to published research1. Despite this message being the subject of constant public service warnings, in a recent study, 20% to 30% of women in the U.S. reported drinking during...
BioPhotonics, Nov/Dec 2020
OCT Informs Real-Time Cancer Diagnosis
The origins of optical coherence tomography (OCT), a subsurface imaging technology based on low- coherence interferometry, can be traced to the first decade of the 1800s, when Thomas Young’s double-slit interference experiment showed that light...
BioPhotonics, Nov/Dec 2020
Superresolution Microscopy Analysis Accelerated by Machine Learning
Superresolution optical microscopy — a technology that enables the acquisition of fluorescent micrographs of samples with a resolution well below the optical diffraction limit of ~250 nm — is rapidly evolving. Several methods have been developed...
BioPhotonics, Mar/Apr 2021
Laser Direct IR Imaging Projects Microplastics Analysis
Contamination of soil, air, and drinking water by microplastics is a growing focus of attention around the world. Environmental agencies are increasing the monitoring of waterways, and governmental bodies are seeking to protect these resources....
BioPhotonics, Sep/Oct 2020
Raman Imaging Opens View to Diagnosis and Discovery
By revealing the chemical composition of samples, Raman microscopy has proved to be useful in many fields, including medical diagnosis, materials science, cosmetics, and food science. For the researcher, clinician, or engineer, it is most useful...
BioPhotonics, Sep/Oct 2020
3D Thermophotonic Imaging Informs Biomedicine
Imaging plays an important role in disease prevention, diagnosis, and treatment, and new technologies are helping to overcome many limitations to resolution and depth. Early diagnosis of diseases can alter the path of treatment and its efficiency...
BioPhotonics, Sep/Oct 2020
Portable Microscopy Leverages Advancements in Electronics and Computing
Spurred by Moore’s law, the principle that the number of transistors on a microchip doubles every two years, the miniaturization of electronic components has resulted in optical devices shrinking as well. While etendue (a characteristic of light and...
BioPhotonics, Sep/Oct 2020
Achieving Improved Signal-to-Noise Ratio in Flow Cytometry
Flow cytometry explores, analyzes, counts, and sorts small particles. With the increasing demands for higher data quality from researchers, clinicians, and manufacturers, component builders for these systems are being driven to increase the...
BioPhotonics, Jul/Aug 2020
Microscopic Methods Reveal Holistic Picture of Sample
Whole slide imaging is a method principally employed when scientists need to image a large, relatively two-dimensional sample that expands beyond a single microscope field of view. Typical applications include imaging of histological tissues that...
BioPhotonics, Jul/Aug 2020
Diffuser Modulation Enables Quantitative Lensless Microscopy
Traditional optical microscopes require constant adjustments to bring a sample into focus. To see a small feature with details, researchers must use a high-resolution objective lens with a reduced field of view. The trade-off between resolution and...
BioPhotonics, Jul/Aug 2020
Quantum Dots Put Focus on Neuronal Imaging
Despite increasing efforts to solve the puzzle that is the workings of the human brain, scientists’ current understanding of the brain’s functional interconnections remains limited. As the most complex organ in the human body, the brain...
BioPhotonics, Jul/Aug 2020
Diffuse Optics Filters Diagnoses
Diffuse optics and the study of light absorption and scattering in various tissues can track blood oxygenation and other factors that help assemble an accurate medical diagnosis. Light scatters multiple times when traveling through a thick tissue...
BioPhotonics, May/Jun 2020
Light Brings a Delicate Touch to Treatment
Almost as soon as the first working laser was built in 1960 by Theodore Maiman, reports from users of lasers multiplied regarding the curious effects that light can elicit on living tissue. In 1962, dermatologic surgeon Leon Goldman reported the...
BioPhotonics, May/Jun 2020
Light Sheet Microscopy: Transforming 3D Fluorescence Imaging
Light sheet fluorescence microscopy (LSFM) is a fast and efficient imaging technique that combines the speed of wide-field imaging with optical sectioning and low photobleaching. LSFM has become an important fluorescence imaging modality, especially...
BioPhotonics, May/Jun 2020
NIR-II Looks Deep into the Research Realm
In vivo imaging in the second near- infrared biological window (NIR-II) is in its early stages but will undoubtedly affect life science research on many levels, both in preclinical and clinical work and in universities and medicine. Research in...
BioPhotonics, May/Jun 2020
Opsins Travel to the Brain’s Hidden Places
The brain is one of the most complex systems in the known universe, a living computer that controls not only basic functions of the body but ponders and directs responses to what’s going on in its surroundings. But when it comes to...
BioPhotonics, Mar/Apr 2020
Spectroscopic Technique Targets Drug Porosity
In the pharmaceutical field, porosity is an important trait in helping to measure the effectiveness of tablet quality. Thanks to modern spectroscopic techniques, manufacturers are getting the characteristics they’re looking for. Porosity, in...
BioPhotonics, Mar/Apr 2020
A Laser Points Toward Disease Diagnosis
According to the latest reports from the United Nations Department of Economic and Social Affairs and the World Health Organization (WHO), life expectancy has more than doubled in the last two centuries, from less than 30 years to over 70, thanks to...
BioPhotonics, Mar/Apr 2020
The Microscope Enters the Digital Age
Within the field of pathology, the upright light microscope is perhaps the most ubiquitous piece of equipment used for examination. Found on every pathologist’s desk, the glass and light device plays a central role in disease diagnosis, displaying...
BioPhotonics, Mar/Apr 2020
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