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Features
Flexible Image Analysis
Historically, biology researchers examined samples predominantly by eye, but now digital capture of images is commonplace, and objective quantification of those images using automatic analysis software is increasingly desirable. Analyzing images one by one (for example, with Adobe Photoshop) can be tedious and subjective. Fully automated image analysis is not only more objective, but it also allows thousands of images to be analyzed. We created CellProfiler to meet the need for flexible,...
BioPhotonics, July 2007
High-Content-Screen Microscopy Enables Large-Scale Multiplex Image Analysis
Quantitative analysis of cellular images is critical for investigating neuronal function and disease mechanisms in modern neuroscience drug discovery research. In the study of Alzheimer’s disease, neurotoxicity of β-amyloid peptide 1-42...
BioPhotonics, July 2007
Holmium:YAG Laser in Clinical Urology
The holmium:YAG laser is widely used in urologic surgery. The solid-state laser is available in variable power configurations from 10 to 100 W and is released in a pulsed-mode system, allowing high-energy delivery to tissue while limiting the amount...
BioPhotonics, July 2007
Medical Laser Market on the Rise
Minimally invasive laser surgery is growing in use and is preferred for many procedures because lasers can reach areas where access is difficult with traditional surgical methods. The technique involves practically no incisions, and healing is much...
BioPhotonics, July 2007
Nanotechnology for Biology: Exploring Cellular Activity and Abnormality
Nanotechnology is becoming increasingly popular in the medical field, both in imaging and in direct treatment applications. The risks associated with nanotechnology are prompting researchers and scientists to develop safe ways to investigate...
BioPhotonics, July 2007
Spotting Prostate Cancer Automatically
Prostate cancer, according to the American Cancer Society, is among the most common malignancies in men and is the second leading cause of death, accounting for about 10 percent of male cancer-related mortality. If the disease is caught early, the...
BioPhotonics, July 2007
Fiber Coating for Medical Devices
Silica optical fibers have a long history of delivering laser energy in surgical, aesthetic, dental and sensing medical applications. Today’s lasers use higher power levels in lithotripsy (the procedure that breaks up kidney stones), benign...
BioPhotonics, June 2007
Laser Incision of Urethral Strictures
Urethral stricture disease, characterized by a narrowing of the urethra, may develop after trauma, indwelling catheterization, endoscopic urological procedures or radical prostatectomy surgery for prostate cancer. Those with stricture disease may...
BioPhotonics, June 2007
New and Improved Fluorescent Proteins
As with the microscopes and detectors that measure their emissions, fluorescent proteins are constantly being improved. Three recent projects promise a new spatially confined imaging method, offer more reliability in what has been a mistrusted...
BioPhotonics, June 2007
Thinking Small
Research in biotechnology and biopharmaceuticals can be a daunting process, involving costly reagents, complex interactions and time-consuming analysis. Fortunately, an emerging family of technologies promises to cut some of those expenses,...
BioPhotonics, June 2007
Understanding Ancient Life
Photonic techniques are helping researchers dig deeper than ever into the past, unearthing new findings about some of the oldest — as well as some of the largest — skeletonized organisms known in the geological record. Raman spectroscopy and...
BioPhotonics, June 2007
Yellow Lasers Target Macular Degeneration
Age-related macular degeneration (AMD) is a leading cause of blindness and diminished eyesight and is associated with bleeding in the retina. There are two recognized forms of AMD: wet and dry. The wet form is characterized by abnormal growth of...
BioPhotonics, June 2007
Better Fluorescent Probes Facilitate Cellular Imaging
Fluorescent probes are small but powerful, shedding light on the inner working of cells and the diseases that afflict them. However, sometimes the right probe for a particular job does not exist. That is why research and development of new probes...
BioPhotonics, May 2007
Medical Lighting
The state-of-the-art surgical suite is a streamlined center where efficient work flow is key. Fluoroscopes, ultrasound units, electrocauteries, cutting devices, video cameras, robots and more are positioned where needed and pushed out of the way...
BioPhotonics, May 2007
Microtomy with Femtosecond Lasers
A microtome is an instrument used to prepare thin sections of human, animal or plant tissue for microscopic examination. Usually, sectioning biological specimens is performed by microtomes that work mechanically. These instruments require that...
BioPhotonics, May 2007
A Fluorescent Phantom for Small-Animal Imaging
Small animals represent vital model systems for the study of organism development and human disease. They are increasingly recognized as powerful discovery tools in genetic, proteomic and cancer research. For example, animal studies have vast...
BioPhotonics, April 2007
Controlled Light Exposure Microscopy for Confocal Imaging
Fluorescence imaging of live cells and tissues is a powerful technique that is increasingly finding new applications in the biological sciences.1 However, photobleaching and phototoxicity can present significant challenges for many types of...
BioPhotonics, April 2007
Taking It to the Streets with SPR
Surface plasmon resonance (SPR) — a label-free technique for measuring biomolecular interactions in real time — benefits a wide variety of applications, from basic science to drug discovery. The technique monitors the refractive index of materials...
BioPhotonics, April 2007
LEDs Have a Bright Future in Biomedical Instruments
Bright but not yet brilliant might be the best way to describe LEDs as they are used in biomedical instruments and research applications. The advent of high-brightness LEDs that produce light across the visible and ultraviolet spectra, along with...
BioPhotonics, March 2007
Measuring Colocalization within Fluorescence Microscopy Images
Intermolecular interactions between receptors and small ligands, nucleic acids and proteins, as well as between various proteins, are tightly regulated within cells as the molecular-level mechanism that controls almost all biochemical processes —...
BioPhotonics, March 2007
Probes Light the Way for Advances in FRET
First described almost 60 years ago, Förster resonance energy transfer (FRET) traditionally uses two molecules — donor and acceptor — to visualize biological activity. Today the technique continues to evolve. In FRET, if molecules are close...
BioPhotonics, February 2007
Ultrafast, Ultrawide-Band Spectroscopy
The interdisciplinary study of molecular science aims to expand our knowledge of everything around us, from the molecular bonds that give plastic widgets their strength to the electron transitions that power microprocessors, lasers and society as a...
BioPhotonics, February 2007
Adaptive Optics Under the Microscope
Originally developed to see the very large and far away, adaptive optics is now being used to see the very small and relatively near. Astronomers perform a technique that rapidly adjusts optical elements, typically mirrors, to remove the twinkle...
BioPhotonics, January 2007
Detection Systems Reduce Collisions with Wildlife on Rural Highways
As vehicular traffic increases, so do animal-vehicle collisions. Detection systems that sense when an animal may be near the road are installed in a few US states and at several locations in Europe to warn motorists to exercise caution. The...
BioPhotonics, January 2007
Molecular Imaging via MRI
When it comes to peering inside the body, MRI offers some significant advantages over other imaging techniques. It is noninvasive and rapid, does not involve potentially damaging ionizing radiation, and can spot problems deep within tissue. That is...
BioPhotonics, January 2007
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