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Fluorescence Imaging Enters the Surgical Suite
In the last decade, researchers have worked extensively on medical devices and applications that measure the spectral response of tissue to various wavelengths of light. These applications, in a lab or proof-of-principle setup, have proven the usefulness of spectral imaging to strengthen diagnosis by uncovering information hidden in the spectral signature. Studies have proven that spectral signatures can distinguish between healthy and cancerous tissues.
BioPhotonics, May/Jun 2017
Medical Lasers Cut and Heal
For medical lasers, the future may include both addition and subtraction. That’s because in medicine, lasers have traditionally been used for ablation, cutting and other processes that remove tissue. Now researchers and companies are looking...
BioPhotonics, May/Jun 2017
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FLIM Delivers Intracellular Images Based on Differences
Fluorescence lifetime imaging microscopy (FLIM) enables researchers in the life sciences to get information from live specimens about interactions on the molecular scale. The technique captures the differences in the excited state decay rate from a...
BioPhotonics, May/Jun 2017
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Challenges and Opportunities in Superresolution
Much of our understanding of biology has come from our ability to image biological processes and structures through microscopes. But until recently, the imaging of intracellular structures and activities has been constrained by the optical...
BioPhotonics, May/Jun 2017
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Point-of-Care Photonics Deliver Vital Care in Developing Regions
Nowhere does the burden of disease weigh as heavily on people as it does in the low-resource settings of the developing world. Residents in parts of Asia, Africa and South America are highly vulnerable to communicable diseases such as malaria and...
BioPhotonics, April 2017
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In Optogenetics, Femtosecond Lasers Blaze New Paths
One of the most active and exciting areas in neuroscience is the use of optogenetics to unravel how neural pathways in the brain process and transmit information. Optogenetics involves the use of light-sensitive opsins — a special class of...
BioPhotonics, April 2017
Advances in Surgical Microscopes Pave the Way to Improved Outcomes
By integrating intelligence, video, intraoperative-imaging and navigation technologies, today’s surgical microscopes provide surgeons with insights to improve their decision-making at the point of care and provide patients with the best...
BioPhotonics, April 2017
Probing Cancer by Exploiting Spontaneous and Stimulated Raman Scattering
Most of our knowledge about the chemical contents in cancer cells or cancerous tissue is obtained from in vitro analysis of fixed cells and tissues or homogenates. These in vitro assays identify the presence of molecules, but do not provide...
BioPhotonics, April 2017
Modular Accessories Expand Fluorescence Microscope Capabilities
Despite the superior spatial resolution of complementary newer technologies such as atomic force microscopy (AFM), fluorescence microscopy remains a preeminent technology in the life sciences. Fluorescence detection offers a uniquely simple method...
BioPhotonics, January 2017
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Where Does OCT Go From Here?
OCT-A — optical coherence tomography angioplasty — which allows imaging without dye, is a promising breakthrough in the detection of early-stage glaucoma. And swept-source OCT has opened new possibilities for diagnosing diabetic retinopathy and...
BioPhotonics, Feb/Mar 2017
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Managing Heat in Biomedical Devices
Biophotonic devices, packages and systems are subject to performance variability and failures at high temperatures because of thermomechanical stresses and corrosive decay. But optical performance depends on consistent behavior of materials and...
BioPhotonics, Feb/Mar 2017
Photobiomodulation Therapy Comes of Age
Important advances in our understanding of the basic science of photobiomodulation are influencing the development of laser technology and the use of these devices to treat a number of diseases and injuries.
BioPhotonics, Feb/Mar 2017
Near-Infrared Spectroscopy Probes Food Freshness
Near-infrared (NIR) spectroscopy is well-suited to analysis of bulk, high-moisture agricultural samples such as fruit, grains, fish and meat. Light at NIR wavelengths penetrates samples with less scattering than other techniques, allowing internal...
BioPhotonics, Feb/Mar 2017
Breaking the Speed Barrier for High-Fidelity, Large-Area Confocal Scanning
The need to image microstructures over very large areas is driving the next generation of instrumentation in microscopy. The challenge is complex: How can very large areas be scanned quickly and with high fidelity? Conventional wide-field...
BioPhotonics, January 2017
Optical Fibers Illuminate Brain Activity
Medical imaging faces inherent limitations depending on its presentation mode. Computer models and virtual reality, while much more effective than two-dimensional depictions, are nonetheless images on a computer screen. Even with the use of...
BioPhotonics, January 2017
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Smartphones Poised to Shake Up Spectroscopy
This June will mark the 10-year anniversary of the release of Apple’s iPhone. It did not take long for this mobile operating system to earn its reputation as a disruptive innovation, with that disruption being most palpable in the digital-camera...
BioPhotonics, January 2017
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Facial Lasers’ Future: Shorter Downtimes, Darker Skin Types
When Dr. Mark Schwartz started performing laser facial rejuvenation treatments, he had regularly advised his patients that they should expect a month of downtime, meaning they’d experience redness, crustiness and swelling from the full-field,...
BioPhotonics, December 2016
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Ultralow-Light CMOS Bio-Optical Sensor Enables Low-Cost, Portable Molecular Testing
The miniaturization of molecular tests enabled by CMOS biosensors and microfluidics could have positive impacts on global efforts against infectious diseases and cancer.
BioPhotonics, December 2016
Fluorescence Correlation Spectroscopy — Going Beyond the Diffraction Limit
The combination of short measurement times along with free position or scanning of the observation spot makes fluorescence correlation spectroscopy an excellent tool for investigating diffusion heterogeneity over time and space.
BioPhotonics, December 2016
Hyperspectral Microscopy: A Powerful Technique for Multiplexed Imaging
The field of biomedical imaging represents the acquisition of images for diagnosis and treatment evaluation using various imaging techniques, such as MRI, ultrasound, x-ray, PET and more. In the past few years, nondestructive techniques based on...
BioPhotonics, December 2016
Swept Source OCT Takes Optical Medical Imaging to the Next Level
Swept source optical coherence tomography enables much faster imaging for comprehensive wide-field, 4D screening of large organs or dynamic processes.
BioPhotonics, October 2016
Member Exclusive
LEDs and Lasers Battle for Dominance in Brain Research
Lighting up the brain to better understand, treat or even cure brain disorders has become an established field known as optogenetics. First introduced in 2005 by professor Karl Deisseroth as he worked in a small laboratory at Stanford University, it...
BioPhotonics, October 2016
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Nonlinear Microscopy Moves Into the Operating Room
The quality of a person’s vision can influence life-and-death situations, and this is especially true for a surgeon cutting with the scalpel. Consequently, over the years, researchers have developed several techniques to improve and enhance...
BioPhotonics, October 2016
Near-Infrared Spectroscopy: Delving Deeper in the Brain
As a functional brain monitoring and imaging technique, functional near-infrared spectroscopy (NIRS) has undergone a tremendous transformation. Over the past two decades, the technology has grown from bulky prototype instruments measuring one or two...
BioPhotonics, October 2016
Live-Cell Imaging Thrives With Microenvironment Control Systems
As microscopy techniques become more complex and require researchers to keep specimens under objectives for longer periods, microenvironmental control systems play an important role in pushing the limits of live-cell imaging.
BioPhotonics, September 2016
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