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Fluorescence News
Affordable Light-Sheet Microscope Could Spur Biomedical Exploration
TOKYO, July 22, 2024 — By broadening the availability of light-sheet fluorescence microscopy (LSFM) world-wide, a team at Juntendo University is helping to smooth the path to future discoveries in biomedicine. Advancements in tissue clearing techniques have made LSFM systems an important tool for biomedical research. However, the complexity and high cost of these systems have put them out of the reach of many end-users in the biomedical field. Greater accessibility to tissue clearing techniques could help
STED Microscopy Uncovers Signals Between Molecules
Jul 7, 2024 — Stimulation emission depletion (STED) microscopy is a mainstay in superresolution imaging, since scientists established its capability to drastically improve the lateral resolution present in traditional fluorescence microscopy. In recent years, it...
Optofluidic Antenna Enhances Single-Molecule Sensitivity in Liquid
ERLANGEN, Germany, May 13, 2024 — Single-emitter fluorescence detection is used in diverse fields, from biophysics to quantum optics, to precisely observe processes at the single-molecule level. When performed under fluidic conditions, diffusion restricts the observation time and...
Double-Clad Fiber Couplers Enhance Multimodal OCT Results
May 5, 2024 — Recent research efforts have aimed to enhance OCT’s information content by combining it with imaging modalities exploiting complementary optical contrasts. The design of optical coherence tomography (OCT) systems has evolved significantly in...
Microprism-Mediated Calcium Imaging Reveals Neural Dynamics Over Time
SEATTLE, April 10, 2024 — An approach to deep brain imaging developed at the University of Washington uses microprisms to provide stable tracking of neuronal activity over a large field of view. According to the research team, the microprism technique is a significant...
Making the Photon Count in Confocal Microscopy
Mar 14, 2024 — When used appropriately, a laser scanning confocal fluorescence microscope is a valuable tool for researchers to make quantitative measurements in cells and tissue across various life sciences applications. The laser scanning confocal...
Memory Element Enhances a Human Sight-Mimicking Quantum System
HONG KONG, March 11, 2024 — Collaborating researchers from Hong Kong, China, and Germany have developed a quantum-sensing technology that encodes changes in fluorescence intensity into spikes that occur during optically detected magnetic resonance (ODMR) measurements. The...
SPAD Elevates Spatiotemporal Resolution in Conventional Microscopes
GENOA, Italy, Feb. 23, 2024 — Image scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides better signal-to-noise ratio (SNR), optical sectioning, and spatial resolution better than that of a traditional...
Bruker Makes Fourth and Fifth Acquisitions of 2024
BILLERICA, Mass., Feb. 7, 2024 — In separate transactions, Bruker has acquired preclinical in-vivo optical imaging systems company Spectral Instruments Imaging (SII), and Nanophoton Corporation, a provider of advanced research Raman microscopy systems. Financial terms of the...
High-Throughput Imaging Reveals Multi-Particle Cellular Activity
BONN, Germany, Feb. 5, 2024 — A new software program can map the movements of multiple particles within cells simultaneously, providing insight into cellular functions that are difficult — and sometimes impossible — to investigate using single-cell tracking methods....
Stimulated Raman Photothermal Microscopy Provides Ultrahigh Sensitivity
Jan 16, 2024 — Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing molecular structures, dynamics, and couplings in complex systems. Yet, the sensitivity of SRS is fundamentally limited to millimolar level due to the shot noise...
Targeted Spectroscopy Can Improve Treatment of Eye Disease
EDMONTON, Canada, Jan. 5, 2024 — A targeted spectroscopy system developed at Zilia Inc., by a team led by professor Dominic Sauvageau from the University of Alberta, enables concurrent imaging of the eye fundus — a region at the back of the eye — and analysis of...
Algorithm Boosts Live-Cell Imaging's Capabilities
OEIRAS, Portugal, Nov. 27, 2023 — Superresolution radial fluctuations (SRRF), a superresolution algorithm, works by observing fluctuations in radial symmetry throughout the frames of an image. SRRF supports live-cell, superresolution microscopy on a range of microscopy platforms...
Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport
DAEJEON, South Korea, Nov. 22, 2023 — Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of photobleaching and the visual isolation of cellular...
Lasers Improve Phototherapy-Drug Delivery Platform
BALTIMORE, Nov. 7, 2023 — Photoimmunotherapy targets cancer cells with microscopic, nano-engineered cancer drugs that are light-activated at the lesion site. Although the technology is increasingly used to treat metastatic cancer, tools to improve the effectiveness of...
Live-Cell Imaging Follows Early Signs of Mutation and Disease
Nov 3, 2023 — Scientists are increasingly turning to live-cell imaging to track changes at the developmental stage of life, which is vital for the advancement of cellular biology, and to grow and monitor proliferating stem cells and cancer cells in a contained...
Single-Cell Analysis Optofluidics Tool Delivers on Demand
QINGDAO, China, Sept. 20, 2023 — An on-demand optical system for exporting target droplets from a static droplet array (SDA) provides a simple way to export specific cells or analytes for analysis without compromising efficiency or accuracy. Researchers at the Qingdao Institute of...
Fiber Optic Probes Help Customize Spectroscopic Diagnosis
Sep 3, 2023 — Diffuse reflection spectroscopy and fluorescence spectroscopy are having a major effect in medicine and the life sciences, with expanding application in physics, chemistry, biology, and medicine. And fiber optic-based probes are becoming an...
Illumination Advancing Fluorescence Microscopy in Life Sciences, Medical Realms
Sep 3, 2023 — In many academic research and medical settings, microscopy and imaging have transitioned from using traditional lamp illumination, such as mercury and Xenon lamphouses, to solid-state LED technologies. The benefits of moving to LEDs include long...
Three Questions with Holger Schmidt
Sep 3, 2023 — Holger Schmidt, Ph.D., distinguished professor of electrical and computer engineering and the Narinder Singh Kapany chair of optoelectronics in the Baskin School of Engineering at UC Santa Cruz, discusses the application of signal processing...
Light-Activated Metal Particles Deliver Targeted Cancer Treatment
NOMI, Japan, Aug. 15, 2023 — A research group from Japan Advanced Institute of Science and Technology (JAIST) developed light-activatable, liquid metal (LM) nanoparticles for cancer diagnosis and treatment via photoimmunotherapy. The LM nanoparticles can target and destroy...
Near-IR Biosensors Use DNA Anchors to Target Range of Molecules
BOCHUM, Germany, Aug. 10, 2023 — To build a flexible sensor for optically detecting a range of viruses and bacteria, a group of researchers from Ruhr University Bochum (RUB), the Fraunhofer Institute for Microelectronic Circuits and Systems (IMS), and ETH Zurich used...
Optical Measurements Combine for Early Metastasis Detection
BOSTON, Aug. 10, 2023 — Diffuse in vivo flow cytometry (DiFC), an optical technique developed at Northeastern University, enables fluorescence detection of tumor cells circulating in the bloodstream. It is a promising technique for detecting cancer that has metastasized....
Fluorescence Polarization Approach Allows Quantitative Cancer Diagnosis
Jul 3, 2023 — Fluorescence polarization (Fpol) is an optical phenomenon that characterizes the polarization of fluorescence emissions relative to the polarization state of the excitation light. It is sensitive to factors that influence the rotational motion of...
Precision Positioning Aids Microscopes with Tracking Viral Progression
Jul 3, 2023 — The rapid spread of COVID-19 and other diseases has shown that understanding viral infection is critical to the health of people around the world. In particular, understanding the dynamics of the earliest stages of infection is important for...
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Jul/Aug 2024
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Objective Specifications Drive Performance in Biomedical and Life Sciences Research
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