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Detecting Colon Cancer, Virtually
For scientists researching ways to prevent death, colon cancer offers a tempting target because screening techniques can spot precancerous tissue, and it is known which part of the population should be checked. And even though benign lesions (known as adenomas) may take up to a decade to become dangerous, there are methods to safely remove them. A 3-D endoluminal view of a sigmoid villous adenoma is seen in a 60-year-old female undergoing screening via computed tomography colonography....
BioPhotonics, March 2008
Hyperspectral Imaging for the Life Sciences
Multispectral and hyperspectral imaging techniques were developed for applications in remote sensing and astronomy but have slowly transitioned into use in many areas of the life sciences, including fluorescence microscopy and in vivo imaging....
BioPhotonics, March 2008
The Quest for a Better Biological Imaging System
Imaging biological systems on the cellular and even molecular level requires a material that is as versatile as it is durable. Quantum dots possess many of the attributes necessary for this purpose. The strengths of these nanosize semiconductors...
BioPhotonics, March 2008
LEDs for Fluorescence Microscopy
Until recently, fluorophore excitation has been achieved using broad-spectrum mercury gas discharge lamps with a combination of optical filters to remove many of the unwanted wavelengths. These lamps are widely used and accepted in microscopy...
BioPhotonics, February 2008
New Developments in SPR Biosensing
Surface plasmon resonance (SPR) biosensors have been developed for a variety of applications, from early diagnosis of disease to drug discovery and from water purity analysis to identification of pathogens possibly used for bioterrorism. Offering...
BioPhotonics, February 2008
Raman Analysis Speeds into Biomedicine
Raman is one of a number of spectrographic techniques that may be used to study biological materials. Of these, dispersive Raman imaging offers a compelling range of capabilities, providing superior chemical specificity with excellent spatial...
BioPhotonics, February 2008
CMOS Cameras Enter the Life Sciences Market
When a rat decides on a course of action, you can’t ask it what factors played a role in that decision. But Jason Ritt, a postdoctoral fellow at the McGovern Institute for Brain Research at MIT in Cambridge, Mass., had to get as close as possible to...
BioPhotonics, January 2008
Fiber Optics and MEMS
During the past 16 years, nonlinear optical microscopy has evolved from a photonic novelty to a well-established laboratory tool. Rapid development of fiber optic components with growing functionalities and decreasing size provides enormous...
BioPhotonics, January 2008
Fiber Optics in Surgery
One of the vital steps of most surgical procedures is bonding the edges of human tissue. Surgeons use sutures, staples or adhesives to close incisions in tissue, which encourages natural wound healing processes. An alternative method, which has been...
BioPhotonics, January 2008
Highly Stable UV Fiber
Raman spectroscopy with in situ UV optical fiber probes, UV confocal laser scanning microscopy using optical fiber-laser coupling, and UV fiber optic spectroscopy for gas chromatography are just a few of the applications using optical fiber as a...
BioPhotonics, January 2008
Rare-Earth Doped Nanocrystals for Biosensing and Imaging
There has been a great deal of interest in the fabrication and characterization of highly luminescent nanoparticles because of their potential applications as nanosensors and as biosensors for applications such as molecular diagnostics. The organic...
BioPhotonics, January 2008
The New x in FTTx
The term FTTx is shorthand for fiber to the x, with the x being a particular destination, such as the desk or the home. This term is taking on new meaning as optical fiber has extended into many new and challenging medical and surgical applications....
BioPhotonics, January 2008
Thulium Fiber Lasers
The use of lasers as medical instruments has increased dramatically in recent years because of the growing acceptance and efficacy of laser procedures as an alternative to traditional surgeries. A recent market report by Frost & Sullivan, a...
BioPhotonics, January 2008
AFM Reveals Biological Mechanisms
Some of the latest atomic force microscopy (AFM) research demonstrates that the technique can provide information about the molecular composition of protein complexes and can show how something as tiny as a retrovirus, such as HIV, replicates in...
BioPhotonics, December 2007
Clipped to a Shark’s Fin, Collared to a Bear or Attached to a Crow’s Tail, Wildlife Cameras Come of Age
When the finishing touches were put on the first Crittercam 20 years ago, the device more or less resembled a camera. It did take pictures, and it was attached successfully to a loggerhead sea turtle. But those early models — 2 ft long, weighing...
BioPhotonics, December 2007
LEDs for Bioanalytical and Medical Instruments
The much-anticipated availability of LEDs for applications in biophotonics finally is manifesting itself in a new selection of more efficient, longer-lived illumination products. LEDs have long held promise as a simple, low-cost alternative to...
BioPhotonics, December 2007
New Directions in FRET
Förster resonance energy transfer (FRET) continues to provide researchers with a means to quantify protein-protein interactions and other molecular dynamics by labeling molecules with a donor and an acceptor, which give off a characteristic emission...
BioPhotonics, December 2007
A Brighter Red, a Simpler Green and Structural Understanding
Fluorescent proteins are essential tools for probing and understanding biochemical processes as they happen. And as any mechanic or handyman knows, you have to have the right tool for the job. That is why research into the development of new...
BioPhotonics, November 2007
Engineer-Physician Collaboration Model Aids Biophotonics in Medicine
The direct application of engineering to medicine is a notable trend of the past decade. Noninvasive diagnostic technologies, high-resolution imaging, advanced materials implants and controlled-release drug delivery systems are just a few examples...
BioPhotonics, November 2007
OCT Could Enable Noninvasive Diabetes Monitoring
The majority of diabetes patients must prick themselves several times a day to monitor their glucose level. They then self-administer insulin or medication to ensure that their level remains within the appropriate range. Several light-based...
BioPhotonics, November 2007
OCT Imaging for Cochlear Surgery
Cochlear implants are used to stimulate directly the nerve structures in patients with nonfunctional receptor cells. Such electrodes traditionally have been used only in deaf patients, but recently these devices have been implanted in patients with...
BioPhotonics, November 2007
Optical Coherence Tomography Aids Cancer Detection
Optical coherence tomography (OCT) has been applied successfully in ophthalmology since the early 1990s, a success story triggering research efforts in the imaging of early epithelial cancers. Typical nonophthalmic systems achieve a resolution of 10...
BioPhotonics, November 2007
Advances in Multiphoton Microscopy
A look at some of the latest work in multiphoton microscopy shows that advances in the technique are enabling new images and research, including uncovering the workings of muscle and the growth of bone. Other advances in technology show that,...
BioPhotonics, October 2007
Dental X-Ray Imaging Goes Digital
Recent advances in digital radiographic imaging technology are changing the practice of dentistry. Digital panoramic and intraoral imaging provide instant access to adjustable high-quality images with a lower radiation dosage than that required for...
BioPhotonics, October 2007
Early Cancer Detection with Fluorophores That Target the Folate Receptor
All it takes is one tumor cell circulating through the bloodstream to turn a manageable tumor into metastatic disease, and just one tumor cell can cause cancer to recur in patients who have received treatment. Although high-resolution clinical...
BioPhotonics, October 2007
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