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BioPhotonics - April 2018


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Features
Multiphoton Microscopy Sets the Standard for Live-Cell Imaging Multiphoton imaging is widely used for live-cell imaging. Many of the applications are in neuroscience, where the overarching trends involve deeper imaging using longer wavelengths. These trends are...
Vying for Dominance: Swept-Source vs. Spectral-Domain OCT Optical coherence tomography (OCT) is among the most widely used in vivo optical diagnostic techniques. This high-resolution 3D imaging modality, with market size approaching $1 billion, has...
Remote Noninvasive Sensor Monitors Multiple Bioparameters Photonic-based sensing is an evolving field that provides a large variety of possible biomedical applications for home care diagnosis. Various aspects of light and photons can grant us the ability to...
Member Exclusive
SMS Reveals Hidden Behaviors It was 28 years ago that the first optical experiments to detect a single molecule took place in the Moerner Laboratory at IBM Research, with relatively esoteric, low-temperature, high-resolution...
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Editorial
Equal to The Future The image created by label-free multimodal, multiphoton microscopy on the cover is part of one lab’s contribution to the development of a more accurate and faster means of conducting biopsies. This particular image comes from the Biophotonics Imaging Laboratory at the University of Illinois at Urbana-Champaign. But, writes laboratory head Stephen Boppart in this month’s Biopinion, the...
BioScan
Microscope Provides Precise 3D Imaging of Thick Mammalian Cells A new microscope produces 3D nanoscale images of mammalian cells in their entirety. Because the axial positions of the single emitters are encoded in the shape of each single-molecule image rather...
Nanophotonic Sensors Monitor Processes in Living Cells A large-scale biosensor developed using nanoplasmonic material is able to accommodate a large number of cells on a single substrate and monitor cell proliferation in real time. The nanoplasmonic...
Nanocarbon Shows Promise for Fluorescent Bioimaging An international team from Nagoya University and Boston College has developed a flexible, water-soluble warped nanographene molecule that is biocompatible. The molecule was also found to induce cell...
Spectroscopy Explores Photoinduced Reactions in Anticancer Drug Using IR spectroscopy researchers have gained fresh insight into how a platinum-based chemotherapy drug candidate functions when activated by light. Completely inactive and non-toxic in the dark, the...
Far-UVC Light Could Safely Limit Spread of Flu, Other Airborne Viruses Continuous low doses of far-UVC light have been shown to kill airborne flu viruses without harming human tissue. Far-UVC light could offer a low-cost solution to controlling airborne microbial...
F-VLEDs Reduce Heat Generation, Opening Way for Biomedical Applications Flexible vertical micro-LEDs (f-VLEDs) have been developed using anisotropic conductive film (ACF)-based transfer and interconnection technology. Thermal reliability and lifetime was improved by...
Phototherapy Treats Metastatic Disease Using Light-Sensitive Drugs A new study could expand the use of phototherapy for treating metastatic disease. Researchers have demonstrated the treatment of disseminated cancer by delivering photoactivatable drugs within...
Bright Light Therapy Improves Sleep in Cancer Patients Researchers investigated the effect of systematic light exposure on sleep in a mixed group of fatigued cancer survivors following primary cancer treatment. Results of the randomized controlled trial...
Microscopic 3D Printing Could Build Structures Inside the Body Researchers have used ultrathin optical fibers to create microscopic structures via laser-based 3D printing. The microstructures, which were created on a microscope slide, exhibited a 1.0-micron...
IR Thermal Imaging Improves Inspection of Radiation Shields Researchers at the Children’s National Health System have published a story in the Journal of the American College of Radiology detailing the use of IR thermal imaging as a tool to detect...
RapidScan
Rice Team Earns $10M NSF Award for Live Biology Microscopy The National Science Foundation (NSF) has awarded $10 million to a Rice University-led team that aims to create wearable and point-of-care microscopes that use on-chip illumination and sensing to...
Wang Wins Feld Biophotonics Award The Optical Society (OSA) has awarded Lihong Wang at the California Institute of Technology with the 2018 Michael S. Feld Biophotonics Award for inventing the world's fastest 2D receive-only camera...
Optalysys, EL Complete Genetic Project With Innovate UK Grant Optical artificial intelligence systems developer Optalysys Ltd. and genomic research institute the Earlham Institute (EI) have announced the successful completion of the Genetic Search System...
ISO Certifies II-VI for Biomedica Design, Assembly Engineered material and optoelectronic component developer II-VI Inc. has received ISO 13485 certification for its product development center in Dallas, Texas, to support the design and manufacture...
Jenoptik Opens California Facility Integrated photonics company Jenoptik AG has opened a new application center in Fremont, California. The new office will serve the engineering and product development needs of the region. Personnel...
Biolase Receives Accolades for 3 Dental Laser Systems Dental laser developer Biolase Inc. has received awards for three of its dental laser systems from leading industry organizations. The Waterlase iPlus picked up this year's Dentaltown Townie Choice...
RPI’s Sawyer, Tufts’ Koomson Receive Grant for Floodwater Research Rensselaer Polytechnic Institute Professor Shayla Sawyer and Tufts University Professor Valencia Koomson, both part of the Center for Lighting Enabled Systems and Applications (LESA), have been...
CU Researchers win BRAIN Initiative Grant for Miniature Microscope Researchers from the University of Colorado’s Anschutz Medical Campus and the University of Colorado Boulder have won a $2 million grant to refine their unique microscope while expanding its...
BioOpinion
Optical Biopsies Can Transform Pathology Histopathology has long been the gold standard for disease diagnosis. Many of the processes date back to the late 1800s. Immunohistochemistry (IHC) evolved in the late 1900s, providing a means to target molecular receptors and cell or tissue features that were more specific to molecular subtypes of disease. Despite the historical significance and reliance on H&E and IHC histopathology, the...
Postscripts
By Confining Light, Silk May Create Biosensors Nobel laureate Philip Anderson predicted that electrons can be brought to a complete halt in materials because of their scattering and defects. Named after the prize winner, the Anderson localization of light proposes that light waves can be confined in the same manner. Because the phenomenon requires extremely condensed and densely packed disordered nanostructures, it has been elusive and...
Products
Automated Microscope The LionHeart LX Automated Microscope from BioTek Instruments Inc. is an affordable and compact automated microscope offering contrast brightfield, color brightfield and fluorescence imaging with up to 100× air and oil immersion magnification. Users can automatically image microplates, slides, cell culture dishes and flasks with ease. Gen5 Microplate Reader and Imager Software...
BioTek Instruments Inc.
Fluorescence Microscopy Light Source The pE-4000 from CoolLED Ltd. is a fluorescence microscopy light source with updated LED technology. With sustainable green technology, the light source features a maximum power consumption of...
CoolLED Ltd.
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Drug Formulation Camera The FlowCam Nano from Fluid Imaging Technologies Inc. enables biopharmaceutical scientists to assess the colloidal stability of drug formulations to determine their resistance to aggregation over...
Yokogawa Fluid Imaging Technologies Inc.
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Multiline Laser The Cobolt Skyra multiline laser from Cobolt AB features up to four wavelengths permanently aligned in a single compact package and requires no external electronics. The Cobolt Skyra aims to...
Cobolt AB
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Femtosecond Fiber Lasers The Carmel X-series of femtosecond fiber lasers from Calmar Laser Inc. provide high power, ultrashort pulses, and high stability in a compact package for OEM, scientific and industrial applications....
Calmar Laser
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Focal Spot Analyzer MKS Instruments, a global provider of technologies that enable advanced processes and improve productivity, introduces the Ophir® Focal Spot Analyzer, a laser beam monitoring system that measures...
MKS Ophir, Light & Measurement
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Calibration Slide Developed with input from bright-field microscopy experts, the IAM-9C-SECCAL color transmission calibration slide from Applied Image Inc. offers NIST-traceable color integrity of digitally captured...
Applied Image Inc.
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Laser Head Series The QOMO laser head series from II-VI Inc. is designed for analytical instruments in the life sciences field including for flow cytometers, confocal microscopes and biomedical imaging applications....
Coherent Corp.
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Microspectrophotometer The 20/30 PV microspectrophotometer from Craic Technologies Inc. gives users the ability to collect UV-VIS-NIR absorbance, reflectance, fluorescence and Raman spectra of microscopic sample areas with...
CRAIC Technologies
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Polymer Nanoparticles Conjugated polymer nanoparticles (CPNs) from Stream Bio Ltd. have all the beneficial features of existing fluorescent markers while avoiding the use of heavy metals. A polymer-based, nontoxic...
Stream Bio Ltd.
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LED Light Source Module The RGB LED light source module from the Berliner Glas Group provides a high degree of light with small light guides. Up to 40 lm can be emitted from one fiber with a diameter of 0.7 mm. By...
Berliner Glas GmbH
Chemiluminescence Imaging Systems The GeneGnome XRQ chemiluminescence imaging system from Syngene is a dedicated chemiluminescence imaging system designed to rapidly and accurately image chemiluminescent Western blots. The blue...
Syngene USA
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Microscopy Imaging Solution The Imaris version 9.1 from Bitplane AG is a correlative microscopy solution that offers the ability to simultaneously visualize multiple 2D, 3D or 4D images with differing spatial or temporal...
Bitplane AG
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NIR Spectroradiometer The SR-6500 NIR spectroradiometer from Spectral Evolution Inc. features ultrahigh resolution and new high sensitivity levels with very stable performance with three thermoelectrically cooled...
Spectral Evolution Inc.
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Lab Enclosures EnviroMax Enclosures from Hemco Corp. are engineered to isolate lab automation instrumentation and processes that include liquid handling, powder weighing, sample weighing and high-throughput...
HEMCO Corp.
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Ventilated Laboratory Cabinet The GP540 from Asynt Ltd. is a bench-mounted, general-purpose, ventilated laboratory cabinet designed for use in a wide range of applications. The GP540 is optimized for applications such as...
Asynt Ltd.
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Cell Culture Dish The µ-Dish 35-mm Quad from Ibidi GmbH is a four-compartment cell culture dish that can be used for simultaneous assays, guaranteeing high optical quality. Researchers will benefit...
ibidi GmbH
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Handheld Spectrometers The PG100N line of high-precision handheld spectrometers from Gamma Scientific Inc. is well adapted for applications in horticulture, photography, general lighting, visual merchandising, health,...
Gamma Scientific
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Consultation Imaging The CytoXpress from Spot Imaging allows clinicians or technologists to transmit a live interactive image stream directly to a patient’s computer, eliminating the uncompensated travel and wait...
SPOT Imaging
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Neutron Imaging System Neutronic [i] from Photonis USA Inc. is a neutron imaging system that provides both high-resolution and high-detection efficiency when compared to traditional scintillator-based neutron imaging...
Photonis Technologies
Frequency Comb Quantum Cascade Laser Frequency Comb Quantum Cascade Lasers from Alpes Laser SA feature a spectrum that consists of a series of discrete, equally spaced frequency lines. Originally developed at optical wavelengths,...
Alpes Lasers SA
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Photovoltaic Atomic Force Microscopy Oxford Instruments Asylum Research Inc. has announced the Photovoltaic Option for the MFP-3D Infinity Atomic Force Microscope, expanding the device’s versatility. The Photovoltaic Option...
Oxford Instruments Asylum Research
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Spectrometry, Imaging Software Add-In McPherson Inc. has announced a new Add-In for Princeton Instruments’ 64-bit LightField software that controls McPherson’s deep UV and soft x-ray spectrometers and Princeton...
McPHERSON
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High-Resolution Imaging Spectrograph The SpectraPro HRS-500 high-resolution imaging spectrograph from Princeton Instruments features an astigmatism-corrected optical system for multichannel fiber applications. ResXtreme, spectral...
Teledyne Princeton Instruments
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VIS-NIR Coated Achromatic Lenses TECHSPEC VIS-NIR Coated Achromatic Lenses from Edmund Optics Inc. consist of two optical components cemented together to form a doublet and provide a low-cost alternative to air-spaced focusing...
Edmund Optics
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