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Zeiss Microscopy Technology Granted European Patent

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JENA, Germany, March 21, 2013 — Drs. Harald Hess and Eric Betzig of Carl Zeiss Microscopy have received a European patent for their superresolution photoactivated localization microscopy (PAL-M) technology. They received US patents in 2009 and 2011 based on the same invention. Patent EP 1894010 B1 protects methods and devices for PAL-M, which activates and excites only a small number of fluorescent dye molecules in a sample at a time. This enables the physical position of the individual fluorescent molecules to be determined to within a few nanometers. A superresolution image of the sample is generated by repeating a...Read full article

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    Published: March 2013
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    BiophotonicsBusinessCarl Zeiss MicrosocpyELYRA P.1 and PS.1Eric BetzigEuropeEuropean patentGermanyHarald HessImagingMicroscopyPAL-MPatent EP 1894010 B1superresolutionsuperresolution imagingUS patents

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