Seven early-stage startup companies have been selected to compete for a top prize of $10,000 at the 15th annual SPIE Startup Challenge at Photonics West on Jan. 28. The SPIE Startup Challenge is a competitive entrepreneurial platform for new businesses that utilize optics and photonics for innovative products or applications. Participating teams compete for sponsored prizes, in addition to gaining increased visibility with potential investors and exposure to potential collaborators or partners. Cash prizes of $10,000, $5,000, and $2,500, provided by Startup Challenge Founding Partner Jenoptik, will be awarded to the top three finalists. The SPIE Startup Challenge is also supported by lead sponsor Hamamatsu and supporting sponsor NextCorps Luminate. TRAQC was the winner of the 2024 SPIE Startup Challenge. (From left) Jenoptik’s Ralf Kuschnereit, TRAQC's Benjamin Dringoli, and 2024 SPIE President Jennifer Barton at the 2024 SPIE Startup Challenge. Courtesy of SPIE. Competition judges include venture capitalists and business-development experts from the photonics industry who will vet applicants for their business case, financial case, and competitive advantages. Teams competing in the Startup Challenge will get feedback on their business and pitch from business-development experts and investors. This year's products encompass innovations in medical applications, photovoltaic technology, and manufacturing. The seven 2025 SPIE Startup Challenge finalists and their technologies are: Atzeyo Biosensors, Inc.: Photonic Resonance Absorption Microscopy. The first molecular diagnostic platform for the physician’s office addressing cancer care. Max-IR Labs: AquaCarbon Monitor. Empowering carbon credits with precise CO2 monitoring in water systems. Photosynthetic B.V.: Volumetric Micro-Lithography. Enabling the rapid production of complex 3D devices with submicron features. OptiCardio: OptiCardio. A spectroscopy-enabled device for real-time guidance to reduce the recurrence rate of ablation procedures for atrial fibrillation. iSLight: Surface-Emitting SLED (Superluminescent LED). iSLight supplies superior lighting solutions to manufacturers of industrial quality-control systems, smart glasses, and imaging instruments. SureVision: SureVision. A method that evaluates refractive error in the human eye, with a disruptive, flicker-minimization method that is five times faster and two times more precise than the current gold-standard method. Modendo, Inc.: NeuroVu. Ultra-thin endoscopes for deep-brain imaging.