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In Vivo Imaging with FLIM Shows Effect of Experience on Neuronal Activity

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JUPITER, Fla., Dec. 30, 2019 — Every day, the neuronal connections within our brains change depending on what we learn and experience in our daily lives. Specialized proteins, called activity-dependent transcription factors, activate genes within the cells of the brain to help it translate this rapid incoming signaling into lasting neuronal changes. Until now, it has not been possible to directly monitor transcription factors activity. Scientists at the Max Planck Florida Institute for Neuroscience (MPFI) have designed and developed novel biosensors that will allow the simultaneous, in vivo study of both...Read full article

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    Published: December 2019
    Glossary
    fluorescence lifetime imaging
    Fluorescence lifetime imaging (FLIM) is an advanced imaging technique that provides information about the lifetime of fluorescence emissions from fluorophores within a sample. Unlike traditional fluorescence imaging, which relies on the intensity of emitted light, FLIM focuses on the time a fluorophore remains in its excited state before returning to the ground state. This fluorescence lifetime is influenced by the local environment and can be used for various applications in biological and...
    Research & TechnologyeducationAmericasMax Planck Florida Institute for NeuroscienceImagingLight SourcesOpticsFLIMin vivo imagingFRET2-photon imagingfluorescence lifetime imagingfluorescence resonance energy transferneuronal imagingmedicalBiophotonicsSensors & Detectorsbiosensors

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