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Imaging Method Lights up Brain Oxygenation

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ROCHESTER, N.Y., April 11, 2024 — Researchers at the University of Rochester and University of Copenhagen’s Center for Translational Neuromedicine developed a bioluminescence imaging technique that tracks the movement of oxygen in mice brains to reveal the level of oxygen present in the mice’s cortical tissue under different physiological conditions. As more oxygen enters the brain, the luminescence grows brighter. The method can be easily replicated by other labs and is expected to enable the forms of brain hypoxia, such as oxygen deprivation to the brain during a stroke or heart attack or in patients with...Read full article

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    Published: April 2024
    Glossary
    bioluminescence
    Bioluminescence is the natural phenomenon where living organisms produce light through a chemical reaction. In the context of photonics, bioluminescence has significant implications for both research and practical applications. Photonics, which involves the study and application of light, intersects with bioluminescence in several ways: Light production mechanism: Bioluminescence occurs when the enzyme luciferase catalyzes the oxidation of the molecule luciferin in the presence of oxygen....
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    Research & TechnologyeducationAmericasEuropeUniversity of RochesterUniversity of CopenhagenbioluminescenceneuroimagingAlzheimer’s diseaseImagingLight SourcesOpticsSensors & DetectorsTest & MeasurementoptogeneticsBiophotonicscoronavirusmedicalbrain tissue oxygenationoxygen deprivation

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