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Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport
DAEJEON, South Korea, Nov. 22, 2023 — Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of photobleaching and the visual isolation of cellular features from their environment limit the modality’s ability to glean information about the process and how it is conducted within the crowded cellular environment. Researchers at the Institute for Basic Science Center for Molecular
Plasma-infused Pulse Compression Proposes Pathway to Zettawatt Lasers
GLASGOW, Scotland, Nov. 21, 2023 — The ability to compress laser pulses to ultrahigh powers could open the way for compact lasers in the order of exawatt and above. Such powerful lasers would enable scientists to push the limits of physical science by deepening their study of the...
Light-Activated Tool Controls Protein Bonds and Tracks Cell Adhesion
TAMPERE, Finland, Nov. 20, 2023 — Optical tools can be used to activate biological functions, but with current methods the effects are slow to appear, and sustained effects require continuous light activation. As a result, these light-activation tools provide limited control of fast...
Algorithm Targets Microscope Resolution
BOSTON, Nov. 16, 2023 — Scientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the microscope’s point spread function, is one approach....
Hybrid Photoresist Helps Meet Demand for Smaller Chips
UPTON, N.Y., Nov. 14, 2023 — To achieve performance gains in microelectronics, semiconductor size continues to shrink, with feature sizes now in the sub-10-nm range. The challenges associated with the extreme downscaling of semiconductors have led to the adoption of a powerful...
Low-Power Optical Tweezers Protect Bioparticles from Damage
AUSTIN, Texas, Nov. 10, 2023 — Optical tweezers trap and manipulate minute particles with light. The technology is used across fields, ranging from manufacturing to biotech, though it requires the use of high-powered lasers to ensure proper function. These lasers can damage the...
Multimodal Solution Points to Broader Adoption of Metamaterials
POHANG, South Korea, Nov. 9, 2023 — Metamaterials, artificial nanostructures that manipulate light, are costly and technologically challenging to fabricate. The broad, practical use of metamaterials depends on lowering their manufacturing cost and making them easier to create....
Lasers Improve Phototherapy-Drug Delivery Platform
BALTIMORE, Nov. 7, 2023 — Photoimmunotherapy targets cancer cells with microscopic, nano-engineered cancer drugs that are light-activated at the lesion site. Although the technology is increasingly used to treat metastatic cancer, tools to improve the effectiveness of...
Virtual Superlens Passes Diffraction Limit Without Distortion
SYDNEY, Nov. 6, 2023 — The diffraction limit enforces physical restrictions on how closely an object can be examined using traditional optical methods. Previous attempts to develop superlenses that image beyond the diffraction limit have met with extreme visual losses, to...
Synthesized Nanoresonators Harness Power of IR for Optics and Electronics
STANFORD, Calif., Nov. 1, 2023 — When combined with electronics, infrared (IR) light can enable small, fast devices for sensing, imaging, and signaling at the molecular level. To fully harness the advantages of IR light, the materials used for IR optical and optoelectronic...
Photonic Crystals Imitate Gravitational Effects on Light
SENDAI, Japan, Oct. 25, 2023 — A group of researchers has replicated the way that light would behave if it were subject to gravity, supporting a recent scientific theory about pseudogravity. According to the theory, pseudogravity, a phenomenon replicating the effects of gravity,...
Compact Quasiparticle Light Source Could Rival FELs' Brightness
ROCHESTER, N.Y., Oct. 24, 2023 — An international team of scientists is rethinking the principles of radiation physics, with the goal of creating super-bright light sources that are compact and relatively convenient to use. Coherent light sources such as free-electron lasers (FELs)...
Fluorescence Lifetime Imaging Could Improve Cancer Surgery Outcomes
BOSTON, Oct. 24, 2023 — Extreme precision is required to surgically remove a cancerous tumor without damaging the surrounding healthy tissue. Yet surgeons often must rely on their eyes and hands to determine where to cut. Fluorescence lifetime (FLT) imaging, developed at...
Demonstration Moves On-chip Particle Accelerators One Step Closer
ERLANGEN, Germany, Oct. 23, 2023 — Particle accelerators range in size from a few square meters to large research centers. Using lasers to accelerate electrons within a photonic nanostructure constitutes a microscopic alternative with the potential of generating significantly lower...
Perovskite Cells Sustain Stability at High Temperatures
HONG KONG, Oct. 23, 2023 — Researchers at City University of Hong Kong have developed perovskite solar cells capable of maintaining stability at high temperatures. According to the researchers, the work paves the way to commercialization. Perovskite solar cells have been a...
Flexible Optogenetic Tool Blocks Pain, Not Movement
CAMBRIDGE, Mass., Oct. 20, 2023 — Engineers at MIT have developed soft and implantable fibers that can deliver light to major nerves through the body. When these nerves are genetically manipulated to respond to light, the fibers can send pulses of light to the nerves to inhibit...
Modified Photodiode Enables Multifunctional, High-Performance PICs
CHENGDU, China, Oct. 19, 2023 — Thin-film lithium niobate (TFLN) shows strong potential as a platform for integrated photonics, due to its robust electro-optic coefficient, large optical nonlinearity, and wide transparency window. TFLN is used in the development of various...
UV-based 3D Printing Accelerates Multipurpose Glass Production
ATLANTA, Oct. 18, 2023 — Current 3D-printing techniques for fabricating glass involve time-consuming processes that require high temperatures and considerable resources to complete. In a new approach, a research team at the Georgia Institute of Technology (Georgia Tech)...
Beamforming Reduces Photoacoustic Image Bias
BALTIMORE, Oct. 17, 2023 — Photoacoustic (PA) imaging offers a noninvasive means to obtain molecular and functional information about a variety of medical conditions. However, the quality of PA images, which are acquired when light illuminates the skin, is affected by the...
Birefringent Metasurface Aims to Transform Waveplate Tech
LIVERMORE, Calif., Oct. 17, 2023 — Lawrence Livermore National Laboratory (LLNL) researchers have adapted their novel metasurface process, which creates a thin layer on the surface of an optic, to create an all-glass metasurface with birefringence, or dual refraction, properties....
Femtosecond Laser Integrates Optics in Single Glass Substrate for Easy Manufacture
LAUSANNE, Switzerland, Oct. 16, 2023 — The short, regular pulses of femtosecond lasers are put to effective use in numerous applications, including laser surgery, micromachining, microscopy, and spectroscopy. Free-space optics offers substantial freedom in femtosecond laser design...
Deep Learning Delivers Optoacoustic Images in Real Time
MUNICH, Oct. 13, 2023 — High-quality medical imaging from multispectral optoacoustic tomography (MSOT) could be used to diagnose and evaluate a range of diseases, including breast cancer, Duchenne muscular dystrophy, IBD, and many more. However, the length of time...
Electro-Optic Modulators Improve Signal Quality and Cancel Noise
ORLANDO, Fla., Oct. 12, 2023 — Delays in optical data transmission cause inconvenient lag times in communications and interfere with immersive experiences like gaming. Two factors that adversely affect the speed and reliability of optical communication are signal distortion over...
Microscopy Method Detects Treatment-Resistant Cancer
BALTIMORE, Oct. 9, 2023 — Therapy-induced senescent (TIS) cells are cancer cells that become resistant to therapies and enter a dormant stage. These cells can emerge from dormancy and induce tumor resistance and relapse. To provide insight into how TIS cells evolve, it is...
OLED Pumping Enables Electrically Driven Semiconductor Lasing
ST. ANDREWS, Scotland, Oct. 6, 2023 — Researchers at the University of St. Andrews demonstrated an electrically driven, organic semiconductor laser using a new approach that could improve the performance of this class of laser and further the development of ultrafast, organic...

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