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The Silk (Optics) Road
An eco-friendly material that once united Europe and Asia in transcontinental trade shows promise for manipulating light in biosensors and more. Fiorenzo Omenetto, a biomedical engineering professor, heads the Laboratory for Ultrafast Nonlinear Optics and Biophotonics at Tufts University in Medford, Mass., where they are using silk in brand-new ways. Since joining Tufts in 2005, Omenetto has pioneered (with Dr. David Kaplan) the use of silk for photonics, optoelectronics and high-technolo...
BioPhotonics, December 2012
Choose the Right Light Source
As fluorescence microscopy advances, excitation light source selection becomes more important – and the best choice depends on the application. To take detailed images of biological structures, fluorescence microscopy relies on intense light....
BioPhotonics, November 2012
Laser Revascularization Method Could Help Where Bypasses Can’t
Transmyocardial laser revascularization fell somewhat out of favor in the 1990s, but recent developments have inspired new research into the technique. A laser technique that uses pulses of infrared light to blast channels into the heart muscle has...
BioPhotonics, November 2012
Opportunities Abound in Biological Spectroscopy
The market is expanding as the technology continues to develop, according to industry insiders. Spectroscopy allows us to analyze the world around us on an ever-smaller scale and with ever-better resolution. BioPhotonics recently spoke with a few...
BioPhotonics, November 2012
Probes Watch Your Heart Skip a Beat
Fluorescence enables optical mapping of cardiac arrhythmias While many cases of cardiac arrhythmia are harmless, others can lead to loss of heart function, breathing and consciousness, which can be dangerous and even fatal. And arrhythmias –...
BioPhotonics, November 2012
Fiber Optics Revolutionizes Neuroscience
An occasionally overlooked technology leads to major advances in the field Fiber optics might just be the Rodney Dangerfield of the photonics world: Despite being a workhorse technology that has contributed to countless studies over the years, it...
BioPhotonics, October 2012
Flexibility Improves Photoacoustic Microscopy
Switching from optical resolution to acoustic resolution allows scientists to extract more information from samples. Optical imaging offers the prospect of visualizing anatomical structures and detecting functional characteristics with nonionizing...
BioPhotonics, October 2012
Optical Microscopy Quantifies Live Cells Without Labels
With increasing frequency, noninvasive, label-free microscopy methods are capturing subcellular details in live cells and tissues at ever-smaller resolutions. Understanding the complex behavior and dynamics within live cells is key to exploring...
BioPhotonics, October 2012
Tell-Tale Color Changes: Camera Can Find Age of a Bruise
Changes in bruise color allow doctors to draw conclusions about when an injury occurred. To determine physical abuse of a child, several warning signs must be considered: Is the child scared? Are bruises present, and if so, where? What do the...
BioPhotonics, October 2012
Light Source Helps Endoscopes Get Smaller and Smaller
Xenon light sources represent the benchmark for medical illumination,but they cannot couple light through the small channels used for microendoscopes. Significant research has been undertaken to improve imaging sensors for endoscopy, but little work...
BioPhotonics, September 2012
Multimodal Label-Free Imaging Drives Biomedical Research
Label-free noninvasive, nondestructive optical microscopy using multiple simultaneous techniques allows researchers to observe diverse life processes in real time. Optical microscopy is a powerful tool in bioscience research, allowing researchers to...
BioPhotonics, September 2012
New Glass Fibers Widen Range of Medical Lighting Applications
Optical fibers with higher light transmission and longer life spans offer interesting new solutions for meeting the growing demand for higher quality lighting in medicine. New glass optical fibers offer longer lifetimes and higher light...
BioPhotonics, September 2012
The Age of the Tricorder
The medical device of the future is already here. The Star Trek television series and movies have proved remarkably prescient in anticipating future technologies – from flip phones to iPads – decades before they appeared in...
BioPhotonics, September 2012
From Waveform to Form Factor: Designing Laser-Based Medical Devices Has an Aesthetic All Its Own
When is a medical device a useful piece of equipment, and when is it an art form, pleasing to the eye and to the touch? If made with a careful eye to the needs of clinicians and patients alike, it can be both. Innovative device design can be an...
BioPhotonics, July 2012
In Vivo Studies Promise to Advance Diagnosis
Techniques that leave cell systems and organisms intact could provide a means to screen whole populations for disease less invasively and less expensively than traditional tests. In vivo optical techniques provide a wealth of information about the...
BioPhotonics, July 2012
Photocoagulation Refinements Are Decimating Birthmarks
(but Improving Birth Outcomes)
Precisely applied heat from the touch of a laser not only can hide blemishes, but can also save lives. For many, laser surgery brings to mind highly refined incisions made by coherent light pulses. Cutting, however, is not the only action a laser...
BioPhotonics, July 2012
Superresolution Microscopy Images Neurons on the Nanoscale
Recent advances allow superresolution microscopy to deliver on its promise of using focused light to provide glimpses of the inner workings of living organisms, resolving structures on the scale of tens of nanometers. The past decade witnessed a...
BioPhotonics, July 2012
Advanced Optics Deliver Drugs with IR Light
Biocompatible microparticles allow noninvasive, optically driven on-demand controlled release of methotrexate to treat psoriasis. Drugs are conventionally delivered orally or intravenously – but “conventional” does not always mean...
BioPhotonics, May 2012
CW DPSS Lasers Make STED Microscopy More Practical
Until now, stimulated emission depletion (STED) microscopy typically had been realized with the use of rather large and complex laser systems. But a setup for STED microscopy using a compact and low-noise 0.5-W, 660-nm, single-frequency...
BioPhotonics, May 2012
Fresh Ways to Shoot Faster Pictures
Muscles can move quickly – and individual proteins move even faster. So how do you capture such blazingly fast events? In the study of biological systems – cell biology being the premier example – nonlinear microscopy techniques...
BioPhotonics, May 2012
Improving Lives Through Spectroscopic Analysis
Noninvasive spectroscopy is aiding clinicians in the treatment of brain trauma, cancer and more. Measuring the amount of oxygen in blood carried by veins, arteries and even capillaries is a common diagnostic technique in hospital labs around...
BioPhotonics, May 2012
Lasers Match Performance to Application
OPSL technology has powered a paradigm shift in orange lasers for use in the life sciences by enabling wavelength and power to be customized to exactly match specific applications, instead of the other way around. For many years, applications in...
BioPhotonics, May 2012
Dynamic Phase-Shifting Microscopy Tracks Living Cells
The ability to instantaneously measure live cells – and follow motions and processes over time – helps researchers study dynamic cell behavior. Using harmless light levels – and without contrast agents – a dynamic...
BioPhotonics, April 2012
Maldi-MS Making a Strong Comeback
From cancer diagnosis and prognosis to the effects of applying medical leeches, the applications of Maldi imaging are growing. Higher throughput and a wider choice of instruments such as solid-state UV lasers have greatly improved the analytical...
BioPhotonics, April 2012
Nanoparticle Tracking Analysis Characterizes Biomaterials
Biomaterial characterization at the nanoscale is gathering interest, as a better understanding of properties such as particle size or number may provide new ways to look at nanotoxicology or provide pathways to the development of early diagnostic...
BioPhotonics, April 2012
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