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Diverse Applications Drive Lasers for Multiphoton Microscopy
After years of domination by a single ultrafast laser technology (Ti:S) and its associated add-ons, laser manufacturers have broadened their technology portfolios to better support a diversified and dynamic nonlinear imaging applications space.
BioPhotonics, March 2015
Raman Spectroscopy and Microscopy Enable Life Science Discoveries
The first article in this two-part series looked at Raman spectroscopy applications in tumor surgery, endoscopy and bacterial identification. This second part examines applications in cell sorting, laser trapping, biology probing and more.
BioPhotonics, March 2015
Lens-Free Microscopy Goes Scalable
A compact lens-free microscope could replace microscopes – and even expand their use – in a number of key biomedical applications, such as stem-cell culturing or in vitro drug testing. Using photonic integration, the microscope can even...
BioPhotonics, March 2015
Multiphoton Imaging Takes New Directions
Recent evolutions of ultrafast laser technology uniquely overcome key challenges in bioimaging, especially for long-term in vivo imaging, deep penetration and leveraging multimodal imaging strategies. Since the early 1990s – and even more so...
BioPhotonics, March 2015
Lasers, Optics Enhance Optogenetics Studies
A guide to suitable light sources and fiber optic components for optogenetics research, with a specific emphasis on rodent behavior. The use of lasers and optics for optogenetics is only in its infancy. In the next decade, we can expect researchers...
BioPhotonics, January 2015
Line-Narrowed Laser Module Enables Spin-Exchange Optical Pumping
The optical technique enhances MRI technology for diagnosis and other applications. In the past several decades, medical imaging has made huge strides. The field of MRI in particular has seen huge advancements in technical capability, as recognized...
BioPhotonics, January 2015
Microspectroscopy Enables Real-Time Imaging of Singlet Oxygen
A new experimental setup allows researchers to monitor a highly reactive species of molecular oxygen that plays an important role in a wide range of biological processes. Oxygen is one of the most important molecules in maintaining life, as well as...
BioPhotonics, January 2015
Raman Spectroscopy and Microscopy: Solving Outstanding Problems in the Life Sciences
This first article in a two-part series will examine Raman spectroscopy applications in tumor surgery, endoscopy, bacterial identification and more. The second part will cover applications in cell sorting, laser trapping and probing biology. Raman...
BioPhotonics, January 2015
Selecting a Microscope Based on Imaging Depth
Optical microscopy has advanced greatly over the past decade. Here’s how to select the right instrument for any particular application. Selecting the right optical microscopy system relies on a variety of factors: whether the instrument will...
BioPhotonics, January 2015
Photonics Innovators Named 2015 Prism Awards Finalists
Finalists include tools for 3-D printing, water analysis and laser-engineered surfaces. Innovative products, inventions and companies will take center stage Feb. 11, as the winners of the 2015 Prism Awards for Photonics Innovation are honored during...
Photonics Spectra, January 2015
Collaboration Advances Intraoperative Assessment of Tumor Margins
Physicians, companies come together to address clinical translation issues. It’s a long-standing truth: For the biophotonics community to meet the needs and constraints of the medical field and to translate technological advances for clinical...
BioPhotonics, December 2014
Global-Shutter vs. Rolling-Shutter Readouts
New sCMOS cameras overcome rolling-shutter artifacts by combining the best of both global and rolling shutters to achieve the simultaneous exposure with all rows, all while maintaining the frame rate and low noise benefits of rolling-shutter...
BioPhotonics, December 2014
STED Microscopy Made Easy
Stimulated emission depletion microscopy surpasses diffraction-limited microscopy by offering much more information about structures. Combining STED with time-tagged data acquisition methods makes even more information available. With fluorescence...
BioPhotonics, December 2014
Top Biophotonics Stories of 2014
QCL-based glucose testing, hyperspectral imaging and molecular techniques lead the list of the year's most popular stories.
BioPhotonics, December 2014
Printed Optics Usher in New Era of Manufacturing
Additive manufacturing techniques are set to revolutionize fabrication and integration of optical products for a variety of applications, from lighting to imaging and beyond. Additive manufacturing techniques are creating a new awakening in optics...
Photonics.com, December 2014
Imaging At The Speed Of Life
On the road to ultrafast imaging, bottlenecks include both hardware and software – but researchers are working to overcome these challenges. Being able to take a faster snapshot could benefit bio researchers – and the rest of us, too....
BioPhotonics, November 2014
Laser Combiner Enables Scanning Fluorescence Endoscopy
A laser-scanning fiber endoscope uses a plug-and-play laser combiner to enable high-contrast images suitable for detecting early-stage precancerous lesions. Detection of early cancerous lesions using molecular imaging can improve disease diagnosis...
BioPhotonics, November 2014
Multispectral Sensor Boosts Molecular Diagnostics
A new low-cost multispectral fluorescence detection sensor helps overcome barriers to using molecular diagnostics in point-of-care testing. In molecular diagnostics, fluorescent probes are used for detection of specific genetic material associated...
BioPhotonics, November 2014
UV-VIS Spectroscopy in the Clinic – What’s Stopping It?
The technique has been around for years and shows great promise, but so far researchers have been frustrated in their attempts at clinical translation. Imaging techniques using UV-VIS spectroscopy hold promise for a range of important clinical...
BioPhotonics, November 2014
Shorter Wavelengths, Pulses Power Laser Manufacturing
Recent laser advances are bringing benefits to manufacturing applications involving drilling, cutting and welding. More powerful diode lasers could, in the future, do more of these jobs directly, instead of being used to pump another material. The...
Photonics.com, October 2014
Color Management Helps Microscopy Show Its True Colors
Establishing a standard could allow microscopists to verify and reproduce results. Laboratory managers and researchers generally agree that having more accuracy and consistency in color rendition could assist in achieving improved evaluation of...
BioPhotonics, October 2014
Lessons Learned in Biophotonic Systems Design
New multiparametric modeling tools drastically simplify the design of complex biophotonic systems. For all the sophistication of modern engineering practice, the design of complex biophotonic systems remains as much an art as a science. This means...
BioPhotonics, October 2014
Multiphoton Microscopy Is Heading for the Mainstream
The technology could advance a range of neuroscience applications. As a postdoc in the early 2000s, Dr. Ruth Empson worked with one of the first multiphoton microscopy systems in Britain. The technology was robust, she said, but handling it could...
BioPhotonics, October 2014
Optogenetics Advances Ultrafast Lasers
Genetically encoded probes are driving the development of customized lasers for this red-hot area of neuroscience. The growing array of genetically encoded fluorescent probes is revolutionizing many areas of neuroscience, allowing researchers to...
BioPhotonics, October 2014
Mini Camera Modules Pave Way for Less-Invasive Visualization
Wafer-level packaging, CMOS circuits and MOEMS technologies help realize sub-1-mm camera modules. Imaging and small-sized digital camera modules have become ubiquitous. Only a few years ago, a digital camera recorder was still a considerable...
BioPhotonics, September 2014
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