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Microscopy News
Affordable Light-Sheet Microscope Could Spur Biomedical Exploration
TOKYO, July 22, 2024 — By broadening the availability of light-sheet fluorescence microscopy (LSFM) world-wide, a team at Juntendo University is helping to smooth the path to future discoveries in biomedicine. Advancements in tissue clearing techniques have made LSFM systems an important tool for biomedical research. However, the complexity and high cost of these systems have put them out of the reach of many end-users in the biomedical field. Greater accessibility to tissue clearing techniques could help
Objective Specifications Drive Performance in Biomedical and Life Sciences Research
Jul 7, 2024 — Microscope objectives are critical for a vast range of biological imaging applications, such as isolating cellular dynamics and cancer diagnostics, but designing and building a microscope objective can be a complex and expensive endeavor (opening...
STED Microscopy Uncovers Signals Between Molecules
Jul 7, 2024 — Stimulation emission depletion (STED) microscopy is a mainstay in superresolution imaging, since scientists established its capability to drastically improve the lateral resolution present in traditional fluorescence microscopy. In recent years, it...
Computational Microscopy Method Removes Distortions and Guesswork
PASADENA, Calif., July 4, 2024 — Computational imaging, a technique that combines the sensing capabilities of conventional microscopy with algorithms for processing data, helps modern microscopy achieve high-resolution, aberration-free images with a large field of view (FOV)....
Cytometer Detects Rare Cancer Cell Subpopulations Concurrently
BOSTON, June 20, 2024 — A new flow cytometry system could help scientists develop more targeted, personalized strategies for treating cancer by enabling them to follow disease progression and therapeutic response in different cancer cell subpopulations simultaneously....
Programmable Sensor Provides Fast, High-Quality Imaging of Neural Changes
CAMBRIDGE, Mass., June 18, 2024 — To study brain functions like memory, neuroscientists track the electrical communications of neurons. These voltage changes can be subtle and can happen on a millisecond timescale. A programmable image sensor from MIT could improve the ability to...
Optofluidic Antenna Enhances Single-Molecule Sensitivity in Liquid
ERLANGEN, Germany, May 13, 2024 — Single-emitter fluorescence detection is used in diverse fields, from biophysics to quantum optics, to precisely observe processes at the single-molecule level. When performed under fluidic conditions, diffusion restricts the observation time and...
Photoswitchable Biosystems Make Way for Intelligent Drug Delivery
POTSDAM, Germany, May 8, 2024 — A photoswitchable biosystem for the development of synthetic cells could provide a noninvasive way to design intelligent drug delivery systems for cell repair, advancing applications in photopharmacology. A team from the Max Planck Institute of...
Quantitative Phase Microscopy Tracks Drug Therapies
May 5, 2024 — Examining the cycle of life through the lens of a microscope is a fundamental practice in biology. As researchers have delved deeper into the microscopic world, a pursuit for higher resolution has ensued, leading to discoveries about the smallest...
3 Questions with Irina Larina
May 5, 2024 — BioPhotonics spoke with Irina Larina, professor in the Department of Integrative Physiology at Baylor College of Medicine. She is an SPIE Senior Member and a Fellow of Optica. She spoke to us about her team’s recent experiments using an...
Generative AI Achieves Superresolution with Minimal Tuning
GÖRLITZ, Germany, May 2, 2024 — Diffusion models for artificial intelligence (AI) produce high-quality samples and offer stable training, but their sensitivity to the choice of variance can be a drawback. The variance schedule controls the dynamics of the diffusion process, and...
Microprism-Mediated Calcium Imaging Reveals Neural Dynamics Over Time
SEATTLE, April 10, 2024 — An approach to deep brain imaging developed at the University of Washington uses microprisms to provide stable tracking of neuronal activity over a large field of view. According to the research team, the microprism technique is a significant...
Wavelength-specific Index Guides Laser Skin Treatment
OSAKA, Japan, April 4, 2024 — Laser treatment has gained popularity for the treatment of skin blemishes. To improve the efficacy and reduce complications from laser treatment, a research group led by Osaka Metropolitan University developed an index of the threshold energy...
Deep Learning Model Helps Target Prostate Cancer Treatments to Individual
SEATTLE, April 2, 2024 — Approximately 250,000 men in the U.S. receive a prostate cancer diagnosis each year. While overall morbidity and mortality rates for this type of cancer are low, a subset of cases requires aggressive treatment. A machine-learning model developed by...
AI, Lasers Automate Rapid Sorting and Analysis of Live Cells
AACHEN, Germany, March 25, 2024 — To realize the potential of personalized medicine and overcome crisis situations like the recent pandemic, labs need an efficient way to isolate living cells for analysis and testing. The ability to isolate specific cell types without impairing cell...
Light-Beads Microscopy Reveals New Information About Brain Activity
NEW YORK, March 14, 2024 — Mammalian brains are known to be comprised of densely interconnected neurons, but a remaining mystery in neuroscience is how tools which capture relatively few components of brain activity have enabled scientists to predict behavior in mice. To...
DMD-Based SIM Attains Fast Superresolution Imaging in 3D
BEIJING, March 4, 2024 — Although structured illumination microscopy (SIM) demonstrates ultrahigh temporal and spatial resolution, the speed and intricacy of polarization modulation affect the speed and quality of its imaging resolution in 3D. A 3DSIM technique, developed...
SPAD Elevates Spatiotemporal Resolution in Conventional Microscopes
GENOA, Italy, Feb. 23, 2024 — Image scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides better signal-to-noise ratio (SNR), optical sectioning, and spatial resolution better than that of a traditional...
Optical Control of Biofilm Growth Supports Biomaterials Advancements
LOS ANGELES, Feb. 12, 2024 — As sources of antibiotic-resistant bacteria, biofilms can cause serious issues in health care and other industries. Conversely, biofilms of harmless bacteria can be used to develop new biomaterials. The power to optically control biofilm formation...
Optoacoustic Imaging Reveals Scope of Pancreatic Cancer at Early Stage
OKLAHOMA CITY, Feb. 8, 2024 — A new imaging technique could improve survival rates for pancreatic cancer by enabling physicians to detect the full extent of the disease in its early stages. The technique pairs a contrast agent with multispectral optoacoustic tomography (MSOT) to...
Bruker Makes Fourth and Fifth Acquisitions of 2024
BILLERICA, Mass., Feb. 7, 2024 — In separate transactions, Bruker has acquired preclinical in-vivo optical imaging systems company Spectral Instruments Imaging (SII), and Nanophoton Corporation, a provider of advanced research Raman microscopy systems. Financial terms of the...
High-Throughput Imaging Reveals Multi-Particle Cellular Activity
BONN, Germany, Feb. 5, 2024 — A new software program can map the movements of multiple particles within cells simultaneously, providing insight into cellular functions that are difficult — and sometimes impossible — to investigate using single-cell tracking methods....
Machine Learning Hones Ability to Image Liver Disease
TOKYO, Jan. 29, 2024 — A research team at the Tokyo University of Science (TUS) has combined NIR hyperspectral imaging (NIR-HSI) and machine learning to assess lipid content in the liver. The technique enables noninvasive diagnosis of steatotic liver disease (SLD),...
Optofluidic Device Tests for Blood Disorders at Point of Care
HARBIN, China, Jan. 25, 2024 — Abnormalities in white blood cell count are indicative of a blood disorder. Measuring these abnormalities is imperative. However, the use of flow cytometry and other conventional methods to assess white blood cell concentration is confined to...
AI-aided Implant Captures Deep Brain Images
SAN DIEGO, Jan. 23, 2024 — A neural implant developed at the University of California San Diego could help advance the path to minimally invasive brain-computer interface (BCI) technology. The implant provides high-resolution data about deep neural activity by recording at...
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Jul/Aug 2024
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Objective Specifications Drive Performance in Biomedical and Life Sciences Research
BioPhotonics
, Jul/Aug 2024
Raman Spectroscopy for Point-of-Care Blood Testing
BioPhotonics
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BioPhotonics
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