The nVoke brain mapping platform from Inscopix Inc. combines calcium imaging and optogenetics into a single platform for precise measurement and modulation of brain activity patterns with light. nVoke empowers brain researchers with technological capability in testing the causal relationship between electrical activity in specific populations of nerve cells and behavior, and in deciphering the functional interactions between groups of neurons within and across brain regions. nVoke represents a major step forward in the development of a new generation of precise, closed-loop “all-optical” devices for understanding and possibly even correcting the pathophysiology underlying psychiatric and neurological disorders such as depression, Parkinson's disease and epilepsy.