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BioPhotonics Newsletter — Fiber Optic Probes, QCL-IR Powering Photoacoustic Spectroscopy, and more… (10/25/2023)

BioPhotonics Newsletter — Fiber Optic Probes, QCL-IR Powering Photoacoustic Spectroscopy, and more…

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Wednesday, October 25, 2023

Monthly newsletter focusing on how light-based technologies are being used in the life sciences. Includes news, features and product developments in lasers, imaging, optics, spectroscopy, microscopy, lighting and more. Manage your Photonics Media membership at Photonics.com/subscribe.

Fiber Optic Probes Help Customize Spectroscopic Diagnosis
Diffuse reflection spectroscopy and fluorescence spectroscopy are having a major effect in medicine and the life sciences, with expanding application in physics, chemistry, biology, and medicine. And fiber optic-based probes are becoming an essential and versatile solution for collecting the necessary spectroscopic measurements for analysis. This data ultimately informs both in vivo and in vitro analysis and diagnosis to detect cancer cells or the presence of specific diseases and may in some instances render traditional biopsies unnecessary.

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QCL-IR Powers Photoacoustic Spectroscopy in Translational Medicine
Mid-infrared (MIR) optoacoustic spectroscopy is a well-established technique that is currently being leveraged with modern instrumentation to push boundaries in life sciences research and medical diagnostics. Researchers recently demonstrated significant improvements to MIR optoacoustic imaging and detection techniques that have yielded promising results in noninvasive glucose monitoring and label-free analytic histology as well as other applications.

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Optofluidic Micromanipulations Show Aptitude in Laser Biomedicine
Techniques for micromanipulation support nanostructure assembly, particle trapping, and the spatiotemporal analysis of cell organization. Introducing optically induced thermoviscous flows can be used to optically move the cytoplasm in cells and developing embryos, for example, and can be used in intracellular rheology. Scientists at Karlsruhe Institute of Technology have now developed nearly isothermal scan sequences that exploit symmetry relations during laser scanning to disentangle laser heating and flow induction. The researchers’ scan sequences use dynamic photothermal stimuli and spatiotemporal symmetry relations of scanning bridging up to three distinct timescales.

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.: Featured Products & Services

Shop Motors Online @ Motion Plus

Motion Plus LLC
Unlock unparalleled precision in biophotonics with MOONS stepper motors at Motion Plus. Dive into transformative solutions, ensuring unmatched accuracy for your instruments. Join a community pushing boundaries. Discover the future of precision today.

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Microscopy, OCT & Focus Scanners

PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
PI's new Fast Focus Stages and Multi-Axis Piezo Scanning Stages for OCT, Microscopy, Focus Control, and Imaging provide higher speed and resolution than conventional scanning stages. These nanopositioning stages are available with piezo motors and voice coil motors.

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Introducing ThermoCube II

Solid State Cooling Systems
Solid State Cooling Systems is pleased to introduce the next generation of our legendary ThermoCube thermoelectric recirculating chiller. With no compressor or harmful refrigerants, ThermoCube II offers precise (±0.05 °C) temperature control, long-life reliability, and a wide variety of configuration options.

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Bring Your Next Product to Market

Optikos Corporation
Optikos engineering services will help bring your next medical device or diagnostic product from design to market. Optics makes amazing things possible in life sciences, and Optikos makes it happen.

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Custom Optical Assemblies

Rocky Mountain Instrument Co. (RMI)
Custom optical assemblies for your life science applications including microscopy, spectroscopy, and biotech imaging. Proven technologies in fast prototyping, design consultation, and vertically integrated manufacturing.

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KeyLight™ by Phoseon Technology

Phoseon Technology Inc.
KeyLight™ is a compact light source that supports 3-7 channel fluorescence microscopy systems. It brilliantly illuminates your results by delivering intense, broad-spectrum UV and visible wavelengths for a wide variety of colors between 340 nm and 760 nm.

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Custom Microscopes and Optical Systems

Prior Scientific Inc.
Prior Scientific has developed OpenStand to offer a working platform to build OEM solutions and one-off customizations with excellent value for money and reduced development time. Whether developing new automation techniques and software or developing new imaging methods, you can quickly find that you need a microscope system tailored to your application.

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CELESTA Light Engine

Lumencor Inc.
CELESTA Light Engine houses seven lasers in a turnkey illuminator for fluorescence confocal spinning disk microscopy and spatially resolved transcriptomics. 1000 mW/color from the end of an optical fiber is powerful, intense, quiet, reproducible and consistent. High-end imaging and OEM instrumentation are well supported. Ask about customization.

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Multi-Immersion Objectives

Applied Scientific Instrumentation Inc.
ASI and Special Optics have developed two dipping objective lenses designed for light sheet microscopy of cleared tissue samples, including ASI’s ct-dSPIM. These objectives work in any refractive index media without a correction collar because of a unique curved first surface.

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The 2023 Photonics Buyers’ Guide

Photonics Media
The 2023 edition lists over 4000 companies under 1600 product categories. It also includes 30 articles from the Photonics Handbook. Use coupon code SP23 for a special offer!

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.: In Case You Missed It

Optogenetic Tool Blocks Pain, Not Movement
Engineers at MIT have developed soft and implantable fibers that can deliver light to major nerves through the body. When these nerves are genetically manipulated to respond to light, the fibers can send pulses of light to the nerves to inhibit pain. The optical fibers are flexible and stretch with the body.

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Deep Learning Delivers High-Quality Optoacoustic Images in Real Time
High-quality medical imaging from multispectral optoacoustic tomography (MSOT) could be used to diagnose and evaluate a range of diseases, including breast cancer, Duchenne muscular dystrophy, inflammatory bowel disease, and many more. However, the length of time currently required for MSOT to process high-quality images makes it impractical in clinical settings. To provide high-quality, real-time optoacoustic imaging via MSOT, researchers from the Bioengineering Center and the Computational Health Center at Helmholtz Munich and the Technical University of Munich developed DeepMB, a deep-learning framework. DeepMB expresses model-based reconstruction with a deep neural network.

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Wearable Sensor Could Lower Mortality Due to Postpartum Blood Loss
Postpartum hemorrhage, the leading and most preventable cause of maternal mortality, can be hard to detect, because physiological compensation mechanisms can mask excessive bleeding. To diagnose postpartum hemorrhage in its early stages, a multidisciplinary research team at Washington University in St. Louis developed a wearable optical device that is worn on the wrist. The device uses laser speckle flow index to continuously monitor the body’s compensatory mechanisms triggered by blood loss elsewhere in the body.

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.: Upcoming Webinars

Optimization of Surface Enhanced Spatially Offset Raman Spectroscopy for Applications in Pre-Clinical Cancer Imaging
Thu, Nov 16, 2023 1:00 PM - 2:00 PM EST
In the field of optical imaging, the ability to image tumors at depth with high selectivity and specificity remains challenging. Fay Nicolson of the Dana-Farber Cancer Institute and Harvard Medical School discusses the optimization of spatially offset Raman spectroscopy (SORS) instrumentation and imaging approaches as well as the subsequent application of SESORRS to pre-clinical cancer imaging and the delineation of tumor margins in Apcfl/+, Apcfl/+;KrasG12D/+, and finally GL261 mouse models of colorectal cancer and glioblastoma. Moreover, using a SESORRS approach, she demonstrates that it is possible to detect secondary, deeper-seated lesions through the intact skull. This approach enables improvements in the non-invasive detection of these cancers due to improvements in SNR, spectral resolution, and depth acquisition, and can complement clinically approved image-guided surgical techniques.

.: Next Issue:

Features
Virtual Staining of Tissue, Raman Photothermal Microscopy, Medical Sensors in fNIRS, and Optical Filters in Raman Spectroscopy

Photonics Media is currently seeking technical feature articles on a variety of topics for publication in our magazine BioPhotonics. Please submit an informal 100-word abstract to Senior Editor Doug Farmer at [email protected], or use our online submission form www.photonics.com/submitfeature.aspx.

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