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Photonics Dictionary

vibrational circular dichroism

Vibrational circular dichroism (VCD) is a spectroscopic technique used to probe the chiral properties of molecules. It measures differences in the absorption of left- and right-circularly polarized light by a sample as a function of the vibrational frequency of the molecules within the sample. VCD spectroscopy is particularly useful for determining the absolute configuration and conformational properties of chiral molecules in solution or in the solid state. It provides valuable structural information about molecules, especially those with complex structures such as proteins, peptides, and natural products.
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