In Vivo Optoacoustic Microscopy System

• Company: TomoWave Laboratories Inc.
• Type: Scanning Probe
• Applications: Medical/Clinical Science, Life Science
• Lateral Resolution: 3 µm
• Axial Resolution: ~70 µm
• Signal-Noise Ratio: 40 dB
• Field of View: 30 mm×30 mm
• Penetration depth: 1.0 mm
• Wavelength: 660-1000 nm &1064 nm & 1200-1800 nm

Optoacoustic microscopy (OAM) is a microscopic imaging tool to provide in vivo optically sensitive images in a deeper region of a body. Typically, a real-time imaging capability is vital to identify specific diseases in preclinical and clinical uses. However, conventional OAM has slow imaging speed because of motorized stage.

We introduce a high-speed and high-SNR OAM system based on a fast OA scanner and transparent US transducer. The scanning ability in water makes the OA scanner possible to reflect both ultrasound and laser beam, simultaneously. Confocally aligned laser and ultrasound can scan the sample in fast manner. By pairing with motorized stage module, this hybrid OAM system results in a wide scanning range with a high speed in both optical resolution (OR) and acoustic resolution (AR) OAM.