The U.S. Department of Energy (DOE) will fund three Microelectronics Science Research Centers with $179 million over four years. The three centers, authorized by the Micro Act passed in the CHIPS and Science Act, will perform basic research in microelectronics materials, device and system design, and manufacturing science to transform future microelectronics technologies. The centers are formed as networks of projects; 16 in total led out of 10 national laboratories were selected by competitive peer review. The Microelectronics Energy Efficiency Research Center for Advanced Technologies (MEERCAT) will advance integrated innovations across materials, devices, information-carrying modalities, and systems’ architectures. Focusing on intelligent sensing, data bandwidth, multiplexing, and advanced computing, the center will explore transformative solutions that seamlessly bridge sensing, edge processing, artificial intelligence, and high-performance computing. (From left) Lawrence Livermore National Laboratory researchers Drew Willard, Brendan Reagan, and Issa Tamer work on the Big Aperture Thulium laser system, one of the projects designated under the Extreme Lithography & Materials Innovation Center (ELMIC). Courtesy of Lawrence Livermore National Laboratory/Jason Laurea. The Co-design and Heterogeneous Integration in Microelectronics for Extreme Environments (CHIME) Center will develop extreme environment electronics through heterogeneous integration and a seamless fusion of diverse materials, processes, and technologies to enable next-generation systems. The center will create robust, high-performance solutions capable of excelling in the most challenging conditions, including extreme thermal and radiation environments. The Extreme Lithography & Materials Innovation Center (ELMIC) aims to advance the fundamental science driving the integration of new materials and processes into future microelectronic systems, focusing on key areas such as plasma-based nanofabrication, extreme UV photon sources, 2D-material systems, and extreme-scale memory. The center’s scientific investigations will be informed strongly by a systems-to-physics motivation aimed at long term impact.