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Excelitas Technologies Corp. - X-Cite Vitae LB 11/24

Optogenetic Technique Screens for Cardiac Drug Safety

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An optogenetic technique has been used to make cardiac cells beat and optically measure their response, enabling an automated drug-testing process called OptoDyCE. The fully automated system for all-optical cardiac electrophysiology can rule out potentially dangerous drugs by testing 30,000 light-responsive cells in less than 10 min, a process that currently takes hours or even years. Using optogenetics, "spark" cells (green) and automation, Professor Emilia Entcheva's lab at George Washington University speeds up the process of drug screening in heart cells (red) to help bring safer...Read full article

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    Published: June 2016
    Glossary
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    Research & TechnologyeducationAmericasWashingtonGeorge Washingtonpeoplealeks klimasoptogeneticsBiophotonicsEmilia Entchevacardiologypharmaceuticalsdrugheart diseaseBioScan

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