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Holography Helps Measure Drug Action in Cells

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WEST LAFAYETTE, Ind., March 26, 2007 -- Using a laser and the same microchip found in digital cameras, a new digital holographic imaging system peers inside tumor cells and produces real-time, 3-D images that can be used to measure response to anti-cancer drugs. The device also may have applications in drug development and medical imaging. "This is the first time holography has been used to study the effects of a drug on living tissue," said David D. Nolte, the Purdue University physics professor who leads the research team. "We have moved beyond achieving a 3-D image to using that image for a direct physiological measure of...Read full article

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    Published: March 2007
    Glossary
    cell
    1. A single unit in a device for changing radiant energy to electrical energy or for controlling current flow in a circuit. 2. A single unit in a device whose resistance varies with radiant energy. 3. A single unit of a battery, primary or secondary, for converting chemical energy into electrical energy. 4. A simple unit of storage in a computer. 5. A limited region of space. 6. Part of a lens barrel holding one or more lenses.
    holography
    Holography is a technique used to capture and reconstruct three-dimensional images using the principles of interference and diffraction of light. Unlike conventional photography, which records only the intensity of light, holography records both the intensity and phase information of light waves scattered from an object. This allows the faithful reproduction of the object's three-dimensional structure, including its depth, shape, and texture. The process of holography typically involves the...
    image
    In optics, an image is the reconstruction of light rays from a source or object when light from that source or object is passed through a system of optics and onto an image forming plane. Light rays passing through an optical system tend to either converge (real image) or diverge (virtual image) to a plane (also called the image plane) in which a visual reproduction of the object is formed. This reconstructed pictorial representation of the object is called an image.
    laser speckle
    Sparkling granular pattern that is observed when an object diffusely reflects coincident laser light. Speckle appears as an irregularity in many holographs but has been exploited as a measurement technique. See also speckle metrology.
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    3-DanticancerBiophotonicsCCDCelldrug developmenthologramsholographic filmholographic imagingholographyimagelaser ranginglaser specklelight wavesmedical imagingMicronMicroscopyNews & FeaturesNolteorganellephotonicsPurduePurdue UniversitysemiconductorsSensors & Detectorsshimmertumor

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