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Excelitas Technologies Corp. - X-Cite Vitae LB 11/24

Fluorescent Probe Finds S. Aureus Inside Infected Hearts

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BOSTON, Aug. 23, 2011 — A novel imaging probe may make it possible to diagnose accurately a dangerous infection of the heart valves. Investigators at Massachusetts General Hospital (MGH) found that the presence of Staphylococcus aureus-associated endocarditis in a mouse model can be unveiled by PET imaging using a radiolabeled version of a protein involved in a process that usually conceals infecting bacteria from the immune system. “Our probe was able to sense whether S. aureus was present in abnormal growths that hinder the normal function of heart valves,” said Matthias Nahrendorf of the MGH...Read full article

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    Published: August 2011
    Glossary
    positron emission tomography
    A medical imaging device that uses a ring of crystal/photomultiplier tube assemblies encircling the patient to detect gamma rays emitted by positrons colliding with electrons.
    AmericasbacteriaBasic ScienceBiophotonicscomputed tomographyendocarditisfibrinfibrinogenfluorescence molecular tomographyFMT-CTheart valvesImagingimaging probesMassachusettsMassachusetts General HospitalMatthias NahrendorfMGH Center for Systems BiologyPET imagingPET-CTpositron emission tomographyprothrombinResearch & TechnologystaphylocoagulaseStaphylococcus aureusvegetations

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