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Microscopy News
Photoswitchable Biosystems Make Way for Intelligent Drug Delivery
POTSDAM, Germany, May 8, 2024 — A photoswitchable biosystem for the development of synthetic cells could provide a noninvasive way to design intelligent drug delivery systems for cell repair, advancing applications in photopharmacology. A team from the Max Planck Institute of Colloids and Interfaces, led by researcher Rumiana Dimova, demonstrated that interactions between a synthetic cell membrane and glycinin protein condensates integrated in the cell can be manipulated with light, and that such modulation can lead to
Generative AI Achieves Superresolution with Minimal Tuning
GÖRLITZ, Germany, May 2, 2024 — Diffusion models for artificial intelligence (AI) produce high-quality samples and offer stable training, but their sensitivity to the choice of variance can be a drawback. The variance schedule controls the dynamics of the diffusion process, and...
Microprism-Mediated Calcium Imaging Reveals Neural Dynamics Over Time
SEATTLE, April 10, 2024 — An approach to deep brain imaging developed at the University of Washington uses microprisms to provide stable tracking of neuronal activity over a large field of view. According to the research team, the microprism technique is a significant...
Wavelength-specific Index Guides Laser Skin Treatment
OSAKA, Japan, April 4, 2024 — Laser treatment has gained popularity for the treatment of skin blemishes. To improve the efficacy and reduce complications from laser treatment, a research group led by Osaka Metropolitan University developed an index of the threshold energy...
Deep Learning Model Helps Target Prostate Cancer Treatments to Individual
SEATTLE, April 2, 2024 — Approximately 250,000 men in the U.S. receive a prostate cancer diagnosis each year. While overall morbidity and mortality rates for this type of cancer are low, a subset of cases requires aggressive treatment. A machine-learning model developed by...
AI, Lasers Automate Rapid Sorting and Analysis of Live Cells
AACHEN, Germany, March 25, 2024 — To realize the potential of personalized medicine and overcome crisis situations like the recent pandemic, labs need an efficient way to isolate living cells for analysis and testing. The ability to isolate specific cell types without impairing cell...
Light-Beads Microscopy Reveals New Information About Brain Activity
NEW YORK, March 14, 2024 — Mammalian brains are known to be comprised of densely interconnected neurons, but a remaining mystery in neuroscience is how tools which capture relatively few components of brain activity have enabled scientists to predict behavior in mice. To...
DMD-Based SIM Attains Fast Superresolution Imaging in 3D
BEIJING, March 4, 2024 — Although structured illumination microscopy (SIM) demonstrates ultrahigh temporal and spatial resolution, the speed and intricacy of polarization modulation affect the speed and quality of its imaging resolution in 3D. A 3DSIM technique, developed...
SPAD Elevates Spatiotemporal Resolution in Conventional Microscopes
GENOA, Italy, Feb. 23, 2024 — Image scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides better signal-to-noise ratio (SNR), optical sectioning, and spatial resolution better than that of a traditional...
Optical Control of Biofilm Growth Supports Biomaterials Advancements
LOS ANGELES, Feb. 12, 2024 — As sources of antibiotic-resistant bacteria, biofilms can cause serious issues in health care and other industries. Conversely, biofilms of harmless bacteria can be used to develop new biomaterials. The power to optically control biofilm formation...
Optoacoustic Imaging Reveals Scope of Pancreatic Cancer at Early Stage
OKLAHOMA CITY, Feb. 8, 2024 — A new imaging technique could improve survival rates for pancreatic cancer by enabling physicians to detect the full extent of the disease in its early stages. The technique pairs a contrast agent with multispectral optoacoustic tomography (MSOT) to...
Bruker Makes Fourth and Fifth Acquisitions of 2024
BILLERICA, Mass., Feb. 7, 2024 — In separate transactions, Bruker has acquired preclinical in-vivo optical imaging systems company Spectral Instruments Imaging (SII), and Nanophoton Corporation, a provider of advanced research Raman microscopy systems. Financial terms of the...
High-Throughput Imaging Reveals Multi-Particle Cellular Activity
BONN, Germany, Feb. 5, 2024 — A new software program can map the movements of multiple particles within cells simultaneously, providing insight into cellular functions that are difficult — and sometimes impossible — to investigate using single-cell tracking methods....
Machine Learning Hones Ability to Image Liver Disease
TOKYO, Jan. 29, 2024 — A research team at the Tokyo University of Science (TUS) has combined NIR hyperspectral imaging (NIR-HSI) and machine learning to assess lipid content in the liver. The technique enables noninvasive diagnosis of steatotic liver disease (SLD),...
Optofluidic Device Tests for Blood Disorders at Point of Care
HARBIN, China, Jan. 25, 2024 — Abnormalities in white blood cell count are indicative of a blood disorder. Measuring these abnormalities is imperative. However, the use of flow cytometry and other conventional methods to assess white blood cell concentration is confined to...
AI-aided Implant Captures Deep Brain Images
SAN DIEGO, Jan. 23, 2024 — A neural implant developed at the University of California San Diego could help advance the path to minimally invasive brain-computer interface (BCI) technology. The implant provides high-resolution data about deep neural activity by recording at...
Raman Approach Safely Tracks Live-Cell RNA Expression
CAMBRIDGE, Mass., Jan. 22, 2024 — Single-cell RNA sequencing enables scientists to interrogate cells at extraordinary resolution and scale. However, the sequencing process destroys the cell, making it difficult to use the technique to study ongoing changes in gene expression. Raman...
Quantum-Inspired Method Reveals Details Hidden in Noise
WARSAW, Jan. 2, 2024 — Researchers at the University of Warsaw's Faculty of Physics with colleagues from Stanford University and Oklahoma State University have introduced a quantum-inspired phase-imaging method based on light intensity correlation measurements that is...
Bruker Continues Expansion, Acquiring Seven Companies
BILLERICA, Mass., Dec. 27, 2023 — In separate transactions, Bruker Corporation has entered into agreements to acquire in vitro diagnostics manufacturer ELITechGroup (ELITech), as well as cell imaging company Phasefocus. The acquisitions strengthen Bruker’s position in molecular...
Flow Cytometry Uncovers Predictive Biomarker for Severe COVID
MUNICH, Dec. 19, 2023 — Using image-based flow cytometry, researchers at the Technical University of Munich (TUM) identified a biomarker for predicting how serious a COVID-19 infection will be. They also developed a rapid test for assessing a patient’s risk of severe...
Two-Photon Holographic Mesoscope Probes Activity Across Large Brain Regions
BERKELEY, Calif., Dec.18, 2023 — Recent advancements in two-photon (2P) mesoscopes have extended the field of view (FOV) for deep brain imaging, making it possible to image brain regions as large as 25 mm2. Until now, though, mesoscopes could only measure neural signals; they could...
Evident, Partners Advance Live-Cell Imaging Instrumentation
WALTHAM, Mass., Nov. 29, 2023 — Life science imaging systems producer Evident has collaborated with illumination and imaging technology company 89 North and advanced microscopy systems producer CrestOptics to promote confocal spinning-disk technology to advance live-cell imaging....
Algorithm Boosts Live-Cell Imaging's Capabilities
OEIRAS, Portugal, Nov. 27, 2023 — Superresolution radial fluctuations (SRRF), a superresolution algorithm, works by observing fluctuations in radial symmetry throughout the frames of an image. SRRF supports live-cell, superresolution microscopy on a range of microscopy platforms...
Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport
DAEJEON, South Korea, Nov. 22, 2023 — Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of photobleaching and the visual isolation of cellular...
Light-Activated Tool Controls Protein Bonds and Tracks Cell Adhesion
TAMPERE, Finland, Nov. 20, 2023 — Optical tools can be used to activate biological functions, but with current methods the effects are slow to appear, and sustained effects require continuous light activation. As a result, these light-activation tools provide limited control of fast...
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Mar/Apr 2024
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