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Microscopy News
Advances in micro total analysis
Jul 1, 2006 — Andreas Manz and his colleagues at the Institute for Analytical Sciences in Dortmund, Germany, have reviewed recently developed micro total analysis systems technologies, analytical standard operations and applications of micro total analysis systems, focusing on fluidic systems and cellular applications. The authors note that many optical methods are used for detection in micro total analysis systems. Fluorescence microscopy, for example, is used to detect labeled drugs and proteins and...
Aperio Technologies Inc.
Jul 1, 2006 — Aperio Technologies Inc. of Vista, Calif., has received a US patent for its data management system, designed to work with the linear-array-based slide scanner. The patent is in keeping with the company’s main business of virtual microscopy,...
Building a Better — But Still Tiny — Sensor
Jul 1, 2006 — For an atomic force microscope, familiarity can breed better images — in more ways than one. When the microscope’s tip has a sensing molecule tethered to it, the molecule enables the device to recognize targets in the sample being...
Catching Cells Behaving Badly — or Not
Jul 1, 2006 — Employing high school students, inexpensive video cameras, standard desktop PCs and terabytes of storage, researchers have found new indicators that improve the detection of blood stem cells dividing in tissue culture. Through digital time-lapse...
Chemical microscopy
Jul 1, 2006 — Chemical microscopy is a development that could enable the study of chemistries within a cell in real time. New techniques are necessary to execute sensitive, selective, fast and in situ chemical measurements of micron-scale complex cellular systems...
FRET filters
Jul 1, 2006 — Available from Omega Optical Inc. is the FRET Application Note “Optimizing Filter Sets for Fret Applications.” Downloadable from the company Web site, the four-page document begins with an overview of the Förster resonance energy...
Lighting up nitric oxide with a little bit of copper
Jul 1, 2006 — Nitric oxide, an antioxidant primarily known for its role as a messenger in cellular signaling events, also is generated by cells to accomplish a variety of other tasks. Macrophages, for example, create it to eliminate bacteria and other foreign...
Medical Imaging Learns from Computer Gaming
Jul 1, 2006 — Medical imaging systems such as CT, MRI and ultrasound are becoming ubiquitous. As the technology becomes more commonplace, it also continues to mature. Significant imaging applications arise each year to aid in the diagnosis and monitoring of...
Nanopositioning
Jul 1, 2006 — The 215-page “Product Catalog 2005 & 2006” from attocube systems AG details nanopositioners for applications such as sample positioning in scanning probe microscopy. It presents low-temperature scanning probe microscopes equipped...
Olympus
Jul 1, 2006 — Olympus of Germany has just merged its subsidiaries Soft Imaging System and Olympus BioSystems into a new company, Olympus Soft Imaging Solutions GmbH. The new entity will focus on software and hardware system development for microscopy imaging...
Photonic crystal enables real-time cell viability monitoring
Jul 1, 2006 — As the pharmaceutical industry searches for new drugs, one of its biggest challenges is testing compounds and even multiple variants of a single compound. New drugs require hundreds of tests before one can even move beyond the initial testing...
Resolution of Optical Microscope Redefined
Jul 1, 2006 — Optical microscopy is an important tool for studying live biological cells in life sciences research, enabling the observation of various biological processes in real time. The study of nanoscale single molecular activities such as protein-protein...
Spectral Confocal Microscopy Aids FRET Studies
Jul 1, 2006 — FRET is an energy transfer between two fluorescent molecules that occurs without the exchange of a photon. It occurs when a fluorescent molecule, usually called the donor probe, is excited by the absorption of a photon. If a fluorescent probe that...
Syncroscopy
Jul 1, 2006 — Syncroscopy of Cambridge, UK, has agreed to allow Leica Microsystems of Wetzlar, Germany, to integrate its Auto-Montage Pro software with Leica’s Application Suite software. The resulting software has been dubbed LAS Montage and will be sent...
Two-color solid-state lasers could aid confocal microscopy
Jul 1, 2006 — Diode-pumped solid-state lasers are available at emissions near the 488-nm argon-ion laser line, which can be used for excitation in confocal microscopy and other fluorescence-based detection and imaging techniques. The solid-state lasers are small,...
Virtual histology method bolsters visualization of mouse embryos
Jul 1, 2006 — iologists use gene targeting in mice to further understand the causes of birth defects and childhood cancer. However, the technique they use entails careful and tedious histological sectioning of early embryos, a task that is not only...
A rubbery lens and microscope
Jun 1, 2006 — In a new twist on the idea of a flexible microscope, researchers at California Institute of Technology in Pasadena have constructed a functioning microscope out of rubber. Not only does the instrument work, but it also is small enough to be helpful...
Blurred images bring clarity
Jun 1, 2006 — Consider an actor on a stage. If he takes a few steps to his left, it is fairly easy to determine how far he moves and in what direction — the tools with which to do so are readily available. But then, as he continues, he begins to twist his...
CARS microspectroscopy combined with two-photon fluorescence
Jun 1, 2006 — When studying cells, Raman spectroscopy offers significant advantages. Because of its inherent molecular specificity, there is no need for staining or fluorescent tagging, so no potentially function-altering foreign materials will be introduced into...
Defocusing improves microscopic analysis of red blood cells
Jun 1, 2006 — Several years ago, Oscar N. Mesquita, a researcher with the Federal University of Minas Gerais in Belo Horizonte, Brazil, was measuring the movement of macrophages. At one point, he looked into the microscope before focusing and noticed that some of...
Direct Proximity Imaging with FRET and FLIM
Jun 1, 2006 — Florescent proteins have opened the possibility to observe protein distribution and localization by fluorescence microscopy. Directly observing these nanometer-size molecules is not possible, however. As an alternative, indirect methods such as...
Electron microscopy helps define HIV’s spikes
Jun 1, 2006 — On each particle of HIV, there are scattered several spikes — composed of glycoprotein — that initiate the infection of healthy cells. The glycoprotein is a candidate target for potential vaccines against the virus; however, little is...
Faster confocal technique explores heart’s pumping mechanism in vivo
Jun 1, 2006 — The cardiovascular system is the first functional organ system to develop, and the embryonic heart begins pumping blood before features such as chambers and valves are discernible. Until recently, scientists held that the valveless embryonic heart...
Fluorescence correlation spectroscopy helps clarify cell mitosis
Jun 1, 2006 — Understanding the processes at the heart of the cellular functions regulating mitosis, such as signal transduction, requires precise quantitation of the cell’s molecules. According to researcher Zifu Wang at the University of California,...
Gold stars offer new rewards
Jun 1, 2006 — The size- and shape-dependent emission of noble metal nanoparticles makes them useful for applications such as sensing and labeling and even for nanoscale optical waveguides. For sensing, these particles can detect molecular binding because their...
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May/Jun 2024
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