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Fluorescence News
NIH grant furthers Kinetic River Corp. cell analysis system
May 17, 2019 — The National Institutes of Health (NIH), via its National Institute of General Medical Sciences (NIGMS), has awarded Kinetic River Corp. a two-year Phase II Small Business Innovation Research (SBIR) grant to “support continued design, engineering, and validation efforts toward commercialization of [the company’s] new cell-analysis technology. After a successful Phase I feasibility project — also funded by NIGMS (an NIH institute that fosters extramural research focused on
Microfluidic Device with Fluorescent Sensor Detects Ebola
ROCHESTER, N.Y., May 15, 2019 — A faculty-researcher at Rochester Institute of Technology (RIT) has developed a prototype microdevice with biosensors that can detect the Ebola virus. The microfluidic device is an automated chip with a highly sensitive fluorescence sensing unit...
Improved Optical Multiplexing with Temporal DNA Barcodes
DURHAM, N.C., April 18, 2019 — In a new imaging technique developed at Duke University in collaboration with Oak Ridge National Laboratory, short strands of DNA were labeled with fluorescent, temporal “barcodes” for observing biochemical activity at the molecular...
CPI, LightOx Collaborate on Light Therapy for Skin and Oral Cancers
SEDGEFIELD, England, April 18, 2019 — The Center for Process Innovation (CPI) and LightOx are collaborating on a photonics project to advance the development of next-generation cancer treatments using phototherapeutic methods.
NIR Imaging System Could ID Hard-to-Detect Cancers Earlier
CAMBRIDGE, Mass., March 12, 2019 — An optical imaging system developed by MIT researchers could enable physicians to identify tiny tumors deep within the body, leading to earlier detection and treatment of cancer. The researchers call their system DOLPHIN, which stands for “Detection...
Upconversion Materials Empower Thermal Bioimaging
Mar 8, 2019 — Bioimaging is a fundamental technique for research in the life sciences, and it is used routinely in the medical industry. The procedure itself encompasses many different methods, such as electron microscopy, x-ray tomography, and magnetic resonance...
Fluorogenic Method Detects Two-Protein Aggregation in Live Cells
STATE COLLEGE, Pa., Feb. 15, 2019 — A new method uses fluorescence to detect potentially disease-causing forms of proteins as they misfold and unravel due to stress or mutations. Researchers from Pennsylvania State University (Penn State) and the University of Washington re-engineered...
Optical Microscopy System Observes, Stimulates Multiple Living Cells
KOBE, Japan, Jan. 30, 2019 — A new optical microscope uses holographic techniques to stimulate multiple cells simultaneously and monitor cell activity after stimulation. Developed by researchers at Kobe University and called SIFOM for three-dimensional (3D) Stimulation and...
PDT, Customized Protocols Team Up for Enhanced Clinical Translation
Dec 18, 2018 — Photodynamic therapy is a powerful technique in the local, selective treatment of cancer and infectious diseases, but customized optical device protocols must be added to the mix for major clinical translation. Photodynamic therapy (PDT) is a robust...
Molecular Imaging Emerges as a Cancer Surgery Tool
Dec 13, 2018 — Molecular imaging has become an invaluable tool in cancer treatment. Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are entering routine clinical use for preoperative imaging. These techniques visualize...
Miniaturization, Increased Resolution Drive Microscopy’s Future
Sep 12, 2018 — Miniature fluorescence microscopes and other system components, such as liquid lenses, are among emerging microscopy advancements that are bettering optical inspection in areas including the life sciences and machine vision. Now, such technology is...
Fluorescent Fish Genes Could Help Uncover Source of Pediatric Cancer
HOUSTON, July 17, 2018 — A transgenic zebrafish that produces fluorescent tags in migratory embryonic nerve precursor cells could help lead researchers to the origins of neuroblastoma, a pediatric cancer in which malignant cells form in immature nerve tissue. Undergraduate...
Plasmonic Patch Boosts Fluorescence for Biosensing, Bioimaging
ST. LOUIS, Mo., July 12, 2018 — To strengthen weak signals in fluorescence-based detection and imaging techniques, researchers have developed an inexpensive plasmonic patch that can increase fluorescence intensity up to 100×. The patch, about a centimeter square, is based on...
Optical Probes Allow Ultrafast, High-Resolution Imaging of Dopamine Activity
DAVIS, Calif., June 15, 2018 — Fluorescent sensors that optically record dopamine activity in the brains of behaving mice could help facilitate the discovery of therapeutics for depression and addiction. The technology precisely captures where and when dopamine activity occurs in...
Technique to Suppress Photobleaching Increases Imaging Window
OKINAWA, Japan, April 10, 2018 — To better understand how proteins move and interact within the cell membrane, an imaging method called live-cell single fluorescent-molecule imaging (SFMI) can be used to tag each protein in the membrane individually with fluorescent markers. The...
Microsensor Could Help Individualize Dialysis Treatment
EINDHOVEN, Netherlands, April 9, 2018 — A new microsensor could make it possible to directly monitor and adjust the composition of kidney dialysis fluid (dialysate) — an important step toward customizing dialysis to the individual patient. The sensor provides a way to monitor the...
Optical Tool Uses Fluorescence to Detect Metabolic Changes
MEDFORD, Mass., March 12, 2018 — An optical tool that can read metabolism at subcellular resolution could be used to identify specific metabolic signatures that could be indicative of disease. The method detects functional and structural metabolic biomarkers noninvasively using...
Nanocarbon Shows Promise for Fluorescent Bioimaging
NAGOYA, Japan, Feb. 22, 2018 — An international team from Nagoya University and Boston College has developed a flexible, water-soluble warped nanographene molecule that is biocompatible. The molecule was also found to induce cell death when exposed to light. The new molecule...
Fluorescent Sensor Detects Drug-Induced Protein Stress in Cells
STATE COLLEGE, Pa., Aug. 8, 2017 — A fluorescent sensor that becomes activated in a cell when misfolded proteins begin to aggregate could be an effective way to detect protein aggregates caused by drug-induced proteome stress prior to cell death. Researchers designed an unstable...
Near-Infrared Tumor Technology Identifies Cancerous Cells
PHILADELPHIA, Aug. 3, 2017 — Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) — using of a contrast agent that makes tumor cells glow during surgery — with...
Optogenetic Tool Efficiently Manipulates Protein Clusters
DAEJEON, South Korea, June 28, 2017 — An optogenetic technique dubbed CRY2clust is able to trigger protein cluster formation in response to blue light at a faster and more efficient rate than existing methods. CRY2clust is based on a photoreceptor protein called cryptochrome 2 (CRY2),...
Life Sciences Evolving With Confocal Microscopy
Jun 26, 2017 — Confocal microscopy is not a new technique for life sciences applications. But it has steadily advanced since its inception decades ago, becoming a valuable tool for the life sciences. The technique presents challenges, however, because it has a...
Laser World of Photonics: A Focus on Technology, Applications
Jun 16, 2017 — Bringing together all sectors of the photonics industry, Laser World of Photonics 2017 highlights research, companies’ new products and expert presentations. It also offers visitors and exhibitors to expand their networks and customer bases....
Microscopy Method Enables Simultaneous Imaging of 24 Molecules
NEW YORK, April 24, 2017 — A novel microscopy platform with enhanced detection sensitivity could allow for more comprehensive, system-wide labeling and imaging of greater numbers of biomolecules in living cells and tissues than is currently possible. The platform, called...
Optical Nanoscopy Images DNA Naturally Fluorescing
EVANSTON, Ill., March 3, 2017 — A novel imaging tool that is able to capture images of DNA naturally fluorescing could advance the study of individual biomolecules and help uncover global patterns of gene expression. Existing methods for imaging DNA and other genetic material rely...
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May/Jun 2024
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