Optimization of Surface Enhanced Spatially Offset Raman Spectroscopy for Applications in Pre-Clinical Cancer Imaging
Thu, Nov 16, 2023 1:00 PM - 2:00 PM EST
In the field of optical imaging, the ability to image tumors at depth with high selectivity and specificity remains challenging. Fay Nicolson of the Dana-Farber Cancer Institute and Harvard Medical School discusses the optimization of SORS instrumentation and imaging approaches as well as the subsequent application of SESORRS to pre-clinical cancer imaging and the delineation of tumor margins in Apcfl/+, Apcfl/+;KrasG12D/+, and finally GL261 mouse models of colorectal cancer and glioblastoma. Moreover, using a SESORRS approach, she demonstrates that it is possible to detect secondary, deeper-seated lesions through the intact skull. This approach enables improvements in the non-invasive detection of these cancers due to improvements in SNR, spectral resolution, and depth acquisition, and can complement clinically approved image-guided surgical techniques.
The Etendue Mystery Revealed
Tue, Nov 28, 2023 10:00 AM - 11:00 AM EST
Etendue is the most important and fundamental quantity in illumination optics while simultaneously the most mysterious, misunderstood, and misused quantity. This is because, under certain conditions, etendue follows a conservation law. Similar to all conservation laws, understanding etendue provides great insight into what can be achieved with illumination optics. The confusion instead comes from understanding under what conditions etendue follows this conservation law. In this presentation, Julius Muschaweck explains what etendue is, exactly when etendue is conserved, as well as how etendue can help to assess feasibility and guide the optical designer toward finding effective optical solutions.
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