A User Guide to Image Quality Assessment for Artificial Intelligence
Tue, Nov 29, 2022 10:30 AM - 11:30 AM EST
Dotphoton’s Arianne Bercowsky, Ph.D., presents insights into recent work involving standardization and image quality assessment to help future-proof image data. She also demonstrates Jetraw high-performance raw image compression technology, as a software for biomedical and pharma, followed by her colleague Bruno Sanguinetti, Ph.D. who demonstrates its field-programmable gate array (FPGA) implementation for camera manufacturers. Bercowsky and Sanguinetti are joined by Gerhard Holst, from one of Dotphoton’s partners, Excelitas PCO. Holst presents a case study performed by the Imperial College London on the outcome of applying Jetraw compression to light-sheet microscopes using PCO cameras. Presented by Dotphoton.
Fluorescence Lifetime Microscopy for Label-Free Imaging of Cellular Metabolism and Heterogeneity
Wed, Nov 30, 2022 1:00 PM - 2:00 PM EST
Alex Walsh, of Texas A&M University, shares on how cellular metabolism is dysregulated in many diseases and pathologies. Current biochemical assays for metabolism are limited to either cell-destructive protocols. Fluorescence lifetime imaging of the metabolic coenzymes, reduced nicotinamide adenine (phosphate) dinucleotide (NAD(P)H) and oxidized flavin adenine dinucleotide (FAD), provides a label-free method to interrogate cellular metabolism. Single-cell segmentation and analysis of fluorescence lifetime images allows metabolic measurements at the cellular level. To facilitate cell-level analysis of fluorescence images, researchers are developing automated segmentation algorithms. Additionally, they are creating and testing models for predicting cell phenotypes from fluorescence lifetime metrics.
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