Sub-Cellular Biology at Tissue Scales with Cleared Tissue Axially Scanned Light-Sheet Microscopy
Wed, Aug 17, 2022 1:00 PM - 2:00 PM EDT
Large-scale interdisciplinary efforts have worked to comprehensively catalog cellular architectures in health and disease. Kevin Dean Ph.D. shares on the scalable imaging platform, Cleared-Tissue Axially Swept Light-Sheet Microscopy (CT-ASLM), that helps further this research. The CT-ASLM leverages high-speed, aberration-free, remote focusing to achieve an isotropic resolution of approximately 300 nm-scale subcellular imaging with an unparalleled optical sectioning capacity and large field of view. The platform provides global tissue architectures as well as quantitatively detailed morphological and biochemical descriptions of the individual cells that compose tissues in health and in disease. Sponsored by Power Technology, Intelligent Imaging Innovations Inc., and Applied Scientific Instrumentation, Inc.
QCL Dual-Comb Spectroscopy Matures into the Mid-Infrared by Combining High-Time and High-Frequency Resolution
Tue, Aug 23, 2022 10:00 AM - 11:00 AM EDT
QCL dual-comb spectroscopy began with high time-resolved (250 µs-250ms) single shot measurements and has progressed to time-scales that can compete with rapid scan Fourier-transform infrared spectroscopy. Recent research has discovered a high-spectral resolution feature on instruments that allows measurements with less than one MHz resolution over a bandwidth of 50cm-1. This breakthrough was achieved by combining the high-time resolved mode with the high-spectrally resolved mode in supersonic beam measurements. Andreas Hugi, Ph.D. explains the technical background of these acquisition modes and links them to real world applications. Sponsored by Hamamatsu Corp.
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