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BioPhotonics Newsletter — Confocal Microscopy, Top Hat Illumination, and more… (2/22/2023)

BioPhotonics Newsletter — Confocal Microscopy, Top Hat Illumination, and more…
Monthly newsletter focusing on how light-based technologies are being used in the life sciences.
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Wednesday, February 22, 2023
Monthly newsletter focusing on how light-based technologies are being used in the life sciences. Includes news, features and product developments in lasers, imaging, optics, spectroscopy, microscopy, lighting and more. Manage your Photonics Media membership at Photonics.com/subscribe.

 
Acousto-Optic Components Overcome Limitations in Confocal Microscopy
Acousto-Optic Components Overcome Limitations in Confocal Microscopy
Confocal and multiphoton microscopy are commonly used to provide 3D-resolved images of in vitro or in vivo tissue samples without physical sectioning. But there are also inherent trade-offs in the use of these techniques when it comes to imaging depth, resolution, and speed. Recent developments in the use of acousto-optic and other photonic components integrated into a microscope are beginning to address these limitations in capability, opening up new opportunities in life science research.
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Top Hat Illumination Provides Even Light Distribution Across Samples
Top Hat Illumination Provides Even Light Distribution Across Samples
Two common illumination techniques used in microscopy are known as critical illumination and Köhler illumination, and each has advantages and disadvantages. Other lighting techniques are also available for a variety of biophotonics applications. A new lighting method that uses lenses with LEDs to produce flat, top hat illumination has emerged, yielding even distribution of illumination across any plane of interest. This approach greatly benefits life scientists who examine dynamic and intricate samples.
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Pump Laser Modules Show Promise for Ophthalmologic Treatments
Pump Laser Modules Show Promise for Ophthalmologic Treatments
Researchers at the Berlin-based Ferdinand-Braun-Institut (FBH) developed a pump laser module for ophthalmologic treatments. The module offers a cost-effective pump source for laser systems that are used to treat retinal detachments. The miniaturized module can be flexibly adjusted to provide the optimal wavelength for its intended application. The semiconductor-based, miniaturized laser module could provide a reliable, efficient way to provide laser surgery that is targeted to the condition being treated and could reduce the costs of ophthalmologic laser surgery.
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.: Featured Products & Services

 
Applied Scientific Instrumentation Inc. - Ultra Precise Piezo-Z Focus Stage Ultra Precise Piezo-Z Focus Stage

Applied Scientific Instrumentation Inc.
The stage is capable of XY resolutions down to the 10-20 nm and Z resolutions to the 1nm range. It is able for use with rapid z-sectioning and autofocus systems. It prevents focus drift when used with our CRISP system.

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Lumencor Inc. - CELESTA Light Engine CELESTA Light Engine

Lumencor Inc.
CELESTA Light Engine houses seven lasers in a turnkey illuminator for fluorescence confocal spinning disk microscopy and spatially resolved transcriptomics. 1000 mW/color from the end of an optical fiber is powerful, intense, quiet, reproducible and consistent. High-end imaging and OEM instrumentation are well supported. Ask about customization.

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PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics - Fast XYZ Photonics Aligner Fast XYZ Photonics Aligner

PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
This A-142-based XYZ photonics aligner can reduce alignment times by up to 99%. Its high-performance motion controller comes with embedded advanced alignment algorithms. Featuring zero-wear air bearings and direct drive motors, the system is well suited for 24/7 operation.

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Lambda Research Corporation - TracePro 2023 Released! TracePro 2023 Released!

Lambda Research Corporation
TracePro 2023 by Lambda Research Corporation is a comprehensive software with new features for illumination and optical design, including CAD and lens design importers. TracePro offers tools for designing medical devices, automotive lighting, illumination, display backlights, and more.

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Phoseon Technology Inc. - KeyLight™ by Phoseon Technology KeyLight™ by Phoseon Technology

Phoseon Technology Inc.
KeyLight™ is a compact light source that supports 3-7 channel fluorescence microscopy systems. It brilliantly illuminates your results by delivering intense, broad-spectrum UV and visible wavelengths for a wide variety of colors between 340 nm and 760 nm.

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American Elements - Advanced Materials and Chemicals for Optical Applications Advanced Materials and Chemicals for Optical Applications

American Elements
American Elements produces a wide range of advanced materials for optical, laser, electronics, and other applications. Products are engineered to meet rigorous quality standards and produced from ultra-high purity materials including sputtering targets, chemicals, pure metals, and nanomaterials.

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Motion Plus LLC - Precision Optomechanics: Stages, Mounts, Solutions Precision Optomechanics: Stages, Mounts, Solutions

Motion Plus LLC
Motion Plus features a wide range of optomechanical components for positioning mirrors, lenses, and filters. Products include kinematic mounts, mirror/lens holders, manual positioners, and more. In-Stock, high-quality solutions for lab or research use.

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IDEX Health & Science - Semrock Optical Filters - Step Through the Spectrum with Nanopede™ Filters Step Through the Spectrum with Nanopede™ Filters

IDEX Health & Science - Semrock Optical Filters
The Semrock Nanopede™ filter family, designed specifically for flow cytometry, provides a value approach to optical performance for your application. We understand each flow cytometry instrument is different, partner with us on custom optical filters to meet your specific application needs.

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.: In Case You Missed It

 
Time-Tagging Captures Cellular Activity with Single-Photon Microscopy
Time-Tagging Captures Cellular Activity with Single-Photon Microscopy
BrightEyes-TTM, an open-source time-tagging module (TTM) developed at the Italian Institute of Technology (IIT), enables scientists to observe the dynamic processes of molecules inside living cells over time, at a thousandth of a millisecond scale. BrightEyes-TTM can be used to study the variations that occur at the cellular level when a healthy cell becomes diseased.

Read Article
 
Isorg Collaborates with Precise Biometrics on Turnkey Fingerprint Sensor
Isorg, a developer of organic photodetectors (OPD) and large-area image sensors, has collaborated with Precise Biometrics, a provider of fingerprint verification software, on a new fingerprint-on-display solution for the mobile phone industry.

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STOC Tomography Advances Ophthalmological Imaging
Spatio-Temporal Optical Coherence Tomography (STOC-T), an ophthalmological imaging technique originally invented to capture optoretinograms, has been enhanced by its developers at the International Centre for Translational Eye Research (ICTER) to enable views of the retina and choroid at different depths.

Read Article
 
.: Upcoming Webinars

 
Technical Advancements in Line-Field Confocal Optical Coherence Tomography for Improving the Management of Skin Cancer Technical Advancements in Line-Field Confocal Optical Coherence Tomography for Improving the Management of Skin Cancer
Tue, Feb 28, 2023 10:00 AM - 11:00 AM EST
Line-field confocal optical coherence tomography (LC-OCT) is an imaging technique based on a combination of reflectance confocal microscopy and time-domain OCT. It can generate cellular-resolution vertical images, horizontal cross-sectional images, and three-dimensional (3D) images, yielding the possibility for optical biopsies of skin tissue in vivo and in real time. Jonas Ogien, Ph.D., of DAMAE Medical introduces the basic principles of LC-OCT and shares an overview of new technical advancements based on the technique.
 Register Now 



.: Next Issue:

 
Features
Photoacoustic Microscopy, Raman Spectroscopy, Dynamic Light Scattering & Alzheimer’s, Aptamer Molecular Photonic Beacons

Photonics Media is currently seeking technical feature articles on a variety of topics for publication in our magazine BioPhotonics. Please submit an informal 100-word abstract to Senior Editor Doug Farmer at [email protected], or use our online submission form www.photonics.com/submitfeature.aspx.

 

About BioPhotonics

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