OCT Presents Multidimensional Imaging for Diagnosis and Detection
Optical coherence tomography is a noninvasive imaging technique that is used to deliver high-resolution images in two or three dimensions. It relies on the wave-like properties of light to produce a low-coherence interference spectrum. In recent decades, this approach has proved to be very beneficial in industry and in medicine. In 1992, a startup company called Advanced Ophthalmic Devices, which grew out of a collaboration at MIT, first used an OCT system as a medical imaging technique for ophthalmology. Since that time, the technology has expanded to enable better understanding and detection of ophthalmic conditions and diseases, including glaucoma, cataracts, diabetic retinopathy, pigment cell detachment, and retinal detachment.
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Charge Clusters in a Monomeric Protein Alter Optical Absorption
Electronic absorption of proteins that lack cofactors, prosthetic groups, or noncoded amino acids as part of their structure has traditionally been thought to originate from protein backbone (peptide bond) and aromatic chromophores in the side chains. These side chains are chemical groups attached to the backbone that help the proteins to function. Among the protein chromophores — peptide bond/Trp/Tyr/Phe — the absorption occurs in the 190- to 320-nm region. Wavelengths above 320 nm are believed to be optically silent for such proteins.
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Fluorescence Microscopy Technique Images Brain at High Resolution
A noninvasive brain imaging technique developed by researchers at ETH Zurich and the University of Zurich works in the near-infrared (NIR) spectrum to enable superresolution deep-tissue fluorescence microscopy at four times the depth limit imposed by light diffusion. The technique, diffuse optical localization imaging (DOLI), operates in a resolution-depth regime previously inaccessible with optical methods.
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