Monthly newsletter focusing on how light-based technologies are being used in the life sciences.
Monthly newsletter focusing on how light-based technologies are being used in the life sciences. Includes news, features and product developments in lasers, imaging, optics, spectroscopy, microscopy, lighting and more. Manage your Photonics Media membership at BioPhotonics.com/subscribe.
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Fluorescence Lifetime Imaging Microscopy Provides Molecular Insights in Neurology
Fluorescence lifetime imaging microscopy (FLIM) is rapidly becoming a transformative tool in neurology, enabling the visualization of molecular and metabolic processes in living brain tissue and other samples with unprecedented detail. FLIM provides contrast based on the local biochemical environment, independent of fluorophore concentration or photobleaching, by measuring the excited-state lifetimes of intrinsic or extrinsic fluorophores.
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Functional Near-Infrared Spectroscopy Targets Changes in Brain Metabolism
Functional near-infrared spectroscopy was once confined to stationary, wired systems that limited studies to controlled laboratory environments. But today’s devices using this technology are lighter, wireless, and designed for true portability and clinical applicability. Ongoing research could change how the medical community views the utility of NIRS, expanding its use in neurodegenerative and neurodevelopmental disorders, rehabilitation, and psychiatry.
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Microscopy Connects Hypoxia in Brain to Stalled Blood Flow
Using high-resolution imaging with two-photon phosphorescent lifetime microscopy, researchers learned that even brief interruptions in blood flow to capillaries in the brain can cause rapid, localized drops in oxygen that probably extend into nearby brain tissue. These stalls in blood flow, in the smallest vessels in the brain, could play a role in brain diseases like stroke, Alzheimer’s disease, and traumatic brain injury, where such disruptions are common.
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