Definition of surface-enhanced Raman spectroscopy

Photonics Dictionary

surface-enhanced Raman spectroscopy: Surface-enhanced Raman spectroscopy (SERS) is an analytical technique that combines the principles of Raman spectroscopy with the enhancement provided by nanostructured metallic surfaces. Raman spectroscopy is a method used to study vibrational, rotational, and other low-frequency modes in a system by measuring the inelastic scattering of monochromatic light, typically from a laser source. SERS enhances the Raman signal by many orders of magnitude, enabling the detection and identification of trace amounts of molecules.

Key features and components of surface-enhanced Raman spectroscopy include:

Noble metal substrates: SERS relies on the interaction between molecules and noble metal surfaces, such as gold or silver. These metals support the excitation of localized surface plasmon resonances, leading to a significant enhancement of the Raman scattering signal.

Enhancement mechanisms: The enhancement in SERS arises from two main mechanisms: electromagnetic enhancement and chemical enhancement. The former is related to the excitation of localized surface plasmons, which intensify the incident electromagnetic field at the metal surface. The latter involves charge transfer between the metal and adsorbed molecules.

High sensitivity: SERS provides high sensitivity, allowing the detection of molecules at extremely low concentrations. This property makes it valuable in fields such as chemistry, biology, environmental science, and materials science.

Molecular fingerprints: Like traditional Raman spectroscopy, SERS provides molecular fingerprints based on the vibrational modes of chemical bonds. This enables the identification and characterization of various substances, even at low concentrations.

Biomedical applications: SERS has applications in biomedical research and diagnostics. It can be used for the detection of biomolecules, such as DNA, proteins, and drugs, and has potential applications in medical imaging and disease diagnosis.

Chemical imaging: SERS can be employed for chemical imaging, providing spatially resolved information about the distribution of different molecular species. This is particularly useful for studying heterogeneous samples.

Substrate design: The design and fabrication of nanostructured substrates play a crucial role in optimizing SERS performance. Substrates with specific nanostructures, such as nanoparticles or nanowires, enhance the electromagnetic field and facilitate the adsorption of molecules.

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