Imaging System Offers Clearer Tissue Visualization

Studying proteins and disease markers could get easier, thanks to a new high-throughput imaging system called Lamina.

A team at PerkinElmer Inc. designed the multilabel slide scanner to enable research pathologists to more easily analyze protein expression and the relationships between disease markers in formalin-fixed, paraffin-embedded (FFPE) tissue sections.

The device will provide a more comprehensive understanding of diseases for the development of more effective treatment and therapy, the researchers say.

A new high-throughput imaging system will make studying proteins and disease markers easier. Courtesy of PerkinElmer Inc.

This new system will offer improvements in real time during whole-slide scanning, which also enables clearer visualization of fluorescently labeled tissues. Users will be able to obtain more accurate information from histological specimens.

“The Lamina scanner can help research pathologists more effectively interpret their images by automating work flows and providing clearer and faster results,” said Jim Corbett, president of Diagnostics, Life Sciences & Technology at PerkinElmer. “These advanced digital pathology capabilities can help lead to a better understanding of disease.”

The system reduces interference from autofluorescence, an unwanted byproduct of tissue fixation, as well as fluorophore crosstalk, in which the signal from one fluorophore bleeds into multiple channels. Both of these effects obscure real signals, which can result in an incorrect assessment of a slide.

The scanner produces digital, whole-slide images of hematoxylin and eosin, immunohistochemistry, and immunofluorescence-labeled tissue sections and tissue microarrays.

For more information, visit www.perkinelmer.com.