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JULY 2007 | CONTENTS
Features
High-Content-Screen Microscopy Enables
Large-Scale Multiplex Image Analysis
by Jinhe Li and Min Hu, Abbott Laboratories
Technique provides reliable quantification in neuroscience drug discovery.
page 30
Flexible Image Analysis
by Dr. Thouis R. Jones and Dr. Anne E. Carpenter,
Broad Institute of Harvard and MIT
Open-source software automates high-throughput imaging.
page 31
Spotting Prostate Cancer Automatically 
by Hank Hogan, Contributing Editor
An algorithm classifies pathology samples as benign or
malignant.
page 33
Automation of Whole Slide and Tissue
Microarray Interpretation
by Dr. Sanford H. Barsky, Ohio State University College of
Medicine
and Bioimagene Inc.
A combination of algorithms is used to identify cancer.
page 34
Nanotechnology for Biology: Exploring
Cellular Activity and Abnormality
by Lauren I. Rugani, Contributing Editor
From in situ investigations to in vivo imaging, researchers
have embraced nanotechnology to help them understand the
intricacies of the human body at the smallest scale.
page 36
Medical Lasers
Medical Laser Market on the Rise
by Anne L. Fischer, Senior Editor
page 40
Compact High-Power Diode Lasers in 
Dental Surgery
by Dr. Frank Kubacki, Limo GmbH
A surgery workhorse gets smaller.
page 41
CO2 Laser Used in Minimally Invasive
Laryngeal Surgery
by Amy Beck and Hacki Hecht, Lumenis Inc.
A robotic micromanipulator is controlled by software to make
predefined incisions.
page 42
Holmium:YAG Laser in Clinical Urology
by Dr. Adam C. Mues and Dr. Bodo E. Knudsen,
Ohio State University Medical Center
Laser is used for treatment of bladder and prostate problems
and kidney stones.
page 44
ColumnsBiophotonics Research
page 48
Mapping the brain with light
Cells in eye not there just for looks
Hyperspectral imaging system helps surgeons identify key
anatomical structures
PDT with new photosensitizer kills drug-resistant bacteria
Indirect detection with MALDI
Cutting through the noise
Gold nanorods align to reveal cancer cells’ locations
Post Scripts
by Michael J. Lander
Nearly forgotten links to Alois Alzheimer
page 84
Departments
Editorial
page 8
Company Index
page 10
As We Go To Press
page 12
Technology Solutions 
page 14
Multimodal system contributes to advances in stem
cell therapy
Raman spectroscopy analyzes drug distribution for
potential
HIV prevention
Software aids monitoring of eye disease in diabetics
Biophotonics News
page 20
Minuscule bubbles may hold cancer-fighting power
Virtual patient model monitors organ movement in real time
NIST announces calibration tools for fluorescent instruments
CT divulges clues for forensic investigators
Nanoneedle built with carbon nanotubes
Dual-wave detection increases sensitivity of optical biosensors
From the Clinic
page 45
From the Journals
page 47
Courses & Shows
page 61
New to the Market
page 66
New Media
page 81
Advertiser Index
page 83
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